Barrel Pattern Formation Requires Serotonin Uptake by Thalamocortical Afferents, and Not Vesicular Monoamine Release
Persico A, Mengual E, Moessner R, Hall S, Revay R, Sora I, Arellano J, DeFelipe J, Giménez-Amaya J, Conciatori M, Marino R, Baldi A, Cabib S, Pascucci T, Uhl G, Murphy D, Lesch K, Keller F. Barrel Pattern Formation Requires Serotonin Uptake by Thalamocortical Afferents, and Not Vesicular Monoamine Release. Journal Of Neuroscience 2001, 21: 6862-6873. PMID: 11517274, PMCID: PMC6763105, DOI: 10.1523/jneurosci.21-17-06862.2001.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsBiogenic MonoaminesCarrier ProteinsExtracellular SpaceFenclonineGABA Plasma Membrane Transport ProteinsImmunohistochemistryMembrane GlycoproteinsMembrane ProteinsMembrane Transport ProteinsMiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsNeurons, AfferentNeuropeptidesOrganic Anion TransportersSerotoninSerotonin AntagonistsSerotonin Plasma Membrane Transport ProteinsSomatosensory CortexSynapsesSynaptic VesiclesThalamusVesicular Biogenic Amine Transport ProteinsVesicular Monoamine Transport ProteinsVibrissaeConceptsVMAT2-KO miceDensity of synapsesKnock-out (KO) miceVesicular monoamine transporterThalamocortical afferentsCerebral cortexSynaptic contactsThalamocortical neuronsKO miceLayer IVBarrel cortexMonoamine releaseNeonatal rodentsBarrel fieldPostnatal growthVesicular releaseSerotonin transporterMonoamine transportersCortexPlasma membrane serotonin transporterSynaptic vesiclesQuantitative electron microscopyMiceComplete absenceReleasePyramidal cell axons show a local specialization for GABA and 5‐HT inputs in monkey and human cerebral cortex
DeFelipe J, Arellano J, Gómez A, Azmitia E, Muñoz A. Pyramidal cell axons show a local specialization for GABA and 5‐HT inputs in monkey and human cerebral cortex. The Journal Of Comparative Neurology 2001, 433: 148-155. PMID: 11283956, DOI: 10.1002/cne.1132.Peer-Reviewed Original ResearchConceptsChandelier cell axon terminalsGamma-aminobutyric acidPyramidal cell axonsCerebral cortexPyramidal cellsAxon terminalsCell axonsHuman cerebral cortexDouble-labeling experimentsPowerful inhibitory mechanismChandelier cellsMonkey neocortexGABAergic interneuronsImmunoreactive fibersSerotonin receptorsSerotonin afferentsAxonal specializationsParacrine mannerLayers IISynaptic connectionsImmunocytochemical methodsProximal portionInhibitory mechanismClose appositionConfocal laser microscopy