Multi-modal immune phenotyping of maternal peripheral blood in normal human pregnancy
Apps R, Kotliarov Y, Cheung F, Han K, Chen J, Biancotto A, Babyak A, Zhou H, Shi R, Barnhart L, Osgood S, Belkaid Y, Holland S, Tsang J, Zerbe C. Multi-modal immune phenotyping of maternal peripheral blood in normal human pregnancy. JCI Insight 2020, 5 PMID: 32163376, PMCID: PMC7205264, DOI: 10.1172/jci.insight.134838.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBiomarkersFemaleGestational AgeHumansImmunophenotypingLeukocytesMiddle AgedPregnancyPregnancy Trimester, FirstConceptsMajor immune cell populationsImmune cell populationsGestational ageB cell subset frequenciesCell populationsFlow cytometryPeripheral immune phenotypeCell subset frequenciesNormal human pregnancyHigh-parameter flow cytometryComplete blood countMaternal peripheral bloodComplete blood count testT cell polarizationBlood count testMore persistent alterationsSerum proteomic analysisResource-limited settingsClinical flow cytometryParameter flow cytometrySomaLogic platformImmunological changesImmune phenotypingNormal pregnancyHuman pregnancy