2024
Acute and persistent responses after H5N1 vaccination in humans
Apps R, Biancotto A, Candia J, Kotliarov Y, Perl S, Cheung F, Farmer R, Mulè M, Rachmaninoff N, Chen J, Martins A, Shi R, Zhou H, Bansal N, Schum P, Olnes M, Milanez-Almeida P, Han K, Sellers B, Cortese M, Hagan T, Rouphael N, Pulendran B, King L, Manischewitz J, Khurana S, Golding H, van der Most R, Dickler H, Germain R, Schwartzberg P, Tsang J. Acute and persistent responses after H5N1 vaccination in humans. Cell Reports 2024, 43: 114706. PMID: 39235945, DOI: 10.1016/j.celrep.2024.114706.Peer-Reviewed Original ResearchH5N1 influenza vaccineImpact vaccine responsesTime pointsAdjuvant AS03H5N1 vaccineInfluenza vaccineT cellsVaccine responseVaccinated cohortHigh antibody respondersImmune stateVaccine antigensMultiple time pointsSingle-cell profilingInitial vaccinationSystems immunologyVaccinePersistent responseSurface proteinsCell type-specific signaturesChromatin accessibilityTranscription factorsH5N1DaysAS03
2018
AS03-adjuvanted H5N1 vaccine promotes antibody diversity and affinity maturation, NAI titers, cross-clade H5N1 neutralization, but not H1N1 cross-subtype neutralization
Khurana S, Coyle E, Manischewitz J, King L, Gao J, Germain R, Schwartzberg P, Tsang J, Golding H. AS03-adjuvanted H5N1 vaccine promotes antibody diversity and affinity maturation, NAI titers, cross-clade H5N1 neutralization, but not H1N1 cross-subtype neutralization. Npj Vaccines 2018, 3: 40. PMID: 30302282, PMCID: PMC6167326, DOI: 10.1038/s41541-018-0076-2.Peer-Reviewed Original ResearchAntibody responseWhole genome-fragment phage display librariesGenome-fragment phage display librariesNeuraminidase inhibition antibody titersVaccine-induced antibody responsesFragment phage display librariesHeterologous H5N1 strainsPolyclonal antibody responsePandemic influenza strainsAffinity maturationNAI titerUnadjuvanted vaccineAntibody titersNeutralization titersSeasonal strainsVaccine platformImmune responseInfluenza strainsAS03Antibody affinity maturationFuture vaccinesImmune memoryViral hemagglutininEpitope diversityVaccine