2024
Women with endometriosis in the United States: National Survey of Family Growth, 2011–2019
Al-Lami R, Taha S, Jalloul R, Taylor H. Women with endometriosis in the United States: National Survey of Family Growth, 2011–2019. Journal Of Endometriosis And Uterine Disorders 2024, 8: 100081. DOI: 10.1016/j.jeud.2024.100081.Peer-Reviewed Original ResearchNational Survey of Family GrowthAssociated with infertilityFamily GrowthRates of functional impairmentQuality of lifeNational surveyWeighted prevalencePrevalence of infertilityPain associated with endometriosisLongitudinal population-based studyAssociated with endometriosisPrevalence of endometriosisFunctional impairmentNationally representative samplePopulation-based studyDiminished quality of lifeLogistic regression analysisSample of womenCross-sectional studyCharacteristics of womenInfertile womenEndometriosisReproductive factorsU.S. womenAnalytic sampleTET3-overexpressing macrophages promote endometriosis
Lv H, Liu B, Dai Y, Li F, Bellone S, Zhou Y, Mamillapalli R, Zhao D, Venkatachalapathy M, Hu Y, Carmichael G, Li D, Taylor H, Huang Y. TET3-overexpressing macrophages promote endometriosis. Journal Of Clinical Investigation 2024, 134: e181839. PMID: 39141428, PMCID: PMC11527447, DOI: 10.1172/jci181839.Peer-Reviewed Original ResearchDisease-associated macrophagesTET3 overexpressionHuman endometriosis lesionsPathophysiology of endometriosisPro-inflammatory cytokine productionChronic inflammatory diseaseReproductive age womenEndometriosis lesionsE3 ubiquitin ligasePathogenic macrophagesCytokine productionEndometriosisInflammatory diseasesTET3 knockdownEndometriosis progressionPathogenic contributorsLet-7 miRNA expressionAge womenMacrophagesMouse macrophagesTherapeutic targetUbiquitin ligaseTET3MiceDiseaseProgesterone Receptor Status predicts Aggressiveness of Human Endometriotic lesions in Murine Avatars
Flores V, Sahin C, Taylor H. Progesterone Receptor Status predicts Aggressiveness of Human Endometriotic lesions in Murine Avatars. F&S Science 2024 PMID: 39393571, DOI: 10.1016/j.xfss.2024.10.004.Peer-Reviewed Original ResearchProgestin-based therapyAggressive forms of endometriosisPR lesionsProgesterone receptorGnRH antagonistMedroxyprogesterone acetatePR statusEndometriotic lesionsAggressive formResponse to MPAResponse to medical therapyPost-treatment sizeProgesterone receptor statusHuman endometriotic lesionsResponse to progestinsChronic gynecological diseaseDaily subcutaneous injectionsReproductive-age womenMouse xenograft modelResponse to medicationEndometrioma lesionsReceptor statusHormone suppressionPR expressionClinical responseA NOVEL CHIMERIC IMMUNOCONJUGATE MOLECULE (ICON3) SUPPRESSES ENDOMETRIOSIS IN A MURINE MODEL
Garg A, Mamillapalli R, Krikun G, Habata S, Atwani R, Taylor H. A NOVEL CHIMERIC IMMUNOCONJUGATE MOLECULE (ICON3) SUPPRESSES ENDOMETRIOSIS IN A MURINE MODEL. Fertility And Sterility 2024, 122: e337-e338. DOI: 10.1016/j.fertnstert.2024.08.065.Peer-Reviewed Original ResearchTHERAPEUTIC EFFECT OF ENDOMETRIOSIS ASSOCIATED MICRO-RNAS ON HUMAN ENDOMETRIOSIS XENOTRANSPLANTS
Gawde N, Mamillapalli R, Taylor H. THERAPEUTIC EFFECT OF ENDOMETRIOSIS ASSOCIATED MICRO-RNAS ON HUMAN ENDOMETRIOSIS XENOTRANSPLANTS. Fertility And Sterility 2024, 122: e156-e157. DOI: 10.1016/j.fertnstert.2024.07.556.Peer-Reviewed Original ResearchTHE USE OF AMD3100 FOR BONE MARROW DERIVED MESENCHYMAL STEM CELLS MOBILIZATION IN THE TREATMENT OF ASHERMAN’S SYNDROME
Flores V, Delis P, Mamillapalli R, Taylor H. THE USE OF AMD3100 FOR BONE MARROW DERIVED MESENCHYMAL STEM CELLS MOBILIZATION IN THE TREATMENT OF ASHERMAN’S SYNDROME. Fertility And Sterility 2024, 122: e36-e37. DOI: 10.1016/j.fertnstert.2024.07.168.Peer-Reviewed Original ResearchIL-6 PREVENTS EXCESSIVE INVASION IN ENDOMETRIOSIS
Mamillapalli R, Han E, Cevik E, Gawde N, Thomas K, Taylor H. IL-6 PREVENTS EXCESSIVE INVASION IN ENDOMETRIOSIS. Fertility And Sterility 2024, 122: e157-e158. DOI: 10.1016/j.fertnstert.2024.07.558.Peer-Reviewed Original ResearchENDOMETRIAL AND IMPLANTATION MODELING UTILIZING A HIGH-THROUGHPUT 3D SPHEROID GENERATION SYSTEM
Vélez-Avilés A, Abel A, Bergmann J, Cevik E, Zhong L, Taylor H, Sozen B. ENDOMETRIAL AND IMPLANTATION MODELING UTILIZING A HIGH-THROUGHPUT 3D SPHEROID GENERATION SYSTEM. Fertility And Sterility 2024, 122: e365. DOI: 10.1016/j.fertnstert.2024.08.130.Peer-Reviewed Original ResearchIs There an Association Between Endometriosis, Early Menopause, and Cardiovascular Disease?
Younis J, Taylor H. Is There an Association Between Endometriosis, Early Menopause, and Cardiovascular Disease? The Journal Of Clinical Endocrinology & Metabolism 2024, 109: e1946-e1949. PMID: 39083665, DOI: 10.1210/clinem/dgae508.Peer-Reviewed Original ResearchEarly menopauseEndometriotic cystectomyNatural menopauseCardiovascular riskCardiovascular diseaseEndometriosis-associated pelvic painIncreased risk of cardiovascular diseaseLaparoscopically diagnosed endometriosisRisk of cardiovascular diseaseEarly natural menopauseLarge-scale cohort studyPelvic painOvarian reserveBilateral casesMenopause onsetMultiple surgeriesEndometriosisCohort studyHazard ratioIncreased riskMenopauseCystectomyRisk factorsEstimates of associationConfounding factorsMedical Management of Endometriosis in Adolescent and Young Adult Women: A Review of 91 Cases of Biopsy-Confirmed Endometriosis
Li H, Esencan E, Song Y, Taylor H, Cho Y, Vash-Margita A. Medical Management of Endometriosis in Adolescent and Young Adult Women: A Review of 91 Cases of Biopsy-Confirmed Endometriosis. Journal Of Obstetrics And Gynaecology Canada 2024, 46: 102562. PMID: 38759792, DOI: 10.1016/j.jogc.2024.102562.Peer-Reviewed Original ResearchCombined oral contraceptivesBiopsy-proven endometriosisLNG-IUDManagement of endometriosisOral progestinInitial treatmentRetrospective chart review of womenChart review of womenMedical management of endometriosisProgestin-only formulationsLevonorgestrel intrauterine deviceReview of womenRetrospective chart reviewYoung adult patientsTertiary hospital systemPelvic painIntrauterine deviceOral contraceptivesTreatment regimensYounger patientsAdult patientsHormonal managementEndometriosisTreatment planningCurrent treatmentThe impact of ovarian endometrioma and endometriotic cystectomy on anti-Müllerian hormone, and antral follicle count: a contemporary critical appraisal of systematic reviews
Younis J, Taylor H. The impact of ovarian endometrioma and endometriotic cystectomy on anti-Müllerian hormone, and antral follicle count: a contemporary critical appraisal of systematic reviews. Frontiers In Endocrinology 2024, 15: 1397279. PMID: 38800489, PMCID: PMC11116636, DOI: 10.3389/fendo.2024.1397279.Peer-Reviewed Original ResearchAntral follicle countModerate to high-quality evidenceEndometriotic cystectomyOvarian reserveOvarian reserve measuresAnti-Mullerian hormoneLevel of evidenceOvarian endometriomaHigh-quality evidenceFollicle countImpact of ovarian endometriomasReproductive ageSystematic reviewEndometrioma per seImpact of endometriomaReserve measurementsSerum anti-Mullerian hormoneMonths post-surgeryBiomarker of choiceMeta-analysesEndometrioma diameterOvarian cystectomyComprehensive scoring systemBilateral casesUnilateral casesBone marrow mesenchymal stem cell-derived exosomes shuttle microRNAs to endometrial stromal fibroblasts that promote tissue proliferation /regeneration/ and inhibit differentiation
Bonavina G, Mamillapalli R, Krikun G, Zhou Y, Gawde N, Taylor H. Bone marrow mesenchymal stem cell-derived exosomes shuttle microRNAs to endometrial stromal fibroblasts that promote tissue proliferation /regeneration/ and inhibit differentiation. Stem Cell Research & Therapy 2024, 15: 129. PMID: 38693588, PMCID: PMC11064399, DOI: 10.1186/s13287-024-03716-1.Peer-Reviewed Original ResearchConceptsMiR-100-5pMiR-100MiR-21Transmission electron microscopyMiR-143MiR-143-3pMiR-21-5pEndometrial stromal fibroblastsStromal fibroblastsMicroRNAsExtracellular vesiclesElectron microscopyCell-free regenerative therapyNanoparticle tracking analysisMiRNAsBone marrow mesenchymal stem cell-derived exosomesBone marrow-derived stem cellsMesenchymal stem cell-derived exosomesStem cell-derived exosomesDelivery of microRNAsMarrow-derived stem cellsAssociated with several signaling pathwaysMediators of tissue repairMethodsExtracellular vesiclesUnpaired t-testLinzagolix therapy versus a placebo in patients with endometriosis-associated pain: a prospective, randomized, double-blind, Phase 3 study (EDELWEISS 3)
Donnez J, Becker C, Taylor H, Herrera F, Donnez O, Horne A, Paszkowski M, Petraglia F, Renner S, Patel A, Boolell M, Bestel E, Dolmans M. Linzagolix therapy versus a placebo in patients with endometriosis-associated pain: a prospective, randomized, double-blind, Phase 3 study (EDELWEISS 3). Human Reproduction 2024, 39: 1208-1221. PMID: 38648863, PMCID: PMC11144970, DOI: 10.1093/humrep/deae076.Peer-Reviewed Original ResearchNon-menstrual pelvic painAdd-back therapyEndometriosis-associated painPelvic painMonths of therapyPhase 3 studyGedeon RichterData monitoring boardDaily doseStatistically significant reductionPlacebo groupDouble-blindRoche DiagnosticsTreatment of endometriosis-associated painHormonal add-back therapyRates of hot flushesReduce dysmenorrheaGonadotropin-releasing hormone antagonistRisk of bone lossDATE OF FIRST PATIENT’S ENROLMENT:Overall pelvic painPublished phase 2Hypoestrogenic side effectsMonitoring boardCompared to placeboAuthors’ Reply
Group T, Canis M, Abbott J, Abrao M, Al-Jefout M, Bedaiwy M, Benagiano G, Burns K, Carmona F, Chapron C, Critchley H, de Ziegler D, Falcone T, Fazleabas A, Ferrero S, Garcia-Velasco J, Gargett C, Greaves E, Griffith L, Habiba M, Harada T, Hull M, Kaufman Y, Issacson K, Khan K, Kim M, Koninckx P, Lessey B, Martin D, Matsuzaki S, Mishra G, Osuga Y, Petraglia F, Popov A, Roman H, Romano A, Seckin T, Saounders P, Somigliana E, Guo S, Taylor H, Vercellini P, Vigano P, Johnson N. Authors’ Reply. Journal Of Minimally Invasive Gynecology 2024, 31: 624-626. PMID: 38641049, DOI: 10.1016/j.jmig.2024.04.008.Peer-Reviewed Original ResearchHeterozygous ZNHIT3 variants within the 17q12 recurrent deletion region are associated with Mayer-Rokitansky-Kuster Hauser (MRKH) syndrome
Brakta S, Du Q, Chorich L, Hawkins Z, Sullivan M, Ko E, Kim H, Knight J, Taylor H, Friez M, Phillips J, Layman L. Heterozygous ZNHIT3 variants within the 17q12 recurrent deletion region are associated with Mayer-Rokitansky-Kuster Hauser (MRKH) syndrome. Molecular And Cellular Endocrinology 2024, 589: 112237. PMID: 38599276, DOI: 10.1016/j.mce.2024.112237.Peer-Reviewed Original ResearchCNV regionsDetect intragenic deletionsSingle nucleotide variantsRecurrent deletion regionsC-terminal regionSequencing of familiesGenome sequenceNucleotide variantsProtein expression in vitroLXXLL sequenceMissense variantsDeleted regionChromosome 17q12Exome sequencingGenetic approachesIntragenic deletionsTruncating variantsSanger sequencingSplice variantsMolecular basisHeterozygous variantsStopgain variantsZNHIT3Steroid hormone bindingExpression in vitroHigh NaCl Concentrations in Water Are Associated with Developmental Abnormalities and Altered Gene Expression in Zebrafish
Seli D, Prendergast A, Ergun Y, Tyagi A, Taylor H. High NaCl Concentrations in Water Are Associated with Developmental Abnormalities and Altered Gene Expression in Zebrafish. International Journal Of Molecular Sciences 2024, 25: 4104. PMID: 38612913, PMCID: PMC11012806, DOI: 10.3390/ijms25074104.Peer-Reviewed Original ResearchConceptsNaCl concentrationGene expressionIncreasing NaCl concentrationATM signaling pathwayUninflated swim bladderSwim bladder developmentHigh NaCl concentrationsEmbryo growthAssociated with developmental abnormalitiesSwim bladderLarval stageEarly embryo growthEmbryonic deathDevelopmental abnormalitiesSignaling pathwayDevelopment of zebrafishGenes SHHCalcium chlorideGenesSodium chlorideE3 mediumStages of developmentZebrafish embryosAffected ecosystemsPotassium chlorideRing Chromosome 12
Taylor H, Wen J. Ring Chromosome 12. 2024, 191-199. DOI: 10.1007/978-3-031-47530-6_16.Peer-Reviewed Original ResearchVilaprisan for the treatment of symptomatic endometriosis: results from a terminated phase 2b randomized controlled trial
Taylor H, Dong L, Haikonen J, Oppelt P, Tamussino K, Wenzl R, Faustmann T, Groettrup-Wolfers E, Ren X, Seitz C. Vilaprisan for the treatment of symptomatic endometriosis: results from a terminated phase 2b randomized controlled trial. F&S Reports 2024, 5: 189-196. PMID: 38983729, PMCID: PMC11228778, DOI: 10.1016/j.xfre.2024.03.002.Peer-Reviewed Original ResearchPelvic painSymptomatic endometriosisTreatment of symptomatic endometriosisEndometriosis-associated pelvic painBaseline to month 3Use of pain medicationAverage pain scoreMonths of treatmentPhase 2b randomized controlled trialAssess treatment effectsOutcome measures Primary outcomesPlacebo recipientsRandomized controlled trialsPain scoresMonth 3Pain medicationIncreased painVilaprisanPlaceboPrimary outcomeEndometriosisToxicity findingsIntervention participantsClinical relevanceBleeding intensityUterine fibroid–related infertility: mechanisms and management
Donnez J, Taylor H, Marcellin L, Dolmans M. Uterine fibroid–related infertility: mechanisms and management. Fertility And Sterility 2024, 122: 31-39. PMID: 38453041, DOI: 10.1016/j.fertnstert.2024.02.049.Peer-Reviewed Original ResearchUterine artery embolizationUterine fibroidsAssociation of fibroidsAdd-back therapyHeavy menstrual bleedingBaseline to weekOral GnRH antagonistPresence of fibroidsNon-surgical approachFocused ultrasoundFibroid volumeMyoma volumeArtery embolizationMenstrual bleedingCurrent management strategiesGnRH antagonistEchographic guidanceSurgical interventionFibroidsInfertilityMedical treatmentUterineWomenOptimal dosageSource of controversyA Call for New Theories on the Pathogenesis and Pathophysiology of Endometriosis
Canis M, Abbott J, Abrao M, Al-Jefout M, Bedaiwy M, Benagiano G, Burns K, Canis M, Carmona F, Chapron C, Critchley H, de Ziegler D, Falcone T, Fazleabas A, Ferrero S, Garcia-Velasco J, Gargett C, Greaves E, Griffith L, Guo S, Habiba M, Harada T, Hull M, Johnson N, Kaufman Y, Issacson K, Khan K, Kim M, Koninckx P, Lessey B, Martin D, Matsuzaki S, Mishra G, Osuga Y, Petraglia F, Popov A, Roman H, Romano A, Saunders P, Seckin T, Somigliana E, Taylor H, Taylor R, Vercellini P, Vigano P. A Call for New Theories on the Pathogenesis and Pathophysiology of Endometriosis. Journal Of Minimally Invasive Gynecology 2024, 31: 371-377. PMID: 38365066, DOI: 10.1016/j.jmig.2024.02.004.Peer-Reviewed Original Research