2021
Intracerebral Hemorrhage in Patients With COVID-19
Leasure AC, Khan YM, Iyer R, Elkind MSV, Sansing LH, Falcone GJ, Sheth KN. Intracerebral Hemorrhage in Patients With COVID-19. Stroke 2021, 52: e321-e323. PMID: 34082576, PMCID: PMC8238884, DOI: 10.1161/strokeaha.121.034215.Peer-Reviewed Original ResearchAdolescentAdultAge FactorsAgedAnticoagulantsCerebral HemorrhageCOVID-19C-Reactive ProteinExtracorporeal Membrane OxygenationFemaleHeart Disease Risk FactorsHospital MortalityHospitalizationHumansIntensive Care UnitsInterleukin-6MaleMiddle AgedRegistriesRespiration, ArtificialRisk FactorsSARS-CoV-2Sex FactorsUnited StatesYoung AdultAndexanet Alfa Versus 4-Factor Prothrombin Complex Concentrate for Reversal of Factor Xa Inhibitors in Intracranial Hemorrhage
Ammar AA, Ammar MA, Owusu KA, Brown SC, Kaddouh F, Elsamadicy AA, Acosta JN, Falcone GJ. Andexanet Alfa Versus 4-Factor Prothrombin Complex Concentrate for Reversal of Factor Xa Inhibitors in Intracranial Hemorrhage. Neurocritical Care 2021, 35: 255-261. PMID: 33403588, PMCID: PMC10273779, DOI: 10.1007/s12028-020-01161-5.Peer-Reviewed Original ResearchConceptsFactor Xa inhibitorsSpontaneous intracranial hemorrhageSpontaneous intraparenchymal hemorrhageAndexanet alfaIntracranial hemorrhageProthrombin complex concentrateThrombotic eventsIntraparenchymal hemorrhageFunctional outcomeComplex concentrateXa inhibitorsFour-factor prothrombin complex concentrateOnset of ICHConsecutive adult patientsGood functional outcomeModified Rankin scoreSubgroup of patientsNumber of patientsThromboembolic eventsRankin scoreAdult patientsMedian ageRetrospective reviewHematoma volumeResultsA total
2020
Combining Imaging and Genetics to Predict Recurrence of Anticoagulation-Associated Intracerebral Hemorrhage
Biffi A, Urday S, Kubiszewski P, Gilkerson L, Sekar P, Rodriguez-Torres A, Bettin M, Charidimou A, Pasi M, Kourkoulis C, Schwab K, DiPucchio Z, Behymer T, Osborne J, Morgan M, Moomaw CJ, James ML, Greenberg SM, Viswanathan A, Gurol ME, Worrall BB, Testai FD, McCauley JL, Falcone GJ, Langefeld CD, Anderson CD, Kamel H, Woo D, Sheth KN, Rosand J. Combining Imaging and Genetics to Predict Recurrence of Anticoagulation-Associated Intracerebral Hemorrhage. Stroke 2020, 51: 2153-2160. PMID: 32517581, PMCID: PMC7311289, DOI: 10.1161/strokeaha.120.028310.Peer-Reviewed Original ResearchConceptsCortical superficial siderosisICH recurrenceCerebral microbleedsSuperficial siderosisIntracerebral hemorrhageRecurrent ICHMRI markersOral anticoagulation therapyPotent risk factorRecurrent hemorrhagic strokeLongitudinal cohort studyLow-risk categoryLow-risk individualsΕ2/ε4ICH survivorsAnticoagulation therapyCohort studyHemorrhagic strokeProspective studyRecurrence rateΕ4 variantRisk factorsClinical impactERICH studyΕ4 alleleAnticoagulation after intracerebral hemorrhage: a perfect clinical scenario for genetics-based precision medicine
Brown SC, Sheth KN, Falcone GJ. Anticoagulation after intracerebral hemorrhage: a perfect clinical scenario for genetics-based precision medicine. Pharmacogenomics 2020, 21: 307-309. PMID: 32238090, DOI: 10.2217/pgs-2019-0181.Peer-Reviewed Original Research
2018
Cardioembolic Stroke Risk and Recovery After Anticoagulation-Related Intracerebral Hemorrhage
Murphy MP, Kuramatsu JB, Leasure A, Falcone GJ, Kamel H, Sansing LH, Kourkoulis C, Schwab K, Elm JJ, Gurol ME, Tran H, Greenberg SM, Viswanathan A, Anderson CD, Schwab S, Rosand J, Shi FD, Kittner SJ, Testai FD, Woo D, Langefeld CD, James ML, Koch S, Huttner HB, Biffi A, Sheth KN. Cardioembolic Stroke Risk and Recovery After Anticoagulation-Related Intracerebral Hemorrhage. Stroke 2018, 49: 2652-2658. PMID: 30355194, PMCID: PMC6211810, DOI: 10.1161/strokeaha.118.021799.Peer-Reviewed Original ResearchConceptsCardioembolic stroke riskOral anticoagulation therapyRankin Scale scoreIntracerebral hemorrhageFunctional recoveryStroke riskAnticoagulation resumptionVASc scoreRecurrent strokeAnticoagulation therapyScale scoreAnticoagulation-related intracerebral hemorrhageDecreased likelihoodSurvivors of ICHModified Rankin Scale scoreNonvalvular atrial fibrillationRecurrent intracerebral hemorrhageOral anticoagulation treatmentICH survivorsTherapy resumptionAnticoagulation treatmentCardioembolic strokeIschemic strokeAtrial fibrillationIndex event
2014
Risk Factors for Computed Tomography Angiography Spot Sign in Deep and Lobar Intracerebral Hemorrhage Are Shared
Radmanesh F, Falcone GJ, Anderson CD, Battey TW, Ayres AM, Vashkevich A, McNamara KA, Schwab K, Romero JM, Viswanathan A, Greenberg SM, Goldstein JN, Rosand J, Brouwers HB. Risk Factors for Computed Tomography Angiography Spot Sign in Deep and Lobar Intracerebral Hemorrhage Are Shared. Stroke 2014, 45: 1833-1835. PMID: 24876264, PMCID: PMC4116606, DOI: 10.1161/strokeaha.114.005276.Peer-Reviewed Original ResearchMeSH KeywordsAnticoagulantsCerebral AngiographyCerebral HemorrhageFemaleHumansMaleRisk FactorsTomography, X-Ray ComputedWarfarinConceptsLobar intracerebral hemorrhageComputed tomography angiographyBaseline ICH volumeIntracerebral hemorrhagePrimary intracerebral hemorrhageSpot signTomography angiographyICH locationICH volumeMultivariable regressionChronic cerebral small vessel diseaseCerebral small vessel diseaseDeep intracerebral hemorrhageSmall vessel diseaseTomography angiography spot signLobar ICH patientsComputed tomography angiography spot signAvailable computed tomography angiographySpot sign presenceSymptom onsetICH patientsPoor outcomeVessel diseaseAcute manifestationsHematoma expansion
2013
Warfarin and Statins are Associated with Hematoma Volume in Primary Infratentorial Intracerebral Hemorrhage
Falcone GJ, Brouwers HB, Biffi A, Anderson CD, Battey TW, Ayres AM, Vashkevich A, Schwab KM, Rost NS, Goldstein JN, Viswanathan A, Greenberg SM, Rosand J. Warfarin and Statins are Associated with Hematoma Volume in Primary Infratentorial Intracerebral Hemorrhage. Neurocritical Care 2013, 21: 192-199. PMID: 23839705, PMCID: PMC4107188, DOI: 10.1007/s12028-013-9839-9.Peer-Reviewed Original ResearchConceptsInfratentorial intracerebral hemorrhageIntracerebral hemorrhageICH volumeSurgical evacuationHematoma volumeBrainstem ICHSingle-center studySupratentorial intracerebral hemorrhageWarfarin treatmentStatin treatmentEmergency departmentICH casesRetrospective analysisCT scanLogistic regressionWarfarinICH subjectsLimited dataHemorrhageStatinsFurther studiesComputer-assisted methodTreatmentInverse relationLinear regression