George Aghajanian, MD
Professor Emeritus of PsychiatryCards
About
Research
Publications
2009
Modeling “psychosis” in vitro by inducing disordered neuronal network activity in cortical brain slices
Aghajanian GK. Modeling “psychosis” in vitro by inducing disordered neuronal network activity in cortical brain slices. Psychopharmacology 2009, 206: 575-585. PMID: 19241062, PMCID: PMC2755104, DOI: 10.1007/s00213-009-1484-9.Peer-Reviewed Original ResearchConceptsAberrant network activityBrain slicesReceptor agonistPyramidal cellsLayer V pyramidal cellsRecent phase II clinical trialPhase II clinical trialGABAA receptor antagonismStandard antipsychotic drugsMGlu2/3 receptor agonistGlutamatergic pyramidal cellsNetwork activityCortical brain slicesDopamine receptor agonistsTreatment of schizophreniaUsual side effectsPrefrontal brain slicesNeuronal network activityInterneuron deficitsGABA interneuronsClinical efficacyLysergic acid diethylamideMetabotropic receptorsReceptor antagonismClinical endpoints
2008
Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: Role of corticosterone-mediated apical dendritic atrophy
Liu RJ, Aghajanian GK. Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: Role of corticosterone-mediated apical dendritic atrophy. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 359-364. PMID: 18172209, PMCID: PMC2224217, DOI: 10.1073/pnas.0706679105.Peer-Reviewed Original ResearchConceptsExcitatory postsynaptic currentsLayer V pyramidal neuronsMedial prefrontal cortexApical dendritic atrophyDendritic atrophyPyramidal neuronsRestraint stressPrefrontal cortexGlucocorticoid receptor antagonist RU486Apical dendritic fieldReceptor antagonist RU486Mild restraint stressWhole-cell recordingsMPFC slicesChronic treatmentStress-induced reductionExcitatory responsesSpine densityApical dendritesPostsynaptic currentsDendritic fieldsExcitatory inputsPyramidal cellsAntagonist RU486Selective atrophy
1972
SYNAPTOSOMES FROM FOREBRAINS OF RATS WITH MIDBRAIN RAPHE LESIONS: SELECTIVE REDUCTION OF SEROTONIN UPTAKE
KUHAR M, ROTH R, AGHAJANIAN G. SYNAPTOSOMES FROM FOREBRAINS OF RATS WITH MIDBRAIN RAPHE LESIONS: SELECTIVE REDUCTION OF SEROTONIN UPTAKE. Journal Of Pharmacology And Experimental Therapeutics 1972, 181: 36-45. PMID: 4552069, DOI: 10.1016/s0022-3565(25)29173-x.Peer-Reviewed Original ResearchConceptsConcentrations of 5-HTRaphe lesionsSynaptosomal uptakeUptake of 3H-5-HTTricyclic agent imipramineMidbrain raphe lesionsNerve endingsMidbrain raphe nucleiTryptophan hydroxylase activityTime coursePlacement of lesionsRaphe nucleusSerotonin uptakeRaphe neuronsLesioned animalsUptake activityMidbrain areaL-norepinephrineLesionsHydroxylase activityRapheIncubation mediumForebrainL-tryptophanAnimals
1968
STIMULATION OF THE MIDBRAIN RAPHE: EFFECT ON SEROTONIN METABOLISM
SHEAUD M, AGHAJANIAN G. STIMULATION OF THE MIDBRAIN RAPHE: EFFECT ON SEROTONIN METABOLISM. Journal Of Pharmacology And Experimental Therapeutics 1968, 163: 425-430. PMID: 4878661, DOI: 10.1016/s0022-3565(25)28089-2.Peer-Reviewed Original Research
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