2015
Nlrp6 regulates intestinal antiviral innate immunity
Wang P, Zhu S, Yang L, Cui S, Pan W, Jackson R, Zheng Y, Rongvaux A, Sun Q, Yang G, Gao S, Lin R, You F, Flavell R, Fikrig E. Nlrp6 regulates intestinal antiviral innate immunity. Science 2015, 350: 826-830. PMID: 26494172, PMCID: PMC4927078, DOI: 10.1126/science.aab3145.Peer-Reviewed Original ResearchConceptsI/III interferonIntestinal antiviral innate immunityEncephalomyocarditis virusEnteric virus infectionType I/III interferonsGut microbiota homeostasisAntiviral innate immunityViral RNA sensorsViral loadControl miceVirus infectionGastrointestinal tractMicrobiota homeostasisSimilar mortalityIII interferonsAntibacterial immunityInnate immunityIntestinal tractRNA helicase DHX15MiceViral RNANLRP6Murine norovirus-1RNA sensorsMortality
2003
Immunoassay Targeting Nonstructural Protein 5 To Differentiate West Nile Virus Infection from Dengue and St. Louis Encephalitis Virus Infections and from Flavivirus Vaccination
Wong SJ, Boyle RH, Demarest VL, Woodmansee AN, Kramer LD, Li H, Drebot M, Koski RA, Fikrig E, Martin DA, Shi PY. Immunoassay Targeting Nonstructural Protein 5 To Differentiate West Nile Virus Infection from Dengue and St. Louis Encephalitis Virus Infections and from Flavivirus Vaccination. Journal Of Clinical Microbiology 2003, 41: 4217-4223. PMID: 12958248, PMCID: PMC193845, DOI: 10.1128/jcm.41.9.4217-4223.2003.Peer-Reviewed Original ResearchConceptsSt. Louis encephalitis virus infectionEncephalitis virus infectionWest Nile virusWNV infectionVirus infectionFlavivirus vaccinationWest Nile virus infectionNatural WNV infectionWNV structural proteinsDetection of antibodiesBlood transfusionRecent infectionOrgan transplantationSerologic assaysImmune responseDengue virusInfectionProtein 3Nonstructural protein 3Nile virusNatural transmissionProtein 5Structural proteinsLack specificityFrequent epidemics