2020
Short-Term Consumption of Sucralose with, but Not without, Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans
Dalenberg JR, Patel BP, Denis R, Veldhuizen MG, Nakamura Y, Vinke PC, Luquet S, Small DM. Short-Term Consumption of Sucralose with, but Not without, Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans. Cell Metabolism 2020, 31: 493-502.e7. PMID: 32130881, PMCID: PMC7784207, DOI: 10.1016/j.cmet.2020.01.014.Peer-Reviewed Original ResearchConceptsGlucose metabolismPrevalence of obesityType 2 diabetesSugar-sweetened beveragesConsumption of sucraloseHealthy human participantsInsulin sensitivityTerm consumptionTaste perceptionMetabolismLong-term decreaseSweet tasteMetabolic sensitivityComorbiditiesGeneral consensusObesityDiabetesHuman participantsBeveragesMidbrainPrevalenceBrainSimilar relationship
2018
Sweet taste potentiates the reinforcing effects of e-cigarettes
Kroemer NB, Veldhuizen MG, Delvy R, Patel BP, O'Malley SS, Small DM. Sweet taste potentiates the reinforcing effects of e-cigarettes. European Neuropsychopharmacology 2018, 28: 1089-1102. PMID: 30093174, DOI: 10.1016/j.euroneuro.2018.07.102.Peer-Reviewed Original Research
2017
Integration of Sweet Taste and Metabolism Determines Carbohydrate Reward
Veldhuizen MG, Babbs RK, Patel B, Fobbs W, Kroemer NB, Garcia E, Yeomans MR, Small DM. Integration of Sweet Taste and Metabolism Determines Carbohydrate Reward. Current Biology 2017, 27: 2476-2485.e6. PMID: 28803868, PMCID: PMC5745144, DOI: 10.1016/j.cub.2017.07.018.Peer-Reviewed Original ResearchConceptsCaloric loadGreater metabolic responseNon-linear associationMetabolic responseSugar-sweetened beveragesBrain responsesLow-calorie beveragesHigh-calorie beveragesNon-nutritive sweetenersGreater brain responsePost-ingestive signalsHuman studiesSweet tasteNutrient metabolismCarbohydrate metabolismNovel mechanismBeveragesPotencyAssociationMetabolismCarbohydrate rewards
2011
Amygdala response to sucrose consumption is inversely related to artificial sweetener use
Rudenga KJ, Small DM. Amygdala response to sucrose consumption is inversely related to artificial sweetener use. Appetite 2011, 58: 504-507. PMID: 22178008, PMCID: PMC3289048, DOI: 10.1016/j.appet.2011.12.001.Peer-Reviewed Original Research
2010
The Insular Taste Cortex Contributes to Odor Quality Coding
Veldhuizen MG, Nachtigal D, Teulings L, Gitelman DR, Small DM. The Insular Taste Cortex Contributes to Odor Quality Coding. Frontiers In Human Neuroscience 2010, 4: 58. PMID: 20700500, PMCID: PMC2917218, DOI: 10.3389/fnhum.2010.00058.Peer-Reviewed Original ResearchCommon central mechanismInsular taste cortexTaste cortexCentral mechanismsFood odorsNon-food odorsOdor quality codingOlfactory cortexInsular cortexOlfactory stimulationCortexCentral pathwaysCortex contributesSweet tasteGustatory systemOlfactory stimuliInsulaStimulationDiscrete mechanismsSensationTaste qualityQuality codingOdor sweetnessPiriformSweetness ratings