2024
Representation of Older Adults in the ACC/AHA/SCAI Guideline for Coronary Artery Revascularization
Jamil Y, Sibindi C, Park D, Frampton J, Damluji A, Nanna M. Representation of Older Adults in the ACC/AHA/SCAI Guideline for Coronary Artery Revascularization. JAMA Network Open 2024, 7: e2421547. PMID: 38995647, PMCID: PMC11245718, DOI: 10.1001/jamanetworkopen.2024.21547.Peer-Reviewed Original ResearchShorter Dual Antiplatelet Therapy for Older Adults After Percutaneous Coronary Intervention
Park D, Hu J, Jamil Y, Kelsey M, Jones W, Frampton J, Kochar A, Aronow W, Damluji A, Nanna M. Shorter Dual Antiplatelet Therapy for Older Adults After Percutaneous Coronary Intervention. JAMA Network Open 2024, 7: e244000. PMID: 38546647, PMCID: PMC10979312, DOI: 10.1001/jamanetworkopen.2024.4000.Peer-Reviewed Original ResearchConceptsOlder adultsMonths of DAPTDuration of dual antiplatelet therapySystematic reviewRandomized clinical trialsPercutaneous coronary interventionMeta-analysisPreferred Reporting ItemsAssess data qualityRisk of bleedingDuration of DAPTDual antiplatelet therapyWeb of ScienceMain OutcomesReporting ItemsData extractionAbstracted dataSecondary outcomesRisk ratioAntiplatelet therapyPrimary outcomeCochrane LibraryCoronary interventionReference groupNetwork meta-analysis
2023
Complex Percutaneous Coronary Intervention Outcomes in Older Adults
Hanna J, Wang S, Kochar A, Park D, Damluji A, Henry G, Ahmad Y, Curtis J, Nanna M. Complex Percutaneous Coronary Intervention Outcomes in Older Adults. Journal Of The American Heart Association 2023, 12: e029057. PMID: 37776222, PMCID: PMC10727245, DOI: 10.1161/jaha.122.029057.Peer-Reviewed Original ResearchConceptsNoncomplex percutaneous coronary interventionsComplex percutaneous coronary interventionStable ischemic heart diseasePercutaneous coronary interventionIschemic heart diseaseTarget lesion revascularizationEvent-free survivalHeart diseaseOlder adultsCause deathLesion revascularizationClinical characteristicsElective percutaneous coronary interventionPercutaneous coronary intervention outcomesWorse event-free survivalMedical therapy useCox regression modelLarge health systemNoncardiac comorbiditiesRevascularization riskCoronary interventionTherapy useClinical outcomesDisease featuresLower riskComparison of intravascular ultrasound, optical coherence tomography, and conventional angiography‐guided percutaneous coronary interventions: A systematic review, network meta‐analysis, and meta‐regression
Park D, An S, Jolly N, Attanasio S, Yadav N, Gutierrez J, Nanna M, Rao S, Vij A. Comparison of intravascular ultrasound, optical coherence tomography, and conventional angiography‐guided percutaneous coronary interventions: A systematic review, network meta‐analysis, and meta‐regression. Catheterization And Cardiovascular Interventions 2023, 102: 440-450. PMID: 37483068, PMCID: PMC10908343, DOI: 10.1002/ccd.30784.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsPercutaneous coronary interventionOptical coherence tomographyCoronary angiographyIntravascular ultrasoundCoronary interventionCardiac deathClinical outcomesClinical efficacyConventional angiography-guided PCIAngiography-guided percutaneous coronary interventionCoherence tomographyUse of IVUSSuperiority of OCTAdverse cardiovascular eventsRandomized clinical trialsConventional coronary angiographyImaging modalitiesComparative clinical efficacyBest imaging modalityIntracoronary imaging modalityLesion revascularizationPCI guidanceCardiovascular eventsCause mortalityDelirium in older adults after percutaneous coronary intervention: Prevalence, risks, and clinical phenotypes
Park D, Jamil Y, Hu J, Lowenstern A, Frampton J, Abdullah A, Damluji A, Ahmad Y, Soufer R, Nanna M. Delirium in older adults after percutaneous coronary intervention: Prevalence, risks, and clinical phenotypes. Cardiovascular Revascularization Medicine 2023, 57: 60-67. PMID: 37414611, PMCID: PMC10730763, DOI: 10.1016/j.carrev.2023.06.010.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionHospital mortalityHigher oddsOlder adultsHospital deliriumCoronary interventionAdverse health-related outcomesInpatient percutaneous coronary interventionNon-home dischargePeri-procedural settingAcute kidney injuryImpact of deliriumPost-procedural complicationsNational Inpatient SampleHealth-related outcomesDelirium preventionHospital complicationsMore comorbiditiesGastrointestinal hemorrhageKidney injuryAdverse eventsSecondary outcomesBlood transfusionPrimary outcomeIntracranial hemorrhageChronological comparison of TAVI and SAVR stratified to surgical risk: a systematic review, meta-analysis, and meta-regression
Park D, An S, Kassab K, Jolly N, Attanasio S, Sawaqed R, Malhotra S, Doukky R, Vij A. Chronological comparison of TAVI and SAVR stratified to surgical risk: a systematic review, meta-analysis, and meta-regression. Acta Cardiologica 2023, 78: 778-789. PMID: 37294002, DOI: 10.1080/00015385.2023.2218025.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementTranscatheter aortic valve implantationAll-cause mortalitySevere aortic regurgitationSevere paravalvular regurgitationSurgical riskAortic regurgitationPacemaker placementParavalvular regurgitationFollow-upAlternative to surgical aortic valve replacementAssociated with higher all-cause mortalityLong-term follow-upNewer-generation valvesRisk of all-cause mortalityPeriod of follow-upHigh surgical riskIntermediate surgical riskLow surgical riskMeta-regressionAortic valve replacementSevere aortic stenosisMeta-analysisLong-term outcomesScore-matched studyTrends in outcomes and racial disparities in adult hospitalizations for immune thrombocytopenia over a decade
Litvin R, Dasgupta M, Deenadayalan V, Cuartas-Mesa M, Olafimihan A, Park D, Zia M, Shaka H. Trends in outcomes and racial disparities in adult hospitalizations for immune thrombocytopenia over a decade. Annals Of Hematology 2023, 102: 1677-1686. PMID: 37147362, DOI: 10.1007/s00277-023-05249-8.Peer-Reviewed Original ResearchConceptsImmune thrombocytopeniaAutoimmune-mediated platelet destructionWhite patientsRate of intracranial hemorrhageITP managementRate of epistaxisLow platelet countRare hematologic disorderNationwide population-based studyTotal healthcare chargesDiagnosis of exclusionResponse to treatmentPopulation-based studyLength of stayNational Inpatient SampleThrombopoietin deficiencyPlatelet destructionIntracranial hemorrhagePlatelet countHematological disordersProspective studyDisease behaviorPatientsHispanic patientsHospital outcomesImpact of Hospital Readmissions Reduction Program Policy on 30-Day and 90-Day Readmissions in Patients With Acute Myocardial Infarction: A 10-Year Trend From the National Readmissions Database
Sana M, Kumi D, Park D, Asemota I, DeAngelo S, Yilmaz M, Hammo H, Shaka H, Vij A. Impact of Hospital Readmissions Reduction Program Policy on 30-Day and 90-Day Readmissions in Patients With Acute Myocardial Infarction: A 10-Year Trend From the National Readmissions Database. Current Problems In Cardiology 2023, 48: 101696. PMID: 36921652, DOI: 10.1016/j.cpcardiol.2023.101696.Peer-Reviewed Original ResearchConceptsHospital Readmissions Reduction ProgramAcute myocardial infarction hospitalizationsCenters for Medicare & Medicaid ServicesAcute myocardial infarctionSecondary analysisHealth care utilizationReadmissions Reduction ProgramCare utilizationNational Readmission DatabaseImpact of Hospital Readmissions Reduction ProgramMyocardial infarctionMedicare hospitalizationsLength of stayMedicaid ServicesAll-causeHospital readmissionReadmissions DatabaseReduction programsEconomic burdenPrimary analysisReadmissionHospitalDownward trendFactor Xa inhibitors versus vitamin K antagonist in morbidly obese patients with venous thromboembolism: a systematic review and meta-analysis
Park D, An S, Arif A, Sana M, Vij A. Factor Xa inhibitors versus vitamin K antagonist in morbidly obese patients with venous thromboembolism: a systematic review and meta-analysis. BMC Cardiovascular Disorders 2023, 23: 100. PMID: 36814196, PMCID: PMC9945392, DOI: 10.1186/s12872-023-03067-4.Peer-Reviewed Original ResearchConceptsClinically relevant non-major bleedingNon-vitamin K antagonist oral anticoagulantsVitamin K antagonistsMorbidly obese patientsRecurrent venous thromboembolismObese patientsVenous thromboembolismFactor Xa inhibitorsK antagonistsXa inhibitorsTreating morbidly obese patientsVitamin K antagonist groupNon-major bleedingMeta-analysisTreat venous thromboembolismMeta-analysis of studiesHigh-risk populationAssociated with lower oddsRandomized controlled trialsOral anticoagulantsGoogle Scholar databasesMorbid obesityNo significant differenceLandmark trialsAtrial fibrillationContemporary Weekend Effect on Management and In-Hospital Outcomes of Non-ST Elevation Myocardial Infarction
Park D, Kanitsoraphan C, Sana M, Hu J, Vardar U, Nanna M, Vij A. Contemporary Weekend Effect on Management and In-Hospital Outcomes of Non-ST Elevation Myocardial Infarction. Cardiovascular Revascularization Medicine 2023, 50: 61-62. PMID: 36702666, DOI: 10.1016/j.carrev.2023.01.002.Peer-Reviewed Original Research
2022
Network Meta-Analysis Comparing Angiotensin Receptor-Neprilysin Inhibitors, Angiotensin Receptor Blockers, and Angiotensin-Converting Enzyme Inhibitors in Heart Failure With Reduced Ejection Fraction
Park D, An S, Attanasio S, Jolly N, Malhotra S, Doukky R, Samsky M, Sen S, Ahmad T, Nanna M, Vij A. Network Meta-Analysis Comparing Angiotensin Receptor-Neprilysin Inhibitors, Angiotensin Receptor Blockers, and Angiotensin-Converting Enzyme Inhibitors in Heart Failure With Reduced Ejection Fraction. The American Journal Of Cardiology 2022, 187: 84-92. PMID: 36459752, PMCID: PMC10958453, DOI: 10.1016/j.amjcard.2022.10.026.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsBayes TheoremDeathHeart FailureHumansHypotensionNeprilysinNetwork Meta-AnalysisRandomized Controlled Trials as TopicReceptors, AngiotensinStroke VolumeTreatment OutcomeVentricular Dysfunction, LeftConceptsAngiotensin receptor neprilysin inhibitorAngiotensin receptor blockersReduced ejection fractionHeart failureEjection fractionHigh riskCause mortalityReceptor blockersCardiac deathLower riskEnzyme inhibitorsMajor adverse cardiac eventsAngiotensin converting enzyme (ACE) inhibitorsAdverse cardiac eventsEfficacy end pointNetwork meta-analysis approachImproved clinical outcomesRandomized clinical trialsP scoreCardiac eventsAngiotensin receptorsClinical outcomesNeprilysin inhibitorClinical benefitRecent trialsReadmission and adverse outcomes after percutaneous coronary intervention in patients with dementia
Park D, Hu J, Alexander K, Nanna M. Readmission and adverse outcomes after percutaneous coronary intervention in patients with dementia. Journal Of The American Geriatrics Society 2022, 71: 1034-1046. PMID: 36409823, PMCID: PMC10089937, DOI: 10.1111/jgs.18120.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionInhospital adverse eventsKidney injuryAdverse eventsCoronary interventionAdverse outcomesHigher readmission riskMultivariable Cox modelingAcute kidney injuryThirty-day readmissionIschemic heart diseaseCox proportional hazardsLogistic regression modelingDiagnosis of dementiaInhospital mortalityNoncardiac proceduresIndex hospitalizationReadmission ratesCox modelingReadmission riskCardiac arrestHeart diseasePCI experienceHigher oddsReadmissionReadmission rates and risk factors for readmission after transcatheter aortic valve replacement in patients with end-stage renal disease
Park DY, An S, Hanna JM, Wang SY, Cruz-Solbes AS, Kochar A, Lowenstern AM, Forrest JK, Ahmad Y, Cleman M, Al Damluji A, Nanna MG. Readmission rates and risk factors for readmission after transcatheter aortic valve replacement in patients with end-stage renal disease. PLOS ONE 2022, 17: e0276394. PMID: 36264931, PMCID: PMC9584363, DOI: 10.1371/journal.pone.0276394.Peer-Reviewed Original ResearchConceptsEnd-stage renal diseaseTranscatheter aortic valve replacementLength of stayAortic valve replacementIndex hospitalizationHospital mortalityReadmission ratesValve replacementRenal diseaseLonger LOSNational Readmission DatabaseRisk of readmissionChronic pulmonary diseaseMultivariable logistic regressionCardiovascular causesCardiovascular readmissionCause readmissionHospital readmissionPulmonary diseaseHospital chargesPoor outcomeRisk factorsHospital costsReadmissionHigher oddsPulmonary Embolism Readmission Trend Over the Years (from a National Readmission Database)
Murthi M, Velagapudi S, Park D, Shaka H. Pulmonary Embolism Readmission Trend Over the Years (from a National Readmission Database). The American Journal Of Cardiology 2022, 184: 133-140. PMID: 36167737, DOI: 10.1016/j.amjcard.2022.08.025.Peer-Reviewed Original ResearchConceptsPulmonary embolismUpper gastrointestinal bleedingAcute PEGastrointestinal bleedingPrincipal diagnosis of acute PEDiagnosis of acute PEMultivariate Cox regression modelPE-related complicationsCox regression modelsNational Readmission DatabaseStatistically significant decreasePrincipal admissionIntracranial bleedingIntracranial hemorrhageBleedingHospitalized patientsReadmissions DatabaseProportion of readmissionsSignificant decreaseConfounding factorsReadmissionCohortPrincipal diagnosisPatientsReadmission and In-Hospital Outcomes After Transcatheter Aortic Valve Replacement in Patients With Dementia
Park DY, Sana MK, Shoura S, Hammo H, Hu JR, Forrest JK, Lowenstern A, Cleman M, Ahmad Y, Nanna MG. Readmission and In-Hospital Outcomes After Transcatheter Aortic Valve Replacement in Patients With Dementia. Cardiovascular Revascularization Medicine 2022, 46: 70-77. PMID: 35973922, PMCID: PMC10940024, DOI: 10.1016/j.carrev.2022.08.016.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementAortic valve replacementAortic stenosisValve replacementSecondary diagnosisHospital adverse outcomesAcute kidney injuryIn-Hospital OutcomesNational Readmission DatabasePresence of dementiaPrevalence of dementiaProportional hazards modelDecade of ageHigher hazardIndex hospitalizationInpatient outcomesKidney injuryDefinitive treatmentPacemaker placementReadmission riskAdverse outcomesReadmissionHigher oddsDecision-making discussionsHigh riskIn-hospital prognosis of malignancy-related pulmonary embolism: an analysis of the national inpatient sample 2016–2018
Park D, An S, Kashoor I, Ezegwu O, Gupta S. In-hospital prognosis of malignancy-related pulmonary embolism: an analysis of the national inpatient sample 2016–2018. Journal Of Thrombosis And Thrombolysis 2022, 54: 630-638. PMID: 35876942, DOI: 10.1007/s11239-022-02684-8.Peer-Reviewed Original ResearchConceptsOdds of in-hospital mortalityIn-hospital mortalityAssociated with higher oddsPulmonary embolismNational Inpatient SamplePropensity score matchingEsophageal cancerLung cancerHigher oddsInpatient SamplePrognosis of PEScore matchingDiagnosis of PEClinically relevant covariatesPrimary diagnosis of PEMalignant groupOvarian cancerRetrospective studyMalignancyPrimary diagnosisRelevant covariatesCancerOddsPatientsMortalityAbbreviated versus Standard Duration of DAPT after PCI: A Systematic Review and Network Meta-analysis
Park D, An S, Kumar A, Malhotra S, Jolly N, Kaur A, Kattoor A, Doukky R, Kalra A, Vij A. Abbreviated versus Standard Duration of DAPT after PCI: A Systematic Review and Network Meta-analysis. American Journal Of Cardiovascular Drugs 2022, 22: 633-645. PMID: 35781867, DOI: 10.1007/s40256-022-00541-w.Peer-Reviewed Original ResearchConceptsNet adverse clinical eventsDuration of DAPTPercutaneous coronary interventionNetwork meta-analysisShorter duration of DAPTStent thrombosisMyocardial infarctionDrug-eluting stentsMeta-analysisResultsSeventeen randomized controlled trialsSystematic reviewAdverse cardiac eventsAdverse clinical eventsFrequentist network meta-analysesRisk of myocardial infarctionBackgroundDual antiplatelet therapyMonths of DAPTRandomized controlled trialsRandom-effects modelNetwork meta-analysesClinical presentationNo significant differenceAntiplatelet therapyMethodsThe present studyCardiac eventsMyocarditis after COVID‐19 mRNA vaccination: A systematic review of case reports and case series
Park D, An S, Kaur A, Malhotra S, Vij A. Myocarditis after COVID‐19 mRNA vaccination: A systematic review of case reports and case series. Clinical Cardiology 2022, 45: 691-700. PMID: 35652390, PMCID: PMC9286338, DOI: 10.1002/clc.23828.Peer-Reviewed Original ResearchConceptsCOVID-19 vaccine-associated myocarditisVaccine-associated myocarditisCOVID-19 mRNA vaccinesMRNA vaccinesSystematic review of case reportsCOVID-19 vaccineReview of case reportsAverage time to onsetElevation of troponinNonsteroidal anti-inflammatory drugsCases of myocarditisDisease severity of COVID-19Time to onsetLength of hospitalizationOccurrence of myocarditisDose of COVID vaccineAnti-inflammatory drugsPain 3Severity of COVID-19Anti-COVID-19 vaccineSystematic literature searchChest painFavorable prognosisCase seriesClinical characteristicsShortening the duration of dual antiplatelet therapy after percutaneous coronary intervention for acute coronary syndrome: A systematic review and meta-analysis
Park DY, Wang P, An S, Grimshaw AA, Frampton J, Ohman EM, Rao SV, Nanna MG. Shortening the duration of dual antiplatelet therapy after percutaneous coronary intervention for acute coronary syndrome: A systematic review and meta-analysis. American Heart Journal 2022, 251: 101-114. PMID: 35654162, PMCID: PMC10904033, DOI: 10.1016/j.ahj.2022.05.019.Peer-Reviewed Original ResearchConceptsMonths of DAPTHazard ratioIschemic eventsDuration of DAPTSelect patient characteristicsDual antiplatelet therapyAcute coronary syndromeCoronary artery lesionsPercutaneous coronary interventionConfidence intervalsAssociation of outcomesRandom-effects modelComprehensive literature searchMeta-regression analysisMajor bleedingAntiplatelet therapyCoronary syndromeArtery lesionsCoronary interventionControlled TrialsPatient characteristicsPrespecified outcomesGreater proportionSimilar efficacySystematic reviewIncidence and risk factors of atrial fibrillation and atrial arrhythmias in people living with HIV: a systematic review and meta-analysis
Park D, An S, Romero M, Kaur A, Ravi V, Huang H, Vij A. Incidence and risk factors of atrial fibrillation and atrial arrhythmias in people living with HIV: a systematic review and meta-analysis. Journal Of Interventional Cardiac Electrophysiology 2022, 65: 183-191. PMID: 35610524, DOI: 10.1007/s10840-022-01233-w.Peer-Reviewed Original ResearchConceptsRisk of atrial arrhythmiasAtrial arrhythmiasRisk factorsIncidence rateHIV infectionManaging cardiovascular risk factorsAssociated with decreased riskEfficacious antiretroviral therapyAtrial fibrillationMeta-Analysis guidelinesBurden of atrial arrhythmiasRisk factors of atrial fibrillationIncreased risk of atrial arrhythmiasTreatment of HIV infectionCardiovascular risk factorsRandom-effects modelCases of atrial arrhythmiasPotential risk factorsBackgroundCardiovascular diseaseIncreased viral loadPooled summary statisticsIncreasing burdenData extractionGeneral populationSystematic review