2007
Prenatal exposure to cocaine is associated with increased number of spine synapses in rat prelimbic cortex
Morrow BA, Hajszan T, Leranth C, Elsworth JD, Roth RH. Prenatal exposure to cocaine is associated with increased number of spine synapses in rat prelimbic cortex. Synapse 2007, 61: 862-865. PMID: 17630673, DOI: 10.1002/syn.20430.Peer-Reviewed Original ResearchConceptsPrenatal exposureFemale ratsSpine synapsesPrelimbic cortexDendritic spinesCognitive deficitsLayers II/IIIPrenatal saline controlsExcitatory synaptic inputsAsymmetric spine synapsesPrenatal cocaine exposureRat prelimbic cortexYoung adult malesPhysical disector methodPyramidal neuronsSaline controlsNeuronal activationCocaine exposureExcitatory synapsesFrontal cortexSynaptic inputsAnimal modelsExcess activationPrefrontal cortexCortex
2005
The Environmental Estrogen Bisphenol A Inhibits Estradiol-Induced Hippocampal Synaptogenesis
MacLusky NJ, Hajszan T, Leranth C. The Environmental Estrogen Bisphenol A Inhibits Estradiol-Induced Hippocampal Synaptogenesis. Environmental Health Perspectives 2005, 113: 675-679. PMID: 15929888, PMCID: PMC1257590, DOI: 10.1289/ehp.7633.Peer-Reviewed Original ResearchConceptsEnvironmental BPA exposureHippocampal synapse formationDendritic spine synapsesEndogenous estrogen productionHuman exposureNormal sex differencesHippocampus-dependent memoryHippocampal synaptogenesisOvariectomized ratsPyramidal neuronsBPA doseCA1 areaEstrogen productionSpine synapsesBPA exposureSignificant inhibitory effectSynaptic remodelingHippocampal functionSynapse formationCognitive functionNormal agingRapid effectsInhibitory effectManufacture of plasticsDental prostheses