2024
Physical space of thirty pediatric intensive care units in the United States of America: a national survey
Karam O, Ahmed A, Bizzarro M, Bogue C, Giuliano J, Collaborative P, Al-Subu A, Bateman S, Berning E, Brown K, Bulut Y, Cheifetz I, Chegondi M, Cholette J, Cowl A, Ceneviva G, Gehlbach J, Hobson M, Kudchadkar S, Labarinas S, Louis C, Miller M, Marinello M, Malone M, Nair A, Nishisaki A, Lowrie L, Rehder K, Rozenfeld R, Schneider J, Sequeira J, Shein S, Stalets E, Taylor J, Yager P. Physical space of thirty pediatric intensive care units in the United States of America: a national survey. Frontiers In Pediatrics 2024, 12: 1473805. PMID: 39359742, PMCID: PMC11445063, DOI: 10.3389/fped.2024.1473805.Peer-Reviewed Original ResearchRoom sizePediatric intensive care unitPhysical spaceConstruction of hospitalsIntensive care unitBuilding yearDesign practiceCare unitBuildings dateRoom designPrivate bathroomsOccupancy rateDouble roomRenovationBathroomCompliant unitsRoom characteristicsAmenitiesDesignConstructionIntermediate care unitCardiac ICUClinical outcomesInterquartile rangeUnit types
2015
Race, Ethnicity, and Socioeconomic Status in Research on Child Health
Cheng T, Goodman E, Cheng T, Bogue C, Chien A, Dean J, Kharbanda A, Peeples E, Scheindlin B. Race, Ethnicity, and Socioeconomic Status in Research on Child Health. Pediatrics 2015, 135: e225-e237. PMID: 25548336, PMCID: PMC9923597, DOI: 10.1542/peds.2014-3109.Peer-Reviewed Original ResearchConceptsChild healthHealth care disparitiesSocioeconomic statusCare disparitiesHealth care outcomesAdult morbidityPotential confoundingCare outcomesBiologic mechanismsHealth outcomesAmerican AcademyLife courseHealth careAdolescent HealthMorbidityOutcomesHealthBiologic influencesEthnicityExtensive literature documentsMore researchAAPDisparitiesMisattribution of causalityStatus
2014
Declined Presentation Critical roles for the homeodomain transcription factor hhex in lymphoid commitment and self-renewal of hematpoietic and leukaemic stem cells
Shields B, Jackson J, Nasa C, Metcalf D, Bogue C, Alexander W, McCormack M. Declined Presentation Critical roles for the homeodomain transcription factor hhex in lymphoid commitment and self-renewal of hematpoietic and leukaemic stem cells. Experimental Hematology 2014, 42: s48. DOI: 10.1016/j.exphem.2014.07.181.Peer-Reviewed Original ResearchInfectious Disease-Associated Syndromes in the PICU
Lazar I, Bogue C. Infectious Disease-Associated Syndromes in the PICU. 2014, 567-575. DOI: 10.1007/978-1-4471-6416-6_36.Peer-Reviewed Original ResearchPromoting Education, Mentorship, and Support for Pediatric Research
Cabana M, Cheng T, Bauer A, Bogue C, Chien A, Dean J, Scheindlin B, Kelle A. Promoting Education, Mentorship, and Support for Pediatric Research. Pediatrics 2014, 133: 943-949. PMID: 24777211, PMCID: PMC8194448, DOI: 10.1542/peds.2014-0448.Peer-Reviewed Original ResearchConceptsPediatric researchAmerican AcademyChild health researchChild health policyEvidence-based medicineHealth policy researchChild healthMost pediatriciansHealth servicesHealth policyYoung adultsPediatric trainingSocial healthHealth researchPediatriciansHealthBasic scienceChildrenSpecific recommendationsUnique issuesInfantsPediatricsFull spectrum
2010
Embryology and Development of the Ductal Plate
Bogue C. Embryology and Development of the Ductal Plate. Clinical Gastroenterology 2010, 3-21. DOI: 10.1007/978-1-60327-524-8_1.Peer-Reviewed Original ResearchFibrocystic diseaseDuctal plateExtrahepatic biliary tractIntrahepatic biliary treeBiliary developmentDefinitive treatmentBiliary atresiaBiliary tractBiliary treeBile productionHepatobiliary disordersExciting new knowledgeLiverDiseaseMolecular pathwaysHepatoblast differentiationEmbryological developmentDisordersCurrent knowledgeTreatmentCritical rolePathwayAtresiaEarly developmentTranscription factors
2008
The Proline-Rich Homeodomain (PRH/HEX) Protein Is Down-Regulated in Liver during Infection with Lymphocytic Choriomeningitis Virus
Djavani M, Topisirovic I, Zapata J, Sadowska M, Yang Y, Rodas J, Lukashevich I, Bogue C, Pauza C, Borden K, Salvato M. The Proline-Rich Homeodomain (PRH/HEX) Protein Is Down-Regulated in Liver during Infection with Lymphocytic Choriomeningitis Virus. Journal Of Virology 2008, 82: 8954-8954. PMCID: PMC2519670, DOI: 10.1128/jvi.01304-08.Peer-Reviewed Original Research
2007
Conditional deletion of the homeobox gene Hhex in the mouse liver results in polycystic liver disease
Hunter M, Wilson C, Kaestner K, Bogue C. Conditional deletion of the homeobox gene Hhex in the mouse liver results in polycystic liver disease. The FASEB Journal 2007, 21: lb4-lb4. DOI: 10.1096/fasebj.21.6.lb4.Peer-Reviewed Original ResearchAdult mutant miceHepatic cystsMutant miceNormal biliary cellsMultiple hepatic cystsIntrahepatic bile ductsDuctal plate malformationPolycystic liver diseaseBlood serum levelsWeeks of ageEmbryonic day 18.5Cystic epithelial cellsDuct-like structuresBiliary injuryCre-loxP systemSerum levelsLiver diseaseBile ductBiliary originPortal tractsTotal bilirubinAlanine transferaseCytokeratin antibodiesDay 18.5Liver results
2001
Genetic Models of Respiratory Tract Development
Bogue C. Genetic Models of Respiratory Tract Development. 2001, 20013058: 59-89. DOI: 10.1201/b14019-7.Peer-Reviewed Original Research
2000
Immunocytochemical Characterization of Murine Hex, a Homeobox-Containing Protein
Ghosh B, Ganea G, Denson L, Iannucci R, Jacobs H, Bogue C. Immunocytochemical Characterization of Murine Hex, a Homeobox-Containing Protein. Pediatric Research 2000, 48: 634-638. PMID: 11044484, DOI: 10.1203/00006450-200011000-00014.Peer-Reviewed Original ResearchConceptsMouse embryosGlutathione S-transferase fusion proteinS-transferase fusion proteinDivergent homeobox genesWhole mouse embryosTerminal amino acidsHepatic specificationHex proteinHomeobox genesMouse developmentDefinitive endodermBlood islandsNuclear localizationEndodermal cellsFusion proteinHex expressionProtein presentCultured cellsAmino acidsWhole mountsConfocal microscopyHepatic diverticulumProteinEmbryosWestern blotHex expression suggests a role in the development and function of organs derived from foregut endoderm
Bogue C, Ganea G, Sturm E, Ianucci R, Jacobs H. Hex expression suggests a role in the development and function of organs derived from foregut endoderm. Developmental Dynamics 2000, 219: 84-89. PMID: 10974674, DOI: 10.1002/1097-0177(2000)9999:9999<::aid-dvdy1028>3.0.co;2-5.Peer-Reviewed Original ResearchConceptsExtrahepatic biliary ductsMature animalsMaintenance of functionThymus originatesAdult thyroidDorsal pancreatic budLung expressionBile ductBiliary ductsThymic expressionFunction of organsDuct epitheliumLungThyroidE16.5 embryosLiverEpithelial cellsThymusSeptum transversumMesenchymal cellsPotential roleHex expressionDetectable levelsPharyngeal pouchesOrgansDivergent homeobox gene Hex regulates promoter of the Na+-dependent bile acid cotransporter
Denson L, Karpen S, Bogue C, Jacobs H. Divergent homeobox gene Hex regulates promoter of the Na+-dependent bile acid cotransporter. AJP Gastrointestinal And Liver Physiology 2000, 279: g347-g355. PMID: 10915644, DOI: 10.1152/ajpgi.2000.279.2.g347.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceCarrier ProteinsCOS CellsGene Expression RegulationGenetic Complementation TestHepatoblastomaHomeodomain ProteinsHumansLiverLiver NeoplasmsMembrane Transport ProteinsMolecular Sequence DataMutagenesisOligonucleotide ProbesOrganic Anion Transporters, Sodium-DependentPromoter Regions, GeneticRatsRecombinant Fusion ProteinsSymportersTranscription FactorsTranscription, GeneticTumor Cells, CulturedConceptsHomeobox gene HexDivergent homeobox gene HexNtcp promoterHex proteinHep G2 cellsElectrophoretic mobility shift assaysMobility shift assaysHeterologous promoter constructsDominant-negative formG2 cellsSpecific nuclear proteinLuciferase reporter constructsNuclear proteinsGene promoterShift assaysCOS cellsBasal luciferase activityReporter constructsPromoter regionBile acid cotransporterPromoter constructsResponse elementNegative formPromoterAcid cotransporterHNF3β and GATA-4 transactivate the liver-enriched homeobox gene, Hex
Denson L, McClure M, Bogue C, Karpen S, Jacobs H. HNF3β and GATA-4 transactivate the liver-enriched homeobox gene, Hex. Gene 2000, 246: 311-320. PMID: 10767553, DOI: 10.1016/s0378-1119(00)00082-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCOS CellsDNADNA-Binding ProteinsGATA4 Transcription FactorGenes, HomeoboxHepatocyte Nuclear Factor 3-betaHomeodomain ProteinsHumansLiverLuciferasesMaleMiceMolecular Sequence DataNuclear ProteinsPlasmidsPromoter Regions, GeneticProtein BindingRatsRats, Sprague-DawleyRecombinant Fusion ProteinsSequence Analysis, DNASp1 Transcription FactorSp3 Transcription FactorTranscription FactorsTranscriptional ActivationTransfectionTumor Cells, Cultured
1999
Genomic structure, cDNA mapping, and chromosomal localization of the mouse homeobox gene, Hex
Ghosh B, Jacobs H, Wiedemann L, Brown A, Bedford F, Nimmakayalu M, Ward D, Bogue C. Genomic structure, cDNA mapping, and chromosomal localization of the mouse homeobox gene, Hex. Mammalian Genome 1999, 10: 1023-1025. PMID: 10501975, DOI: 10.1007/s003359901152.Peer-Reviewed Original ResearchAmino Acid SequenceAnimalsBase SequenceChromosome MappingCloning, MolecularCrosses, GeneticGenes, HomeoboxGenetic LinkageGenetic MarkersHomeodomain ProteinsIn Situ Hybridization, FluorescenceLiverMiceMice, Inbred StrainsMolecular Sequence DataRestriction MappingSequence AnalysisTranscription FactorsPain management and weaning from narcotics and sedatives
Ganea G, Bogue C. Pain management and weaning from narcotics and sedatives. Current Opinion In Pediatrics 1999, 11: 207-212. PMID: 10349097, DOI: 10.1097/00008480-199906000-00006.Peer-Reviewed Original ResearchMultiple Factors Regulate the Promoter Region of the Liver-Enriched Orphan Homeobox Protein, Hex
Denson L, Ghosh B, McClure M, Bogue C, Karpen S, Jacobs H. Multiple Factors Regulate the Promoter Region of the Liver-Enriched Orphan Homeobox Protein, Hex. Pediatric Research 1999, 45: 110-110. DOI: 10.1203/00006450-199904020-00654.Peer-Reviewed Original Research
1998
Fetal Lung mRNA Levels of Hox Genes Are Differentially Altered by Maternal Diabetes and Butyrate in Rats
Jacobs H, Bogue C, Pinter E, Wilson C, Warshaw J, Gross I. Fetal Lung mRNA Levels of Hox Genes Are Differentially Altered by Maternal Diabetes and Butyrate in Rats. Pediatric Research 1998, 44: 99-104. PMID: 9667378, DOI: 10.1203/00006450-199807000-00016.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsButyratesButyric AcidDiabetes Mellitus, ExperimentalEmbryonic and Fetal DevelopmentFemaleGene Expression Regulation, DevelopmentalGenes, HomeoboxGestational AgeHistone Deacetylase InhibitorsLungOrgan Culture TechniquesPregnancyPregnancy in DiabeticsRatsRats, Sprague-DawleyRNA, MessengerTranscription, GeneticConceptsLung developmentLung explantsSurfactant apoproteinExperimental animalsLung mRNA levelsElevated levelsEffect of diabetesFetal rat lung explantsLungs of fetusesRat lung explantsEffect of butyrateAntenatal exposureMaternal diabetesMetabolic abnormalitiesStreptozotocin treatmentLower incidenceNormal ratsDiabetesDexamethasoneLevel of expressionRatsTreatment of explantsSodium butyrateMRNA levelsAlters expressionUse of high-frequency and nonconventional ventilation for respiratory failure
Donnelly K, Bogue C. Use of high-frequency and nonconventional ventilation for respiratory failure. Current Opinion In Pediatrics 1998, 10: 278-283. PMID: 9716890, DOI: 10.1097/00008480-199806000-00010.Peer-Reviewed Original ResearchConceptsRespiratory failureAcute lung injuryPartial liquid ventilationCare of patientsTracheal gas insufflationHigh-frequency ventilationNonconventional ventilationLung injuryProne positioningIll patientsFrequency ventilationLiquid ventilationGas insufflationVentilationNew modalityPatientsRecent dataModalitiesMorbidityFailureInsufflationInjuryMortalityCareHex Expression During Development Suggests an Important Role in Both Gastrulation and Organogenesis • 251
Bogue C, Ganea G, Sturm E, Zhao F, Jacobs H. Hex Expression During Development Suggests an Important Role in Both Gastrulation and Organogenesis • 251. Pediatric Research 1998, 43: 45-45. DOI: 10.1203/00006450-199804001-00272.Peer-Reviewed Original ResearchThe Na+-dependent bile acid cotransporter (NTCP) is a putative target gene for the liver-enriched, orphan homeobox protein, Hex • 581
Jacobs H, Denson T, Karpen S, Bogue C. The Na+-dependent bile acid cotransporter (NTCP) is a putative target gene for the liver-enriched, orphan homeobox protein, Hex • 581. Pediatric Research 1998, 43: 102-102. DOI: 10.1203/00006450-199804001-00602.Peer-Reviewed Original Research