2024
The Melanocortin and Endorphin Neuropeptides in Patients with Restless Legs Syndrome
Koo B, Abdelfattah A, Eysa A, Lu L. The Melanocortin and Endorphin Neuropeptides in Patients with Restless Legs Syndrome. Annals Of Neurology 2024, 95: 688-699. PMID: 38308537, DOI: 10.1002/ana.26876.Peer-Reviewed Original ResearchRestless legs syndromeRestless legs syndrome patientsRestless legs syndrome severityAdrenocorticotropin hormoneCerebrospinal fluidB-endorphinPro-opiomelanocortinA-MSHPlasma adrenocorticotropin hormoneRLS participantsInternational RLS Study Group Severity ScaleRLS patientsAssessed plasmaPain symptomsLumbar punctureA-melanocyte-stimulating hormoneMatched controlsPatientsHormoneSeverity ScaleSensory discomfortPlasmaSeverityMelanocortin hormonesHyperalgesia
2023
Review of the role of the endogenous opioid and melanocortin systems in the restless legs syndrome
Walters A, Li Y, Koo B, Ondo W, Weinstock L, Champion D, Afrin L, Karroum E, Bagai K, Spruyt K. Review of the role of the endogenous opioid and melanocortin systems in the restless legs syndrome. Brain 2023, 147: 26-38. PMID: 37633259, PMCID: PMC10796165, DOI: 10.1093/brain/awad283.Peer-Reviewed Original ResearchConceptsRestless legs syndromeMu-opioid receptorsRLS patientsEndogenous opioidsLegs syndromeOpioid receptorsSerum ironΒ-endorphinMelanocortin systemIdiopathic restless legs syndromeRLS-like symptomsPeriodic limb movementsLow serum ironWild-type miceSensory changesMelanocyte stimulating hormoneReceptor blockersSerum ferritinAutopsy studyStriatal dopamineAdrenocorticotropic hormoneStimulating hormoneDopaminergic systemMouse modelTherapeutic efficacy
2018
0661 Suicidal Behavior in Restless Legs Syndrome
Para K, Chow C, Kakade V, Nalamada K, Chilakamarri P, Louis E, KOO B. 0661 Suicidal Behavior in Restless Legs Syndrome. Sleep 2018, 41: a245-a245. DOI: 10.1093/sleep/zsy061.660.Peer-Reviewed Original ResearchRestless legs syndromeLifetime depression historyLifetime suicidal thoughtsControl subjectsSuicidal behaviorLegs syndromeDepression historyBrief Lifetime Depression ScaleInternational RLS Severity ScaleSuicidal thoughtsRLS severity scaleLifetime suicidal behaviorHigh suicide riskSuicide risk factorsOverall cohortRLS patientsRLS severityDopamine agonistsRisk factorsRLS subjectsSuicidal planningDepression ScaleSuicidal Behaviors QuestionnaireSeverity ScaleRLS cohort
2016
Restless Legs Syndrome: Current Concepts about Disease Pathophysiology
Koo BB, Bagai K, Walters AS. Restless Legs Syndrome: Current Concepts about Disease Pathophysiology. Tremor And Other Hyperkinetic Movements 2016, 6: 401. PMID: 27536462, PMCID: PMC4961894, DOI: 10.7916/d83j3d2g.Peer-Reviewed Original ResearchRestless legs syndromeBrain areasLegs syndromeSerotonergic systemCingulate cortexIron deficiencyStructural brain abnormalitiesPost-central gyrusWidespread brain areasSensory brain areasEnglish language papersRLS patientsSensorimotor disorderBrain abnormalitiesAnatomic locationDisease pathophysiologySecondary responseBrain regionsPathophysiologyConsistent findingLanguage papersCurrent conceptsOpioidsGlutamatergicDopaminergicRestless Legs Syndrome: Current Concepts about Disease Pathophysiology
Koo B, Bagai K, Walters A. Restless Legs Syndrome: Current Concepts about Disease Pathophysiology. Tremor And Other Hyperkinetic Movements 2016, 6: 401. DOI: 10.5334/tohm.322.Peer-Reviewed Original ResearchRestless legs syndromeBrain areasLegs syndromeSerotonergic systemCingulate cortexIron deficiencyStructural brain abnormalitiesPost-central gyrusWidespread brain areasSensory brain areasEnglish language papersRLS patientsSensorimotor disorderBrain abnormalitiesAnatomic locationDisease pathophysiologySecondary responseBrain regionsPathophysiologyConsistent findingLanguage papersCurrent conceptsOpioidsGlutamatergicDopaminergic