2022
Liquid–liquid phase separation facilitates the biogenesis of secretory storage granules
Parchure A, Tian M, Stalder D, Boyer C, Bearrows S, Rohli K, Zhang J, Rivera-Molina F, Ramazanov B, Mahata S, Wang Y, Stephens S, Gershlick D, von Blume J. Liquid–liquid phase separation facilitates the biogenesis of secretory storage granules. Journal Of Cell Biology 2022, 221: e202206132. PMID: 36173346, PMCID: PMC9526250, DOI: 10.1083/jcb.202206132.Peer-Reviewed Original ResearchMeSH KeywordsChromograninsCytoplasmic GranulesGolgi ApparatusHumansInsulinInsulin-Secreting CellsProinsulinSecretory VesiclesConceptsTrans-Golgi networkLiquid-liquid phase separationSecretory granulesClient moleculesSecretory storage granulesΒ-cellsMembrane traffickingCargo receptorsPlasma membranePancreatic β-cellsProcessing enzymesCell typesStorage granulesChromogranin proteinsBiogenesisAcidic pHTraffickingGranulesProteinEnzyme
2017
Getting mRNA-Containing Ribonucleoprotein Granules Out of a Nuclear Back Door
Parchure A, Munson M, Budnik V. Getting mRNA-Containing Ribonucleoprotein Granules Out of a Nuclear Back Door. Neuron 2017, 96: 604-615. PMID: 29096075, DOI: 10.1016/j.neuron.2017.10.020.Peer-Reviewed Original ResearchMeSH KeywordsActive Transport, Cell NucleusAnimalsCell NucleusCytoplasmic GranulesHumansNuclear EnvelopeRibonucleoproteinsRNA, MessengerConceptsNuclear pore complexNE buddingNuclear envelope buddingProtein synthesis machineryLocalization of RNAEndogenous cellular processesNuclear escapeLarge RNPsPore complexSynthesis machineryNuclear assemblyTransport granulesCellular processesNuclear exportSynaptic plasticityProtein aggregatesBuddingViral capsidRecent findingsSynthetic activitySynaptic sitesRecent studiesPlasticityDrosophilaRibonucleoprotein