2020
Lower Urinary Pathogens: Do More Pathogenic Bacteria Increase the Risk of Pyelonephritis?
Rosett HA, Krischak MK, Sachdeva S, Weaver KE, Heine RP, Denoble AE, Dotters-Katz SK. Lower Urinary Pathogens: Do More Pathogenic Bacteria Increase the Risk of Pyelonephritis? American Journal Of Perinatology 2020, 39: 473-478. PMID: 32971563, DOI: 10.1055/s-0040-1717093.Peer-Reviewed Original ResearchConceptsLower urinary tract infectionsHistory of preeclampsiaPreterm birthPregnant womenLow birthweightPathogenic infectionsOutside of pregnancyRisk of pyelonephritisOdds of progressionSingle tertiary centerPreterm birth rateRisk of progressionUrinary tract infectionBody mass indexRate of progressionHistory of pyelonephritisAsymptomatic bacteriuriaChronic hypertensionMedian LOSObstetric outcomesUrinary culturePostpartum dataRetrospective cohortSecondary outcomesTract infections
2011
Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation
Denoble AE, Huffman KM, Stabler TV, Kelly SJ, Hershfield MS, McDaniel GE, Coleman RE, Kraus VB. Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 2088-2093. PMID: 21245324, PMCID: PMC3033282, DOI: 10.1073/pnas.1012743108.Peer-Reviewed Original ResearchConceptsIL-18OA severityIL-1βUric acidOA progressionSynovial fluid IL-1βCohort of subjectsKnee OA severityInnate immune systemKnee osteoarthritisBone scintigraphyNLRP3 inflammasomeOA pathologyInflammasome activationDanger signalsImmune systemOsteoarthritisRadiographsSeverityPotential involvementInflammasomeProgressionScintigraphyNLRP3Cytokines