Allelic exclusion in transgenic mice carrying mutant human IgM genes.
Nussenzweig MC, Shaw AC, Sinn E, Campos-Torres J, Leder P. Allelic exclusion in transgenic mice carrying mutant human IgM genes. Journal Of Experimental Medicine 1988, 167: 1969-1974. PMID: 3133444, PMCID: PMC2189689, DOI: 10.1084/jem.167.6.1969.Peer-Reviewed Original ResearchConceptsAllelic exclusionHeavy chain geneChain geneMu chainsHuman mu chainsPrimary B cellsHybrid animalsIg heavy chain genesHuman heavy chainsMu expressionTransgenic mice resultsIgM geneGenesSimultaneous expressionSecreted versionTransgeneIg transgenesHeavy chainMice resultsTransgenic miceExpressionHuman Ig transgenesB cellsCellsVivo