2025
Bidirectional relationship between epigenetic age and stroke, dementia, and late-life depression
Rivier C, Szejko N, Renedo D, Clocchiatti-Tuozzo S, Huo S, de Havenon A, Zhao H, Gill T, Sheth K, Falcone G. Bidirectional relationship between epigenetic age and stroke, dementia, and late-life depression. Nature Communications 2025, 16: 1261. PMID: 39893209, PMCID: PMC11787333, DOI: 10.1038/s41467-024-54721-0.Peer-Reviewed Original ResearchThis study shows a bidirectional link between accelerated epigenetic aging and brain health events like stroke, dementia, and depression, supporting new prevention strategies for aging-related conditions.A failure to launch: blood pressure control after stroke in a regional health system
Forman R, Xin X, Kim C, Kernan W, Sheth K, Krumholz H, de Havenon A, Spatz E, Lu Y. A failure to launch: blood pressure control after stroke in a regional health system. Journal Of Hypertension 2025, 43: 715-718. PMID: 39995224, DOI: 10.1097/hjh.0000000000003961.Peer-Reviewed Original ResearchConceptsYale New Haven Health SystemRegional health systemHealth systemSystolic blood pressureDiastolic blood pressureMonths post strokeAverage proportion of patientsBP controlPost strokeBlood pressureProfessional visitsPrimary outcomeBlood pressure controlProportion of patientsAverage proportionVisitsSBP valuesEpic systemPressure controlStrokePatientsGlobal budgetEffect of glucagon-like peptide-1 receptor agonists on vascular risk factors among adults with type 2 diabetes and established atherosclerotic cardiovascular disease
King A, Tan X, Dhopeshwarkar N, Bohn R, Dea K, Leonard C, de Havenon A. Effect of glucagon-like peptide-1 receptor agonists on vascular risk factors among adults with type 2 diabetes and established atherosclerotic cardiovascular disease. American Journal Of Preventive Cardiology 2025, 21: 100922. PMID: 39896054, PMCID: PMC11786665, DOI: 10.1016/j.ajpc.2024.100922.Peer-Reviewed Original ResearchVascular risk factorsGLP-1 RAsRisk factorsType 2 diabetesAtherosclerotic cardiovascular diseaseUS electronic health records databaseElectronic health record databaseOW GLP-1 RAsRisk factor valuesHealth record databaseCardiovascular diseaseReal-world practiceBody mass indexOnce-weeklyEffects of glucagon-like peptide-1 receptor agonistsGlucagon-like peptide-1 receptor agonistsGLP-1Systolic blood pressureLow-density lipoprotein cholesterolPeptide-1 receptor agonistsEffects of once-weeklyMass indexRecord databaseSignificant mean reductionAssociated with significant reductions
2024
Lipid-Lowering Therapy Use When Indicated and Subsequent Ischemic Stroke Severity.
Gordon-Kundu B, Peyravi R, Garg A, Baker A, Salas S, Levien M, Faridi K, de Havenon A, Krumholz H, Sheth K, Forman R, Sharma R. Lipid-Lowering Therapy Use When Indicated and Subsequent Ischemic Stroke Severity. Journal Of The American Heart Association 2024, 14: e033365. PMID: 39699007, DOI: 10.1161/jaha.123.033365.Peer-Reviewed Original ResearchConceptsPrescribed lipid-lowering therapyNational Institutes of Health Stroke Scale scoreAcute ischemic strokeLipid-lowering therapyStroke Scale scoreStroke severityGuidelines-Stroke registryAtherosclerotic cardiovascular disease eventsCardiovascular disease eventsScale scoreGuideline-recommended criteriaSevere stroke symptomsStudy assessed usePropensity score subclassificationLipid-lowering therapy useNational InstituteLogistic regression modelsCholesterol management guidelinesPoststroke disabilityElevated low-density lipoprotein cholesterolInstitutional GetSmall vessel diseaseTime of acute ischemic strokeLarge-artery atherosclerosisLow-density lipoprotein cholesterolCardiovascular Events in Adults with Type 2 Diabetes and ASCVD Initiating Once-Weekly Semaglutide vs DPP-4is in the USA
Inzucchi S, Tan X, Liang Y, Yedigarova L, Xie L, de Havenon A. Cardiovascular Events in Adults with Type 2 Diabetes and ASCVD Initiating Once-Weekly Semaglutide vs DPP-4is in the USA. Diabetes Therapy 2024, 16: 187-203. PMID: 39688779, PMCID: PMC11794941, DOI: 10.1007/s13300-024-01678-4.Peer-Reviewed Original ResearchHealth care resource utilizationAtherosclerotic cardiovascular diseaseDPP-4i usersDPP-4isGLP-1 RAsOnce-weekly semaglutideMedical costsType 2 diabetesDPP-4iDecreased risk of strokeRisk of cardiovascular outcomesCardiovascular eventsOnce-weekly GLP-1 RAsPeptide 1 receptor agonistsTotal medical costsDipeptidyl peptidase 4 inhibitorsOccurrence of cardiovascular eventsHigh-risk patientsRisk of strokeObservational cohort analysisData Mart DatabaseOutpatient visitsDecreased riskSemaglutide treatmentBaseline characteristicsHow Much More Time Neurologic Examination Adds to Outpatient Visits
Ney J, Wilson A, Raphaelson M, de Havenon A. How Much More Time Neurologic Examination Adds to Outpatient Visits. Neurology Clinical Practice 2024, 15: e200404. PMID: 39649023, PMCID: PMC11620545, DOI: 10.1212/cpj.0000000000200404.Peer-Reviewed Original ResearchSurvey design variablesPatient visitsNational Ambulatory Medical Care SurveyStrong doctor-patient relationshipCost of careDoctor-patient relationshipSubgroup analysisNeurological examinationMedical decision makingNeurologist visitCare SurveyAmbulatory careInsurance statusOutpatient visitsPatient accessAnnual visitsLonger visitsVisit informationGeographic regionsVisit timeNeurological diagnosisVisitsPortable, low-field magnetic resonance imaging for evaluation of Alzheimer’s disease
Sorby-Adams A, Guo J, Laso P, Kirsch J, Zabinska J, Garcia Guarniz A, Schaefer P, Payabvash S, de Havenon A, Rosen M, Sheth K, Gomez-Isla T, Iglesias J, Kimberly W. Portable, low-field magnetic resonance imaging for evaluation of Alzheimer’s disease. Nature Communications 2024, 15: 10488. PMID: 39622805, PMCID: PMC11612292, DOI: 10.1038/s41467-024-54972-x.Peer-Reviewed Original ResearchConceptsWhite matter hyperintensitiesMachine learning pipelineMild cognitive impairmentAlzheimer's diseaseWhite matter hyperintensities volumeLearning pipelineAssessment of patientsIncrease accessCognitive impairmentEvaluation of Alzheimer's diseaseDementiaLF-MRIPoint-of-care assessmentMagnetic resonance imagingHippocampal volumeResonance imagingImage qualityDiseaseReduce costsAnisotropic counterpartIncreasing availabilityManual segmentationRecent advances in portable, low-field magnetic resonance imaging in cerebrovascular disease
Zabinska J, de Havenon A, Sheth K. Recent advances in portable, low-field magnetic resonance imaging in cerebrovascular disease. Current Opinion In Neurology 2024, 38: 35-39. PMID: 39624032, DOI: 10.1097/wco.0000000000001338.Peer-Reviewed Original ResearchConceptsCerebrovascular diseaseWhite matter hyperintensityHealthcare settingsHemorrhage managementAlzheimer's dementiaClinical timepointsStages of cerebrovascular diseaseHemorrhagic strokeEmergency settingWhite matter hyperintensitiesIntracerebral hemorrhage managementCardiovascular intensive careThrombolytic administrationPatient populationCerebrovascular disease progressionIntensive careMagnetic resonance imagingStrokeEndovascular reperfusionCerebrovascularCost-effectiveDisease progressionResonance imagingChronic stageCareOutcomes of Adjunct Emergent Stenting Versus Mechanical Thrombectomy Alone: The RESCUE-ICAS Registry
Al Kasab S, Almallouhi E, Jumaa M, Inoa V, Capasso F, Nahhas M, Starke R, Fragata I, Bender M, Moldovan K, Yaghi S, Maier I, Grossberg J, Jabbour P, Psychogios M, Samaniego E, Burkhardt J, Jankowitz B, Abdalkader M, Hassan A, Altschul D, Mascitelli J, Regenhardt R, Wolfe S, Ezzeldin M, Limaye K, Grandhi R, Al Jehani H, Niazi M, Goyal N, Tjoumakaris S, Alawieh A, Abdelsalam A, Guada L, Ntoulias N, El-Ghawanmeh R, Batra V, Choi A, Zohdy Y, Nguyen S, Essibayi M, Naamani K, Koo A, Almekhlafi M, Raz E, Miller S, Mierzwa A, Zaidi S, Gudino A, Alsarah A, Azeem H, Mattingly T, Schartz D, Nelson A, Pinheiro C, Spiotta A, Kicielinski K, Lena J, Lajthia O, Hubbard Z, Zaidat O, Derdeyn C, Klein P, Nguyen T, de Havenon A. Outcomes of Adjunct Emergent Stenting Versus Mechanical Thrombectomy Alone: The RESCUE-ICAS Registry. Stroke 2024, 56: 390-400. PMID: 39576761, DOI: 10.1161/strokeaha.124.049038.Peer-Reviewed Original ResearchConceptsPatients treated with mechanical thrombectomyStent groupMechanical thrombectomySymptomatic hemorrhageEmergency stentingConsecutive patients treated with mechanical thrombectomyIntracranial stenosisRate of symptomatic hemorrhageRisk of symptomatic hemorrhageModified Rankin Scale scoreAssociated with better functional outcomesInverse probability of treatment weightingProbability of treatment weightingRankin Scale scoreInternational cohort studyLarge vessel occlusionAcute ischemic strokeThrombectomy-capable centersComplication rateResidual stenosisCohort studyIncreased riskInfarct volumePrimary outcomeFunctional outcomesIncidental Detection of Previously Unknown Strokes on Head CT Examinations: An Untapped Opportunity for Secondary Prevention
Kenny-Howell C, Dixe de Oliveira Santo I, Wira C, de Havenon A, Tu L. Incidental Detection of Previously Unknown Strokes on Head CT Examinations: An Untapped Opportunity for Secondary Prevention. Journal Of The American College Of Radiology 2024 PMID: 39571646, DOI: 10.1016/j.jacr.2024.11.010.Peer-Reviewed Original ResearchHead CT imagesEmergency departmentOld strokeSecondary preventionHead CTCT imagesRetrospective study of adult patientsImplement secondary preventionStudy of adult patientsAssociated with greater ageHead CT examinationsED careRisk of recurrent strokeED encountersUnivariate regressionCerebellar locationCT examinationsRetrospective studyAdult patientsIncidental detectionUnivariate analysisIncidental discoveryGreater ageMultivariate regressionPatientsPolygenic Risk of Epilepsy and Poststroke Epilepsy
Clocchiatti-Tuozzo S, Rivier C, Misra S, Zelano J, Mazumder R, Sansing L, de Havenon A, Hirsch L, Liebeskind D, Gilmore E, Sheth K, Kim J, Worrall B, Falcone G, Mishra N. Polygenic Risk of Epilepsy and Poststroke Epilepsy. Stroke 2024, 55: 2835-2843. PMID: 39502073, PMCID: PMC11653790, DOI: 10.1161/strokeaha.124.047459.Peer-Reviewed Original ResearchParticipants of European ancestryRisk of poststroke epilepsyPolygenic riskPoststroke epilepsyEuropean ancestryGenome-wide association study meta-analysisPRS decileCase-control genetic association studyGenetic risk lociLowest decilePolygenic risk scoresGenetic association studiesMultivariate logistic regression modelStudy meta-analysisMultivariate logistic regression resultsHistory of strokeLogistic regression modelsRisk lociAssociation studiesStroke survivorsUK BiobankGenetic informationGenetic ancestryLogistic regression resultsGenetic variantsSex Modifies the Severity and Outcome of Spontaneous Intracerebral Hemorrhage
Rivier C, Renedo D, Marini S, Magid‐Bernstein J, de Havenon A, Rosand J, Hanley D, Ziai W, Mayer S, Woo D, Sansing L, Sheth K, Anderson C, Falcone G. Sex Modifies the Severity and Outcome of Spontaneous Intracerebral Hemorrhage. Annals Of Neurology 2024, 97: 232-241. PMID: 39499118, DOI: 10.1002/ana.27123.Peer-Reviewed Original ResearchRisk of hematoma expansionHighest risk of hematoma expansionRisk of poor outcomesIntracerebral hemorrhageHematoma expansionHigh riskMale sexPoor outcomeOutcome of spontaneous intracerebral hemorrhageClinical characteristics of patientsStudies of intracerebral hemorrhageNon-traumatic intracerebral hemorrhageIndividual patient data meta-analysisPatient data meta-analysisSpontaneous intracerebral hemorrhageSingle-center studyIntracerebral hemorrhage patientsHigh risk of expansionCharacteristics of patientsIntracerebral hemorrhage severityPoor functional outcomeRandomized clinical trialsData meta-analysisHemorrhage volumeClinical characteristicsIntracranial Atherosclerosis
Salas S, Lee K, De Havenon A. Intracranial Atherosclerosis. 2024, 197-206. DOI: 10.1007/978-3-031-66289-8_18.Peer-Reviewed Original ResearchAcute Stroke Treatment: Thrombectomy
Veltri N, Elnazer S, De Havenon A. Acute Stroke Treatment: Thrombectomy. 2024, 93-102. DOI: 10.1007/978-3-031-66289-8_9.Peer-Reviewed Original ResearchSmall Vessel Disease
Salas S, Lee K, De Havenon A. Small Vessel Disease. 2024, 207-211. DOI: 10.1007/978-3-031-66289-8_19.Peer-Reviewed Original ResearchLife's Essential 8 and Poor Brain Health Outcomes in Middle-Aged Adults
Clocchiatti-Tuozzo S, Rivier C, Renedo D, Huo S, Hawkes M, de Havenon A, Schwamm L, Sheth K, Gill T, Falcone G. Life's Essential 8 and Poor Brain Health Outcomes in Middle-Aged Adults. Neurology 2024, 103: e209990. PMID: 39442069, PMCID: PMC11498939, DOI: 10.1212/wnl.0000000000209990.Peer-Reviewed Original ResearchConceptsLife's Essential 8Poor cardiovascular healthCardiovascular healthBrain healthLife's Essential 8 scoreUnadjusted riskEssential 8Determinants of cardiovascular healthUK Biobank (UKBCardiovascular health profileModifiable cardiovascular risk factorsBrain health outcomesRisk factorsComposite outcomePublic health constructsPopulation studiesMiddle-aged adultsCox modelLate-life depressionCox proportional hazards modelsBrain health benefitsMultivariate Cox modelCardiovascular risk factorsFollow-up timeAoU participantsMigraine May Represent an Independent Risk Factor for Retinal Stroke: A Population-Based Cohort Study
Lusk J, Song A, Unnithan S, Al-Khalidi H, de Havenon A, Biousse V, Schrag M, Solopova E, Poli S, Osazuwa-Peters N, Xian Y, O'Brien E, Mac Grory B. Migraine May Represent an Independent Risk Factor for Retinal Stroke: A Population-Based Cohort Study. Clinical Neurology And Neurosurgery 2024, 246: 108587. PMID: 39405806, PMCID: PMC11527560, DOI: 10.1016/j.clineuro.2024.108587.Peer-Reviewed Original ResearchRetinal artery occlusionRetinal strokeRisk factorsCohort studyPopulation-based cohort studyState Emergency Department DatabasesPopulation-based dataEmergency Department DatabasesCause-specific hazard modelBurden of atrial fibrillationCongestive cardiac failureIndependent risk factorChronic kidney diseasePrimary exposureDepartment databasePrimary endpointSecondary endpointsCardiac failureAtrial fibrillationHazards modelRobust associationsArtery occlusionKidney diseaseMigraineDiagnostic positionsOutcomes and Recurrence Rates Among Patients With Provoked and Cryptogenic Cerebral Venous Thrombosis
Al Kasab S, Almallouhi E, Shu L, Kicielinski K, Salehi Omran S, Liebeskind D, Zubair A, Vedovati M, Paciaroni M, Antonenko K, Heldner M, de Havenon A, Henninger N, Yaghi S. Outcomes and Recurrence Rates Among Patients With Provoked and Cryptogenic Cerebral Venous Thrombosis. Neurology Clinical Practice 2024, 15: e200381. PMID: 39399562, PMCID: PMC11464219, DOI: 10.1212/cpj.0000000000200381.Peer-Reviewed Original ResearchRisk of recurrent venous thromboembolismRecurrent venous thromboembolismCerebral venous thrombosisVenous thromboembolismFemale patientsVenous thrombosisBaseline characteristicsOutcome of cerebral venous thrombosisRate of recurrent venous thromboembolismProvoking factorsRare cause of strokeTransient provoking factorsKaplan-Meier survival analysisDuration of anticoagulationOutcomes of patientsMann-Whitney <i>Cause of strokeConsecutive patientsRare causeRecurrence rateMale patientsMulticenter studyRetrospective databaseStandard treatmentCox regressionRecent trends in GLP-1 RA and SGLT2i use among people with type 2 diabetes and atherosclerotic cardiovascular disease in the USA
King A, Tan X, Dhopeshwarkar N, Bohn R, Dea K, Leonard C, de Havenon A. Recent trends in GLP-1 RA and SGLT2i use among people with type 2 diabetes and atherosclerotic cardiovascular disease in the USA. BMJ Open Diabetes Research & Care 2024, 12: e004431. PMID: 39366717, PMCID: PMC11459310, DOI: 10.1136/bmjdrc-2024-004431.Peer-Reviewed Original ResearchConceptsSodium-glucose cotransporter 2 inhibitorsGLP-1 RAsAtherosclerotic cardiovascular diseaseGLP-1Type 2 diabetesIncident useGlucagon-like peptide-1 receptor agonistsPeptide-1 receptor agonistsCardiovascular diseasePrevalence of atherosclerotic cardiovascular diseaseASCVD diagnosisProportion of patientsRetrospective observational studyNested cohort studyReceptor agonistsSGLT2i useAnalysis of cross-sectional dataSodium-glucoseCohort studyPatient numbersObservational studyPatientsPrevalent useCross-sectional dataT2DSocioeconomic and medical determinants of state‐level subjective cognitive decline in the United States
de Havenon A, Stulberg E, Littig L, Wong K, Sarpong D, Li V, Sharma R, Falcone G, Williamson J, Pajewski N, Gottesman R, Brickman A, Sheth K. Socioeconomic and medical determinants of state‐level subjective cognitive decline in the United States. Alzheimer's & Dementia 2024, 20: 7567-7579. PMID: 39351858, PMCID: PMC11567845, DOI: 10.1002/alz.14220.Peer-Reviewed Original ResearchSubjective cognitive declinePrevalence of diabetesPrevalence of povertyMedical determinantsBehavioral Risk Factor Surveillance SystemRisk Factor Surveillance SystemCognitive declinePrevalence of subjective cognitive declineBurden of cognitive declinePopulation levelState-level prevalenceMedical risk factorsFunctional impairmentState-level associationsPhysician densityUnited StatesMedical factorsRates of povertyState-level analysisHousehold incomePrimary outcomeCollege educationSurveillance systemRisk factorsEthnic minorities
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