Siyuan Cheng
About
Research
Publications
2024
Activation of mechanoreceptor Piezo1 inhibits enteric neuronal growth and migration in vitro
Moneme C, Olutoye O, Sobstel M, Zhang Y, Zhou X, Kaminer J, Hsu B, Shen C, Mandal A, Li H, Yu L, Balaji S, Keswani S, Cheng L. Activation of mechanoreceptor Piezo1 inhibits enteric neuronal growth and migration in vitro. Frontiers In Molecular Neuroscience 2024, 17: 1474025. PMID: 39759870, PMCID: PMC11695422, DOI: 10.3389/fnmol.2024.1474025.Peer-Reviewed Original ResearchEnteric nervous systemEnteric neuronsNeuronal migrationNeural crest-derived progenitor cellsPiezo1 activationNeuronal growthPiezo1 inhibitionENS dysfunctionNeurite lengthMigration in vitroPiezo1 agonistPiezo1 antagonistProgenitor cellsNeuronal phenotypeNeuronal recoveryMechanosensitive ion channelsGI functionPiezo1 expressionAdult mouse intestineGI tractMouse intestineNervous systemIon channelsNeuronal morphologyNeuronsImpact of the Grosfeld Career Development Award on the Academic Success of Pediatric Surgeon-Scientists
Olutoye O, Gyimah M, Degala A, Lee T, Keswani S, Kunisaki S, Cheng L. Impact of the Grosfeld Career Development Award on the Academic Success of Pediatric Surgeon-Scientists. Journal Of Pediatric Surgery 2024, 60: 161969. PMID: 39358074, DOI: 10.1016/j.jpedsurg.2024.161969.Peer-Reviewed Original ResearchHirschsprung disease: common and uncommon variants
Cheng L, Wood R. Hirschsprung disease: common and uncommon variants. World Journal Of Pediatric Surgery 2024, 7: e000864. PMID: 39224573, PMCID: PMC11367348, DOI: 10.1136/wjps-2024-000864.Peer-Reviewed Original ResearchA novel method for culturing enteric neurons generates neurospheres containing functional myenteric neuronal subtypes
Mandal A, Moneme C, Tewari B, Goldstein A, Sontheimer H, Cheng L, Moore S, Levin D. A novel method for culturing enteric neurons generates neurospheres containing functional myenteric neuronal subtypes. Journal Of Neuroscience Methods 2024, 407: 110144. PMID: 38670535, PMCID: PMC11144385, DOI: 10.1016/j.jneumeth.2024.110144.Peer-Reviewed Original ResearchEnteric neuronsEnteric nervous systemPresence of sodium channel blockersProgenitor cellsProgenitor cell marker nestinAction potentialsNeural progenitor cell markers nestinNeural stemMyenteric plexus cellsActivate enteric neuronsCultured enteric neuronsCells expressing Sox2Differentiation culture systemSodium channel blockersMurine small intestineNeural progenitor cellsTubulin beta IIIDays of differentiationChannel blockersDifferentiated neurospheresNeuN immunofluorescenceEnteric neurospheresNeuronal subtypesMarker nestinPlexus cells
2018
A sRNA in a reduced mutualistic symbiont genome regulates its own gene expression.
Thairu MW, Cheng S, Hansen AK. A sRNA in a reduced mutualistic symbiont genome regulates its own gene expression. Molecular Ecology 2018, 27: 1766-1776. PMID: 29134727, DOI: 10.1111/mec.14424.Peer-Reviewed Original Research
2017
Rooting for cassava: insights into photosynthesis and associated physiology as a route to improve yield potential.
De Souza AP, Massenburg LN, Jaiswal D, Cheng S, Shekar R, Long SP. Rooting for cassava: insights into photosynthesis and associated physiology as a route to improve yield potential. The New Phytologist 2017, 213: 50-65. PMID: 27778353, DOI: 10.1111/nph.14250.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements