2024
Abstract 146: Phosphodiesterase 10A Mediates Arterial Calcification Through A P38/MAPK-MMP3 Signaling
Jin Y, Xie Y, Berezowitz A, Davis S, Flores A, Wang X, Guzman R, Cai Y. Abstract 146: Phosphodiesterase 10A Mediates Arterial Calcification Through A P38/MAPK-MMP3 Signaling. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44: a146-a146. DOI: 10.1161/atvb.44.suppl_1.146.Peer-Reviewed Original ResearchVascular smooth muscle cellsChronic kidney diseasePeripheral arterial diseaseArtery calcificationInhibition of PDE10AMedial arterial calcificationVascular calcificationAssociated with increased cardiovascular morbidityCalcifying vascular smooth muscle cellsMatrix metallopeptidaseSmooth muscle cellsVSMCs in vitroCyclic nucleotides cAMPArteries in vivoMMP-3 upregulationCardiovascular morbidityCalcification in vivoArtery diseaseVon Kossa stainingKidney diseaseMuscle cellsRodent modelsVSMC calcificationInducible isoformCalcium assaySmooth muscle cell-specific matrix metalloproteinase 3 deletion reduces osteogenic transformation and medial artery calcification
Xie Y, Lin T, Jin Y, Berezowitz A, Wang X, Lu J, Cai Y, Guzman R. Smooth muscle cell-specific matrix metalloproteinase 3 deletion reduces osteogenic transformation and medial artery calcification. Cardiovascular Research 2024, 120: 658-670. PMID: 38454645, PMCID: PMC11074797, DOI: 10.1093/cvr/cvae035.Peer-Reviewed Original ResearchSmooth muscle cellsPeripheral arterial diseaseVascular smooth muscle cellsMedial calcificationMMP-3Osteogenic transformationRodent modelsAssociated with increased morbiditySmooth muscle cell calcificationChronic kidney diseaseEx vivo organ culture modelMMP-3 expressionOrgan culture modelMedial arterial calcificationTargeting MMP-3Matrix metalloproteinase 3MMP-3 proteinArtery calcificationArtery diseaseKidney diseaseVascular calcificationMuscle cellsTherapeutic strategiesCalcification mediumVitamin D3
2021
Recovery of limb perfusion and function after hindlimb ischemia is impaired by arterial calcification
Zettervall SL, Wang X, Monk S, Lin T, Cai Y, Guzman RJ. Recovery of limb perfusion and function after hindlimb ischemia is impaired by arterial calcification. Physiological Reports 2021, 9: e15008. PMID: 34405571, PMCID: PMC8371346, DOI: 10.14814/phy2.15008.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseMedial artery calcificationFemoral artery ligationVehicle-injected ratsMedial calcificationHindlimb ischemiaArtery calcificationLimb ischemiaArtery ligationFunctional recoveryArterial calcificationLaser Doppler perfusion imagingAcute limb ischemiaChronic kidney diseaseRecovery of perfusionVascular smooth muscle cellsSmooth muscle cellsLower extremity vesselsAmputation rateArtery diseaseArterial stiffnessClinical outcomesImpaired perfusionKidney diseaseLimb perfusion