Edward Vincent Faustino, MD, MHS
Professor of Pediatrics (Critical Care)Cards
About
Titles
Professor of Pediatrics (Critical Care)
Director of Trainee Research, Pediatrics; Chair, Pediatric Protocol Review Committee, Human Investigations Committee; Principal Investigator, Pathobiology, Epidemiology and Interventions against Thrombotic and Hemostatic Outcomes (PEITHO) Program, Pediatrics; Visiting Professor of Pediatrics (University of the Philippines College of Medicine)
Appointments
Pediatric Critical Care Medicine
ProfessorPrimary
Other Departments & Organizations
- Pediatric Critical Care Medicine
- Pediatric Critical Care Transport Program
- Pediatric Intensive Care Unit
- Pediatrics
- Yale Medicine
- YCCEH
Education & Training
- MHS
- Yale School of Medicine, Patient-Oriented Research (2014)
- Residency
- Yale-New Haven Hospital (2008)
- Fellow
- Yale University School of Medicine (2006)
- Residency
- Philippine General Hospital (2002)
- MD
- University of the Philippines, Medicine (1997)
Research
Overview
Dr. Faustino is a patient-oriented researcher who focuses on improving the outcomes of critically ill children. His research is focused on the prevention of venous thrombosis and its complications in children. He is the Principal Investigator of the Pathobiology, Epidemiology and Interventions against Thrombotic and Hemostatic Outcomes (PEITHO) Program. The goals of the PEITHO Program are (1) to conduct multi center observational studies that will inform the design and execution of interventional studies on venous thrombosis in children, (2) to conduct multi center randomized clinical trials on the prevention of venous thrombosis in children that will inform clinical practice, and (3) to leverage observational and interventional studies to understand the pathobiology of venous thrombosis in children.
Dr. Faustino is primarily investigating catheter-related thrombosis because the use of central venous catheters is the most common cause of venous thrombosis in children. He has conducted observational studies on the epidemiology of catheter-related thrombosis in critically ill children, completed surveys on thromboprophylaxis in pediatric intensive care units, identified potential biomarkers for catheter-related thrombosis and established collaborations with other researchers invested in the prevention of venous thrombosis. He recently completed a randomized clinical trial on early thromboprophylaxis against catheter-related thrombosis in critically ill children.
Dr. Faustino's ongoing studies include:
1. Age-dependent efficacy of enoxaparin against catheter-related thrombosis in critically ill children. The goal of these studies is to investigate the differential efficacy of enoxaparin between critically ill infants and older children against catheter-related thrombosis.
2. Role of platelets in catheter-related thrombosis in infants. The goal of these studies is to understand the role of platelets in the development of catheter-related thrombosis in infants.
3. Venous thrombosis in children at high risk of bleeding. The goal of these studies is to identify effective strategies against venous thrombosis in surgical or seriously injured children.
4. Venous thrombosis in critically ill adolescents. The goal of these studies is to identify the optimal strategy to prevent venous thrombosis in critically ill adolescents.
Medical Research Interests
Publications
2024
Demographic diversity in platelet function and response to antiplatelet therapy
Jain K, Tyagi T, Gu S, Faustino E, Hwa J. Demographic diversity in platelet function and response to antiplatelet therapy. Trends In Pharmacological Sciences 2024 PMID: 39672782, DOI: 10.1016/j.tips.2024.11.005.Peer-Reviewed Original ResearchResponse to antiplatelet therapyCardiovascular diseaseAntiplatelet therapyPlatelet biologyPathological platelet activationCardiovascular disease riskNon-genetic factorsPopulation-based differencesAntiplatelet strategiesPlatelet functionCardiovascular outcomesDiverse rolesPlatelet activationTherapeutic approachesTherapyPlateletBiologyProtocol for the Catheter-Related Early Thromboprophylaxis With Enoxaparin (CRETE) Studies.
Faustino E, Kandil S, Leroue M, Sochet A, Kong M, Cholette J, Nellis M, Pinto M, Chegondi M, Ramirez M, Schreiber H, Kerris E, Glau C, Kolmar A, Muisyo T, Sharathkumar A, Polikoff L, Silva C, Ehrlich L, Navarro O, Spinella P, Raffini L, Taylor S, McPartland T, Shabanova V. Protocol for the Catheter-Related Early Thromboprophylaxis With Enoxaparin (CRETE) Studies. Pediatric Critical Care Medicine 2024 PMID: 39560771, DOI: 10.1097/pcc.0000000000003648.Peer-Reviewed Original ResearchRandomized clinical trialsDose of enoxaparinCatheter-relatedEarly thromboprophylaxisHigher risk of clinically relevant bleedingRisk of clinically relevant bleedingProphylactic doses of enoxaparinTherapeutic dose of enoxaparinOlder childrenMarkers of thrombin generationClinically relevant bleedingEfficacy of prophylaxisDeep venous thrombosisRemoval of CVCsCritically ill childrenPlatelet-poor plasmaPost hoc analysisGestational ageInternational unitsInstitutional review boardRelevant bleedingProphylactic doseUsual careAge-dependent heterogeneityVenous thrombosisAnticoagulation Therapy for Venous Thromboembolism in the Pediatric Population: A Systematic Review and Meta-Analysis
Azzam M, Kawtharany H, Monagle P, Bercovitz R, Hamarsha Q, Alkhader A, Abou Zeid H, Mansour R, Patel P, Tabak C, Baghdadi S, Betensky M, Bhat R, Biss T, Branchford B, Brandao L, Chan A, Faustino E, Jaffray J, Jones S, Kerlin B, Kucine N, Kumar R, Male C, Pelland-Marcotte M, Raffini L, Raulji C, Sartain S, Takemoto C, Tarango C, Van Ommen H, Velez-Yanguas M, Vesely S, Wiernikowski J, Williams S, Wilson H, Woods G, Zia A, Mustafa R. Anticoagulation Therapy for Venous Thromboembolism in the Pediatric Population: A Systematic Review and Meta-Analysis. Blood 2024, 144: 1257-1257. DOI: 10.1182/blood-2024-212150.Peer-Reviewed Original ResearchRisk of biasCertainty of evidenceVenous thromboembolismPediatric patientsThrombus resolutionAll-cause mortalityThrombus recurrenceAC therapyAnticoagulant therapyAbsolute effectEvents of all-cause mortalityPediatric populationSystematic reviewNon-randomized Studies of InterventionsManagement of venous thromboembolismMeta-analysisStudies of interventionsConcerns related to riskNon-randomized observational studyNon-randomized studiesRecommendations AssessmentThrombus progressionBleeding eventsBleeding riskPortal hypertensionThrombolytic Therapy for Venous Thromboembolism in the Pediatric Population: A Systematic Review and Meta-Analysis
Kawtharany H, Azzam M, Monagle P, Bercovitz R, Alkhader A, Hamarsha Q, Zeid H, Mansour R, Tabak C, Patel P, Baghdadi S, Betensky M, Bhat R, Biss T, Branchford B, Brandao L, Chan A, Faustino E, Jaffray J, Jones S, Kerlin B, Kucine N, Kumar R, Male C, Pelland-Marcotte M, Raffini L, Raulji C, Sartain S, Takemoto C, Tarango C, Van Ommen H, Velez M, Vesely S, Wiernikowski J, Williams S, Wilson H, Woods G, Zia A, Mustafa R. Thrombolytic Therapy for Venous Thromboembolism in the Pediatric Population: A Systematic Review and Meta-Analysis. Blood 2024, 144: 2633. DOI: 10.1182/blood-2024-212166.Peer-Reviewed Original ResearchRate of thrombus resolutionAbsolute riskRisk of biasCertainty of evidenceMassive PEThrombolytic therapyPediatric patientsOutcome of thrombolysisAC groupPulmonary embolismSystematic reviewThrombus resolutionCovidence systematic review softwareRisk of thrombosis recurrenceThrombolysis groupMeta-analysisConcerns related to riskSystematic review softwareSubmassive pulmonary embolismChronic pulmonary hypertensionManagement of VTERestoring venous patencyRisk of progressionCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsHigh-Dimensional Single-Cell Mass Cytometry Demonstrates Differential Platelet Functional Phenotypes in Infants With Congenital Heart Disease
Gu S, Marcus B, Gu V, Varghese A, Hwa J, Faustino E. High-Dimensional Single-Cell Mass Cytometry Demonstrates Differential Platelet Functional Phenotypes in Infants With Congenital Heart Disease. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44: 2530-2539. PMID: 39171400, PMCID: PMC11602369, DOI: 10.1161/atvbaha.124.321131.Peer-Reviewed Original ResearchCongenital heart diseaseNon-CHD controlsSubpopulation of plateletsCytokine analysisAssociated with congenital heart diseaseSurface markersPlatelet activationHeart diseaseAssociated with hematological abnormalitiesChildren's Heart CenterPlasma cytokine analysisComplex heart defectsBlood of infantsThrombotic vascular complicationsIL (interleukin)-6Cell surface markersDecreased platelet activationMass cytometry approachPlatelet surface markersHypogranular plateletsHeart defectsBleeding eventsPlasma cytokinesPlatelet function phenotypesInflammatory markersBiomarker Assessment of a High-Risk, Data-Driven Pediatric Sepsis Phenotype Characterized by Persistent Hypoxemia, Encephalopathy, and Shock
Atreya M, Bennett T, Geva A, Faustino E, Rogerson C, Lutfi R, Cvijanovich N, Bigham M, Nowak J, Schwarz A, Baines T, Haileselassie B, Thomas N, Luo Y, Sanchez-Pinto L, Investigators F. Biomarker Assessment of a High-Risk, Data-Driven Pediatric Sepsis Phenotype Characterized by Persistent Hypoxemia, Encephalopathy, and Shock. Pediatric Critical Care Medicine 2024, 25: 512-517. PMID: 38465952, PMCID: PMC11153020, DOI: 10.1097/pcc.0000000000003499.Peer-Reviewed Original ResearchElectronic health recordsMultiple organ dysfunction syndromePediatric septic shock patientsSeptic shock patientsRisk strataElectronic health record dataSepsis phenotypesShock patientsPersistent multiple organ dysfunction syndromeAssociated with poor clinical outcomesDegree of systemic inflammationIncreased adjusted oddsHigh riskOrgan dysfunction syndromePoor clinical outcomesHealth recordsReceiver operating characteristic curveHigh-risk stratumArea under the receiver operating characteristic curveCritically ill patientsPredictive of deathSeverity of illnessAdjusted oddsIdentification of childrenOperating characteristics curveConsiderations for instituting pediatric pulmonary embolism response teams: A tool kit
Rajpurkar M, Rosovsky R, Williams S, Chan A, van Ommen C, Faustino E, White M, Parikh M, Sirachainan N, Biss T, Goldenberg N. Considerations for instituting pediatric pulmonary embolism response teams: A tool kit. Thrombosis Research 2024, 236: 97-107. PMID: 38417301, DOI: 10.1016/j.thromres.2024.02.019.Peer-Reviewed Original ResearchPulmonary Embolism Response TeamPediatric pulmonary embolismPediatric PETime to diagnosisIndividual physician's experiencePulmonary embolismDefinitive managementPE patientsResponse teamCritical care pathwayEpidemiological featuresCare pathwaysPhysician experiencePractice guidelinesPE outcomesDiagnosisCritical pathwaysPlatelet Mitochondrial Fusion and Function in Vascular Integrity
Tyagi T, Yarovinsky T, Faustino E, Hwa J. Platelet Mitochondrial Fusion and Function in Vascular Integrity. Circulation Research 2024, 134: 162-164. PMID: 38236952, PMCID: PMC10798220, DOI: 10.1161/circresaha.123.323867.Peer-Reviewed Original Research
2023
778: USE OF PERIPHERALLY INSERTED CENTRAL CATHETERS IN INFANTS: PICC STUDY
Chegondi M, Ness-Cochinwala M, Pinto M, Schreiber H, Polikoff L, Kerris E, Kothari H, Bloxham J, Berman-Sieger A, Mancuso B, Harder T, Korn S, Gillette C, Taillie E, Cholette J, Johnson R, Kaipa S, Faustino E. 778: USE OF PERIPHERALLY INSERTED CENTRAL CATHETERS IN INFANTS: PICC STUDY. Critical Care Medicine 2023, 52: s361-s361. DOI: 10.1097/01.ccm.0001001280.97724.e1.Peer-Reviewed Original Research813: BLOOD PRODUCT UTILIZATION IN INFANTS WITH PERIPHERALLY INSERTED CENTRAL CATHETERS
Ness-Cochinwala M, Chegondi M, Mancuso B, Berman-Sieger A, Pinto M, Schreiber H, Polikoff L, Kaipa S, Kerris E, Kothari H, Bloxham J, Harder T, Korn S, Gillette C, Taillie E, Cholette J, Johnson R, Faustino E. 813: BLOOD PRODUCT UTILIZATION IN INFANTS WITH PERIPHERALLY INSERTED CENTRAL CATHETERS. Critical Care Medicine 2023, 52: s379-s379. DOI: 10.1097/01.ccm.0001001420.46206.99.Peer-Reviewed Original Research
Clinical Trials
Current Trials
The RECOVER Long Covid Study at Yale
HIC ID2000033533RolePrincipal InvestigatorPrimary Completion Date04/01/2025Recruiting ParticipantsGenderBothAgeUp to 25 yearsTROPICS
HIC ID2000031760RolePrincipal InvestigatorPrimary Completion Date12/31/2027Recruiting ParticipantsARRC Trial
HIC ID2000031702RolePrincipal InvestigatorPrimary Completion Date12/31/2027Recruiting ParticipantsGenderBothAgeUp to 2 yearsCatheter-Related Early Thromboprophylaxis With Enoxaparin Studies (CRETE)
HIC ID2000030683RolePrincipal InvestigatorPrimary Completion Date04/30/2026Recruiting ParticipantsGenderBothAgeUp to 17 yearsPediatric Genomics Discovery Program (PGDP)
HIC ID1411014977RoleSub InvestigatorPrimary Completion Date12/31/2023Recruiting ParticipantsGenderBoth
Academic Achievements & Community Involvement
Clinical Care
Overview
Edward “Vince” Faustino, MD, MHS, is a pediatric intensivist, which means he takes care of critically ill children, most of whom improve dramatically in a matter of days or weeks.
“I treat children from a few days old up until their 20s. They tend to be very sick. A lot of them come into the hospital, and we need to support their organ function through breathing tubes, the heart-lung machine and other specialized ways,” Dr. Faustino says. “We manage them until they recover from whatever is causing the acute illness. Soon, they are up and about. They visit us a month later, and they are running around—I hardly recognize them. Kids bounce back quickly, which is great.”
Growing up in the Philippines, where his mother was a pediatrician, Dr. Faustino says he always knew he, too, wanted to be a pediatrician, and that he was drawn to the hospital setting.
Pediatric intensive care made sense to him because he gets to care for the “whole child,” while constantly being challenged with new cases. “There’s always something new to learn, which is exciting,” he says.
Dr. Faustino’s research explores the prevention of venous thromboembolism, a common, potentially lethal disorder that can affect hospitalized patients and cause long-term complications. He is also an associate professor of pediatric critical care at Yale School of Medicine.
Clinical Specialties
News & Links
News
- February 28, 2025
Find Yale Pediatrics at the 2025 Pediatric Academic Societies (PAS) Meeting
- December 12, 2024
Yale developmental science summer internship opens to undergrad applicants December 15
- June 10, 2024
Yale Child Study Center welcomes 2024 summer interns
- September 11, 2023
Leadership Announcement: Vince Faustino, MD, MHS Named Director of Trainee Research at Yale Pediatrics
Get In Touch
Contacts
Pediatric Critical Care Medicine
PO Box 208064
New Haven, CT 06520-8064
United States
Administrative Support
Locations
Hunter Building
Academic Office
15 York Street, Ste 305
New Haven, CT 06510
Patient Care Locations
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