2020
COVID-19, Renin-Angiotensin System and Endothelial Dysfunction
Amraei R, Rahimi N. COVID-19, Renin-Angiotensin System and Endothelial Dysfunction. Cells 2020, 9: 1652. PMID: 32660065, PMCID: PMC7407648, DOI: 10.3390/cells9071652.Peer-Reviewed Original ResearchConceptsRenin-angiotensin systemSARS-CoV-2Acute respiratory distress syndromeSARS-CoV-2 infectionEndothelial dysfunctionVascular damageCell adhesion moleculeSARS-CoV-2-induced acute respiratory distress syndromeCOVID-19Pre-existing endothelial dysfunctionSARS-CoV-2 entryRespiratory distress syndromeEndothelial cell injuryRole of ACE2Coronavirus disease 2019 (COVID-19) outbreakNovel coronavirus disease 2019 (COVID-19) outbreakCD209/DC-SIGNSARS-CoV-2 virusNew therapeutic strategiesDisease 2019 outbreakHuman vascular endotheliumGlobal public healthHost cellsAngiotensin fragmentsDistress syndrome
2019
The cell adhesion molecule IGPR-1 is activated by and regulates responses of endothelial cells to shear stress
Ho R, Tahboub R, Amraei R, Meyer R, Varongchayakul N, Grinstaff M, Rahimi N. The cell adhesion molecule IGPR-1 is activated by and regulates responses of endothelial cells to shear stress. Journal Of Biological Chemistry 2019, 294: 13671-13680. PMID: 31341021, PMCID: PMC6746441, DOI: 10.1074/jbc.ra119.008548.Peer-Reviewed Original ResearchConceptsIGPR-1Cell adhesion molecule IGPR-1Proline-rich receptor-1AKT Ser/ThrActin stress fiber assemblySer/ThrCell-cell junctionsStress fiber assemblyCell-cell contactEndothelial cellsActin fiber assemblyEndothelial cell remodelingFiber assemblyCell mechanosensingBlood flow-induced shear stressCell remodelingCellular responsesMechanical signalsVascular endothelial cellsImportant playersFlow-induced shear stressPhosphorylationCellsReceptor 1Cell borders