2023
Ultrasensitive quantification of HIV-1 cell-to-cell transmission in primary human CD4+ T cells measures viral sensitivity to broadly neutralizing antibodies
Mazurov D, Herschhorn A. Ultrasensitive quantification of HIV-1 cell-to-cell transmission in primary human CD4+ T cells measures viral sensitivity to broadly neutralizing antibodies. MBio 2023, 15: e02428-23. PMID: 38063394, PMCID: PMC10790777, DOI: 10.1128/mbio.02428-23.Peer-Reviewed Original ResearchConceptsHIV-1 cell-to-cell transmissionCell-to-cell transmissionHIV-1Neutralizing antibodiesHIV-1 escapeHIV-1 transmissionHIV-1 resistanceHuman T cellsT cellsClinical trialsMode of transmissionViral sensitivityUltrasensitive assayEvaluation of pre-existingAntibodiesAssayCellsPre-existingRetrovirusesTrials
2011
Role of O-Glycosylation and Expression of CD43 and CD45 on the Surfaces of Effector T Cells in Human T Cell Leukemia Virus Type 1 Cell-to-Cell Infection
Mazurov D, Ilinskaya A, Heidecker G, Filatov A. Role of O-Glycosylation and Expression of CD43 and CD45 on the Surfaces of Effector T Cells in Human T Cell Leukemia Virus Type 1 Cell-to-Cell Infection. Journal Of Virology 2011, 86: 2447-2458. PMID: 22171268, PMCID: PMC3302266, DOI: 10.1128/jvi.06993-11.Peer-Reviewed Original ResearchConceptsJurkat cellsVirus type 1Expression of CD43Short hairpin RNAT cellsHTLV-1O-glycosylationHIV-1O-glycan elongationType 1Human immune deficiency virus type 1Effector T cellsHIV-1 infectionHuman T-cell leukemia virus type 1Cell-to-cell infectionSurface of T cellsCell-cell contactJurkat T cellsHTLV-1 infectionHTLV-1 proteinsHTLV-1 particlesCell surface antigensChaperone CosmcInfectious structuresCosmc gene
2005
HTLV-1 Gag protein associates with CD82 tetraspanin microdomains at the plasma membrane
Mazurov D, Heidecker G, Derse D. HTLV-1 Gag protein associates with CD82 tetraspanin microdomains at the plasma membrane. Virology 2005, 346: 194-204. PMID: 16325219, DOI: 10.1016/j.virol.2005.10.033.Peer-Reviewed Original ResearchConceptsHTLV-1 GagHTLV-1T cellsPresence of bacterial superantigensPlasma membraneGag proteinHIV-1 GagMembrane of T cellsAssociation of GagViral envelope glycoproteinsPlasma membrane of T cellsRaji B cellsCell extractsBacterial superantigensAntibody-mediated cross-linkingB cellsHIV-1Confocal image analysisEnvelope glycoproteinTetraspanin-enriched microdomainsJurkat T cellsImmunofluorescence stainingImmune synapseGag multimerizationIntercellular adhesion