PP7.7 – 00092 Single-Nucleus Multiomic Sequencing Uncovers Differential Chromatin Accessibility and Gene Regulation in Cerebrospinal Fluid Cells of PWH
Lu C, Orlinick B, Das B, Filippidis P, Mehta S, Spudich S, Pang A, Kluger Y, Corley M, Farhadian S. PP7.7 – 00092 Single-Nucleus Multiomic Sequencing Uncovers Differential Chromatin Accessibility and Gene Regulation in Cerebrospinal Fluid Cells of PWH. Journal Of Virus Eradication 2024, 10: 87-88. DOI: 10.1016/j.jve.2024.100530.Peer-Reviewed Original ResearchDifferential chromatin accessibilityChromatin accessibilityGene regulationSingle-nucleusCerebrospinal fluid cellsGenesPrevalence of detectable HIV-DNA and HIV-RNA in cerebrospinal fluid of youth with perinatal HIV and impaired cognition on antiretroviral therapy
Wagner T, Tierney C, Huang S, Nichols S, Malee K, Montañez N, Coletti A, Spiegel H, Krotje C, Bone F, Wilkins M, Abuogi L, Purswani M, Bearden A, Wiznia A, Agwu A, Chadwick E, Richman D, Gandhi M, Mehta P, Macatangay B, Spector S, Spudich S, Persaud D, Chahroudi A, Team F. Prevalence of detectable HIV-DNA and HIV-RNA in cerebrospinal fluid of youth with perinatal HIV and impaired cognition on antiretroviral therapy. AIDS 2024, 38: 1494-1504. PMID: 38814693, PMCID: PMC11239098, DOI: 10.1097/qad.0000000000003937.Peer-Reviewed Original ResearchCell-free HIV RNAAntiretroviral therapyHIV DNACentral nervous systemDetect HIV DNACerebrospinal fluidHIV RNAPerinatal HIVLong-term virologic suppressionFluid cognition composite scoresSuppressive antiretroviral therapyCerebrospinal fluid cellsHair antiretroviral concentrationsHIV DNA detectionQuantify HIVVirologic suppressionAntiretroviral concentrationsCD4 countCerebrospinal fluid collectionHIV infectionHIV GagPol DNANeurocognitive impairmentCognitive impairmentHIV