2012
Increased Hyperoxia-Induced Lung Injury in Nitric Oxide Synthase 2 Null Mice Is Mediated via Angiopoietin 2
Bhandari V, Choo-Wing R, Harijith A, Sun H, Syed MA, Homer RJ, Elias JA. Increased Hyperoxia-Induced Lung Injury in Nitric Oxide Synthase 2 Null Mice Is Mediated via Angiopoietin 2. American Journal Of Respiratory Cell And Molecular Biology 2012, 46: 668-676. PMID: 22227562, PMCID: PMC3359903, DOI: 10.1165/rcmb.2011-0074oc.Peer-Reviewed Original ResearchConceptsHyperoxic acute lung injuryNOS/nitric oxideNitric oxideLung injuryAngiopoietin-2Pathogenesis of HALIAlveolar-capillary protein leakAcute respiratory distress syndromeHyperoxia-Induced Lung InjuryAcute lung injuryRespiratory distress syndromeImportant protective roleCell deathBronchopulmonary dysplasiaDistress syndromeSupplemental oxygenNb miceProtein leakTissue injuryProtective roleNewbornsNull micePremature deathAdult controlsAng2
2005
Regulation of lung injury and repair by Toll-like receptors and hyaluronan
Jiang D, Liang J, Fan J, Yu S, Chen S, Luo Y, Prestwich GD, Mascarenhas MM, Garg HG, Quinn DA, Homer RJ, Goldstein DR, Bucala R, Lee PJ, Medzhitov R, Noble PW. Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nature Medicine 2005, 11: 1173-1179. PMID: 16244651, DOI: 10.1038/nm1315.Peer-Reviewed Original ResearchConceptsAcute lung injuryLung injuryToll-like receptorsInflammatory responseTLR2-dependent mannerSera of individualsCell-specific overexpressionEpithelial cell apoptosisEpithelial cell integrityHyaluronan degradation productsChemokine productionInflammatory cellsTissue injuryExtracellular matrix glycosaminoglycan hyaluronanTransepithelial migrationInjuryCell surface hyaluronanHyaluronan fragmentsCell apoptosisBasal activationClearance resultsInflammationGlycosaminoglycan hyaluronanReceptorsHyaluronanAirway Remodeling in Asthma: Therapeutic Implications of Mechanisms
Homer RJ, Elias JA. Airway Remodeling in Asthma: Therapeutic Implications of Mechanisms. Physiology 2005, 20: 28-35. PMID: 15653837, DOI: 10.1152/physiol.00035.2004.Peer-Reviewed Original Research