2020
Thymus-derived B cell clones persist in the circulation after thymectomy in myasthenia gravis
Jiang R, Hoehn KB, Lee CS, Pham MC, Homer RJ, Detterbeck FC, Aban I, Jacobson L, Vincent A, Nowak RJ, Kaminski HJ, Kleinstein SH, O'Connor KC. Thymus-derived B cell clones persist in the circulation after thymectomy in myasthenia gravis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 30649-30660. PMID: 33199596, PMCID: PMC7720237, DOI: 10.1073/pnas.2007206117.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAutoantibodiesBiomarkersB-LymphocytesClonal EvolutionClonal Selection, Antigen-MediatedDisease SusceptibilityFemaleHumansLymphocyte CountMaleMiddle AgedModels, BiologicalMyasthenia GravisRadioimmunoassayReceptors, CholinergicThymectomyThymus GlandV(D)J RecombinationYoung AdultConceptsB cell clonesMyasthenia gravisB cell repertoireB cellsCell clonesPlasma cellsCell repertoireAdditional immunosuppressive treatmentDiminished clinical responseThymic lymphofollicular hyperplasiaComplete stable remissionMajority of patientsAntigen-experienced B cellsRandomized clinical trialsClinical symptom measuresAChR autoantibodiesImmunosuppressive treatmentSteroid doseAutoantibody titersMG thymusClinical responseStable remissionClinical scoresAutoimmune diseasesClinical trials
1998
ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES AS MARKERS FOR SYSTEMIC AUTOIMMUNE DISEASE
Homer R. ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES AS MARKERS FOR SYSTEMIC AUTOIMMUNE DISEASE. Clinics In Chest Medicine 1998, 19: 627-639. PMID: 9917957, DOI: 10.1016/s0272-5231(05)70107-6.Peer-Reviewed Original ResearchConceptsAntineutrophil cytoplasmic antibodyCytoplasmic antibodiesSpectrum of diseaseAntigen-specific assaysANCA testingSystemic vasculitisChest PhysiciansAutoimmune diseasesPretest probabilitySpecific antigenClinical useDiseaseSpecific testingSpecific assayAntibodiesAccurate assessmentVasculitisAntigenPhysiciansSignificant advances