2024
Chronicling menstrual cycle patterns across the reproductive lifespan with real-world data
Cunningham A, Pal L, Wickham A, Prentice C, Goddard F, Klepchukova A, Zhaunova L. Chronicling menstrual cycle patterns across the reproductive lifespan with real-world data. Scientific Reports 2024, 14: 10172. PMID: 38702411, PMCID: PMC11068910, DOI: 10.1038/s41598-024-60373-3.Peer-Reviewed Original Research
2017
Ovarian Sertoli-Leydig cell tumors: a single institution experience and review of the literature.
Gressel G, Buza N, Pal L. Ovarian Sertoli-Leydig cell tumors: a single institution experience and review of the literature. European Journal Of Gynaecological Oncology 2017, 38: 214-220. PMID: 29953783.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsChemotherapy, AdjuvantDisease-Free SurvivalFemaleHumansHyperandrogenismHysterectomyMiddle AgedNeoadjuvant TherapyNeoplasm GradingOvarian NeoplasmsOvariectomyPostmenopauseRetrospective StudiesSalpingectomySertoli-Leydig Cell TumorConceptsSertoli-Leydig cell tumorOvarian Sertoli-Leydig cell tumorPresent patient populationDisease-free survivalSingle institution experienceTertiary care institutionTime of diagnosisOnset of menopauseRisk of recurrenceSeries of casesAdjuvant chemotherapyMedian followPostmenopausal bleedingPostmenopausal patientsMedian ageMedian intervalClinical presentationDefinitive managementPathological findingsRetrospective reviewInstitution experiencePatient populationTreatment modalitiesCell tumorsTumor grade
2008
Characterizing the reproductive hormone milieu in infertile women with diminished ovarian reserve
Pal L, Zhang K, Zeitlian G, Santoro N. Characterizing the reproductive hormone milieu in infertile women with diminished ovarian reserve. Fertility And Sterility 2008, 93: 1074-1079. PMID: 19100532, DOI: 10.1016/j.fertnstert.2008.10.069.Peer-Reviewed Original ResearchConceptsDiminished ovarian reserveReproductive hormone profilesOvarian reserveInfertile womenUrinary excretionMenstrual cycleHealthy controlsHormone profilesAge-comparable healthy controlsUrinary FSH levelsProspective observational studyEarly follicular phaseEntire menstrual cycleAge-comparable controlsMetabolites of estrogenFSH levelsHormone milieuInfertility practiceMenopause transitionUrine voidsFollicular phaseEstrone conjugatesFSH surgeObservational studyMAIN OUTCOMEDiminished ovarian reserve in a woman with a balanced 13;21 translocation
Kummer N, Martin JR, Pal L. Diminished ovarian reserve in a woman with a balanced 13;21 translocation. Fertility And Sterility 2008, 91: 931.e3-931.e5. PMID: 18829026, DOI: 10.1016/j.fertnstert.2008.07.1726.Peer-Reviewed Original ResearchConceptsOvarian reservePrimary infertilityDecreased ovarian reserveUniversity Teaching HospitalLaboratory evaluationBalanced autosomal translocationEndocrinologic evaluationConcomitant findingsEarly menopauseInfertility practiceUnknown etiologyCase reportCaucasian womenTeaching hospitalMAIN OUTCOMEFamilial historyReproductive endocrinologySemen analysisBalanced translocationInfertilityPossible roleDiagnosisWomenAutosomal translocationsKaryotype analysisLess is more: increased gonadotropin use for ovarian stimulation adversely influences clinical pregnancy and live birth after in vitro fertilization
Pal L, Jindal S, Witt BR, Santoro N. Less is more: increased gonadotropin use for ovarian stimulation adversely influences clinical pregnancy and live birth after in vitro fertilization. Fertility And Sterility 2008, 89: 1694-1701. PMID: 18440515, PMCID: PMC2601677, DOI: 10.1016/j.fertnstert.2007.05.055.Peer-Reviewed Original ResearchConceptsNondonor IVF cyclesClinical pregnancyCycle cancellationLive birthsGonadotropin useIVF cyclesSpontaneous miscarriageOvarian reserve statusOvarian hyperstimulation resultsHigh gonadotropinsOvarian stimulationFertilization cyclesIVF outcomesOocyte yieldWorse prognosisRetrospective studyIVF centerImproved outcomesAggressive approachMAIN OUTCOMEPregnancyIVFHigher likelihoodBirthOutcomes
2004
Postthaw blastomere survival is predictive of the success of frozen–Thawed embryo transfer cycles
Pal L, Kovacs P, Witt B, Jindal S, Santoro N, Barad D. Postthaw blastomere survival is predictive of the success of frozen–Thawed embryo transfer cycles. Fertility And Sterility 2004, 82: 821-826. PMID: 15482754, DOI: 10.1016/j.fertnstert.2004.02.136.Peer-Reviewed Original ResearchConceptsEmbryo transfer cyclesFET cyclesBlastomere survivalImplantation rateTransfer cyclesFrozen-thawed embryo transfer cyclesClinical pregnancy rateTertiary care facilitySerum P levelsClinical pregnancyHCG administrationInfertile womenRetrospective studyInverse associationIVF unitPregnancy rateMAIN OUTCOMECare facilitiesPregnancySurvivalOutcomesEmbryo survivalLower survivalHigher survivalAdministration
2003
Omental trophoblastic implants and hemoperitoneum after laparoscopic salpingostomy for ectopic pregnancy. A case report.
Pal L, Parkash V, Rutherford TJ. Omental trophoblastic implants and hemoperitoneum after laparoscopic salpingostomy for ectopic pregnancy. A case report. The Journal Of Reproductive Medicine 2003, 48: 57-9. PMID: 12611098.Peer-Reviewed Original ResearchConceptsEctopic pregnancyLaparoscopic salpingostomyTrophoblastic implantsIntraabdominal bleedingTrocar placementCommon gynecologic emergencyPositive intraabdominal pressureRecurrent ectopic pregnancySerum beta-hCGUneventful postoperative courseAnterior abdominal wallPostoperative day 21Infracolic omentectomyActive bleedingExploratory laparotomyLaparoscopic managementTubal rupturePostoperative coursePostoperative periodPostoperative surveillanceBeta-hCGTrendelenburg positionSurgical interventionCase reportGynecologic emergencies
1999
Effect of a baseline ovarian cyst on the outcome of in vitro fertilization–embryo transfer
Segal S, Shifren J, Isaacson K, Leykin L, Chang Y, Pal L, Toth T. Effect of a baseline ovarian cyst on the outcome of in vitro fertilization–embryo transfer. Fertility And Sterility 1999, 71: 274-277. PMID: 9988397, DOI: 10.1016/s0015-0282(98)00449-x.Peer-Reviewed Original ResearchConceptsBaseline ovarian cystsOvarian cystsHCG administrationE2 levelsPregnancy rateDay 3Cycle day 3Fertilization-embryo transferOutcome of IVFNumber of folliclesNumber of oocytesNumber of embryosBaseline cystOvarian hyperstimulationIVF-ETPoor outcomeRetrospective studyUltrasound examinationMAIN OUTCOMEAcademic centersFertilization unitCystsPatientsMature oocytesOutcomes
1998
Malignancy may adversely influence the quality and behaviour of oocytes.
Pal L, Leykin L, Schifren J, Isaacson K, Chang Y, Nikruil N, Chen Z, Toth T. Malignancy may adversely influence the quality and behaviour of oocytes. Human Reproduction 1998, 13: 1837-1840. PMID: 9740435, DOI: 10.1093/humrep/13.7.1837.Peer-Reviewed Original ResearchConceptsMalignant diseaseMalignant disordersAge-matched patientsCell of originTubal infertilityIVF cyclesOvarian stimulationDefinitive treatmentCase seriesCertain malignanciesNeoplastic processPatientsComparable total numberMature oocytesMalignancyFertilization rateDiseasePotential fertilityApparent adverse influenceOocytesPoor qualityDisordersTotal numberAdverse influenceInfertilityImpact of Varying Stages of Endometriosis on the Outcome of In Vitro Fertilization–Embryo Transfer
Pal L, Shifren J, Isaacson K, Chang Y, Leykin L, Toth T. Impact of Varying Stages of Endometriosis on the Outcome of In Vitro Fertilization–Embryo Transfer. Journal Of Assisted Reproduction And Genetics 1998, 15: 27-31. PMID: 9493063, PMCID: PMC3468198, DOI: 10.1023/a:1022574221115.Peer-Reviewed Original ResearchConceptsSeverity of endometriosisMale factor infertilityIVF cyclesIVF-ETGroup BGroup AIVF-embryo transfer cyclesVitro Fertilization-Embryo TransferAmerican Fertility Society classificationGonadotropin-releasing hormone agonistAcademic IVF programDay 3 follicleHuman menopausal gonadotropinCycles of IVFFertilization-embryo transferIU/LCombination of FSHOocytes of patientsSeverity of diseaseQuality of oocytesImpact of severityMenopausal gonadotropinOvarian hyperstimulationAdvanced diseaseClinical pregnancy
1997
Outcome of IVF in DES-Exposed Daughters: Experience in the 90s
Pal L, Shifren J, Isaacson K, Chang Y, Marean M, Leykin L, Toth T. Outcome of IVF in DES-Exposed Daughters: Experience in the 90s. Journal Of Assisted Reproduction And Genetics 1997, 14: 513-517. PMID: 9401869, PMCID: PMC3454843, DOI: 10.1023/a:1021175326230.Peer-Reviewed Original ResearchConceptsMassachusetts General HospitalOngoing pregnancy rateOutcome of IVFIVF cyclesInfertile womenUtero exposurePregnancy rateAcademic IVF programDay 3 levelsOutcome of ARTSelf-reported historyQuality of embryosOvarian hyperstimulationUtero DiethylstilbestrolControl patientsIdiopathic infertilitySerum estradiolImplantation rateInfertile patientsIVF programGeneral HospitalIVF unitEmbryo transferPatientsLow implantationBrenner tumor in 46,XY gonadal dysgenesis.
Pal L, Taylor A, Kirby R, Isaacson K. Brenner tumor in 46,XY gonadal dysgenesis. Obstetrics And Gynecology 1997, 90: 707-8. PMID: 11770612, DOI: 10.1016/s0029-7844(97)00364-5.Peer-Reviewed Original ResearchComparison of office hysteroscopy, transvaginal ultrasonography and endometrial biopsy in evaluation of abnormal uterine bleeding.
Pal L, Lapensee L, Toth T, Isaacson K. Comparison of office hysteroscopy, transvaginal ultrasonography and endometrial biopsy in evaluation of abnormal uterine bleeding. JSLS Journal Of The Society Of Laparoscopic & Robotic Surgeons 1997, 1: 125-30. PMID: 9876659, PMCID: PMC3021277.Peer-Reviewed Original ResearchConceptsAbnormal uterine bleedingEndometrial biopsyIntrauterine lesionsUterine bleedingFocal intrauterine lesionsAbnormal bleedingOffice hysteroscopyTransvaginal ultrasonographyTransvaginal ultrasoundNormal endometrial biopsyTransvaginal ultrasound scanHormone replacement therapyProspective observational studyIncidence of lesionsNegative predictive valueEnlarged uterusEvaluatory approachRegular bleedingBleeding patternsPostmenopausal groupOutpatient settingReplacement therapyUltrasound scanObservational studyBleeding