2020
Minimally Invasive Image-Guided Ablation, Osteoplasty, Reinforcement, and Internal Fixation (AORIF) for Osteolytic Lesions in the Pelvis and Periarticular Regions of Weight-Bearing Bones
Lee FY, Latich I, Toombs C, Mungur A, Conway D, Alder K, Ibe I, Lindskog D, Friedlaender G. Minimally Invasive Image-Guided Ablation, Osteoplasty, Reinforcement, and Internal Fixation (AORIF) for Osteolytic Lesions in the Pelvis and Periarticular Regions of Weight-Bearing Bones. Journal Of Vascular And Interventional Radiology 2020, 31: 649-658.e1. PMID: 32139256, DOI: 10.1016/j.jvir.2019.11.029.Peer-Reviewed Original ResearchMeSH KeywordsAblation TechniquesAdultAgedAged, 80 and overBone CementsBone NeoplasmsBone RemodelingBone ScrewsCalcaneusCementoplastyFemaleFemoral NeoplasmsFemurFracture Fixation, InternalHumansMaleMiddle AgedOsteolysisPelvic BonesPostoperative ComplicationsProspective StudiesRecovery of FunctionTibiaTime FactorsTreatment OutcomeWeight-BearingConceptsOsteolytic lesionsInternal fixationVisual analog scale pain scoreMusculoskeletal Tumor Society scoreProspective clinical cohort studyFunctional ambulation scoreOsteolytic skeletal lesionsPainful osteolytic lesionsScale pain scoresClinical cohort studyInvasive percutaneous approachWeight-bearing boneInternal fixation screwsBalloon osteoplastyPain scoresCohort studyProphylactic stabilizationSevere painSociety ScoreConsecutive patientsSurgical treatmentEarly outcomesTreatment optionsPercutaneous approachFunctional improvement
2019
Rotational Tibio-Pelvic Constrained Hip Arthroplasty: A Surgical Technique: A Case Report.
Cahill SV, Yu KE, Dussik CM, Lee FY. Rotational Tibio-Pelvic Constrained Hip Arthroplasty: A Surgical Technique: A Case Report. JBJS Case Connector 2019, 9: e0404. PMID: 31703012, DOI: 10.2106/jbjs.cc.18.00404.Peer-Reviewed Original ResearchConceptsSoft tissue infectionsVan Nes rotationplastyExtensive debridementChronic boneHip disarticulationTissue infectionsFemur resectionDebridement proceduresRecurrent infectionsCase reportRight thighEpithelioid sarcomaSurgical techniqueHip arthroplastyIncurable infectionProsthetic hipInfectionRotationplastyResectionMultiple revisionsProsthetic devicesDebridementPatientsSarcomaArthroplasty
2015
Activation of Protein Kinase A in Mature Osteoblasts Promotes a Major Bone Anabolic Response
Tascau L, Gardner T, Anan H, Yongpravat C, Cardozo CP, Bauman WA, Lee FY, Oh DS, Tawfeek HA. Activation of Protein Kinase A in Mature Osteoblasts Promotes a Major Bone Anabolic Response. Endocrinology 2015, 157: 112-126. PMID: 26488807, DOI: 10.1210/en.2015-1614.Peer-Reviewed Original ResearchMeSH KeywordsAMP-Activated Protein KinasesAnimalsBone DensityCells, CulturedEnergy MetabolismEnzyme ActivationFemaleFemurLumbar VertebraeMaleMice, Inbred C57BLMice, TransgenicOsteoblastsOsteocytesOsteogenesisPoint MutationPromoter Regions, GeneticSex CharacteristicsUp-RegulationX-Ray MicrotomographyConceptsBone anabolic responseOb miceMature osteoblastsPKA activationHigher basal PKA activityControl miceAnabolic responseProtein kinase ASerum bone turnover markersBone volume/total volumeBone turnover markersBasal PKA activityFemur cortical thicknessTotal tissue areaActive PKAKinase AConstitutive activationPKA activityTurnover markersBone lossAnabolic drugsStructure model indexOsteoclast numberFemale miceBone mass
2013
Physiologic load-bearing characteristics of autografts, allografts, and polymer-based scaffolds in a critical sized segmental defect of long bone: an experimental study
Amorosa L, Lee C, Aydemir, Nizami S, Hsu A, Patel N, Gardner T, Navalgund A, Kim DG, Park S, Mao J, Lee F. Physiologic load-bearing characteristics of autografts, allografts, and polymer-based scaffolds in a critical sized segmental defect of long bone: an experimental study. International Journal Of Nanomedicine 2013, Volume 8: 1637-1643. PMID: 23637532, PMCID: PMC3639117, DOI: 10.2147/ijn.s42855.Peer-Reviewed Original ResearchConceptsAddition of hMSCsPolymer-based scaffoldsLoad-bearing characteristicsPhysiologic cyclic loadingPhase angleCritical-sized segmental defectsScaffold alone groupViscous stiffnessCyclic loadingMechanical propertiesFemoral defect modelSized segmental defectsRat femoral defect modelHuman mesenchymal stem cellsMechanical simulationsScaffold groupDifferent biomechanical characteristicsEnhanced bone formationHigh phase anglesDefect modelBiomechanical characteristicsExperimental studyHost boneStiffnessDefect repair
2009
Zoledronate reduces unwanted bone resorption in intercalary bone allografts
Seo SW, Cho SK, Storer SK, Lee FY. Zoledronate reduces unwanted bone resorption in intercalary bone allografts. International Orthopaedics 2009, 34: 599-603. PMID: 19343345, PMCID: PMC2903128, DOI: 10.1007/s00264-009-0748-7.Peer-Reviewed Original ResearchConceptsAllograft resorptionIntercalary allograftsBone resorptionBone allograftControl groupZoledronate solutionIntercalary bone allograftsBone formationBone mineral densitySynthetic pyrophosphate analoguesHigh-dose bisphosphonatesPharmacological modificationGraft incorporationMineral densityBone densityAllograftsIdeal doseResorptionAnimal trialsHistological analysisBisphosphonatesSegmental defectsPyrophosphate analogsExperimental groupRat femur
2008
Enhancement of Periprosthetic Bone Quality with Topical Hydroxyapatite-Bisphosphonate Composite
Suratwala SJ, Cho SK, van Raalte JJ, Park SH, Seo SW, Chang SS, Gardner TR, Lee FY. Enhancement of Periprosthetic Bone Quality with Topical Hydroxyapatite-Bisphosphonate Composite. Journal Of Bone And Joint Surgery 2008, 90: 2189-2196. PMID: 18829917, PMCID: PMC2657477, DOI: 10.2106/jbjs.g.00409.Peer-Reviewed Original ResearchConceptsPeriprosthetic bone qualityPeriprosthetic bone massSix-month groupBone qualitySix weeksOsseous integrationBone massParticle-induced periprosthetic osteolysisImplant looseningDual X-ray absorptiometryInflammatory bone lossX-ray absorptiometryMean bone areaUltra-high molecular weight polyethyleneBone lossSix-week groupUltra-high molecular weight polyethylene particlesIntramedullary nailFemoral canalMolecular weight polyethyleneControl groupPeriprosthetic osteolysisBone areaPeak pullout forceIntramedullary implants
2001
Magnetic resonance imaging depiction of tight iliotibial band in melorheostosis associated with severe external rotation deformity, limb shortening and patellar dislocation in planning surgical correction
Osgood GM, Lee F, Parisien MV, Ruzal-Shapiro C. Magnetic resonance imaging depiction of tight iliotibial band in melorheostosis associated with severe external rotation deformity, limb shortening and patellar dislocation in planning surgical correction. Skeletal Radiology 2001, 31: 49-52. PMID: 11807595, DOI: 10.1007/s00256-001-0443-2.Peer-Reviewed Original ResearchConceptsIliotibial bandPatellar dislocationSurgical correctionExternal rotation deformityExternal rotational deformityIliotibial band tightnessTight iliotibial bandDistal femoral epiphysisMagnetic resonance imagingMagnetic resonance imaging depictionFemoral shorteningMR signal changesRotation deformityGenu valgumSkeletal surveyLimb shorteningLower extremitiesRotational deformityFemoral shaftFemoral epiphysisFemoral headResonance imagingPhalangeal bonesSubcutaneous layerDeformity
1998
Pathologic supracondylar fracture due to osteolytic pseudotumor of knee following cementless total knee replacement
Benevenia J, Lee F, Buechel F, Parsons J. Pathologic supracondylar fracture due to osteolytic pseudotumor of knee following cementless total knee replacement. Journal Of Biomedical Materials Research 1998, 43: 473-477. PMID: 9855207, DOI: 10.1002/(sici)1097-4636(199824)43:4<473::aid-jbm16>3.0.co;2-9.Peer-Reviewed Original ResearchConceptsWear debrisForeign body reactionPathologic fractureSupracondylar fracturesReplacement arthroplastyDebris of polyethyleneTotal knee replacement arthroplastyCementless total knee replacementAggressive granulomatous lesionsBody reactionKnee replacement arthroplastyJoint replacement arthroplastySoft tissue massTotal knee replacementAseptic prosthetic looseningTotal knee prosthesisMassive osteolysisGranulomatous lesionsTumorlike lesionsKnee replacementProsthetic looseningTissue massFemoral componentLesionsKnee prosthesis