2019
Bone Quality and Fracture-Healing in Type-1 and Type-2 Diabetes Mellitus.
Henderson S, Ibe I, Cahill S, Chung YH, Lee FY. Bone Quality and Fracture-Healing in Type-1 and Type-2 Diabetes Mellitus. Journal Of Bone And Joint Surgery 2019, 101: 1399-1410. PMID: 31393433, DOI: 10.2106/jbjs.18.01297.Peer-Reviewed Original ResearchConceptsType 2 diabetesPerioperative complicationsDiabetic patientsGlycemic controlBone healthType 1Type 2 diabetes mellitusNormal bone mineral densityPerioperative glycemic controlNon-diabetic patientsEarly bone lossSurgical site infectionAppropriate glycemic controlUnion of fractureRisk of fractureBone mineral densityType 1 diabetesAntiresorptive therapyOperative interventionDiabetes mellitusSclerostin antibodySite infectionMedical managementParathyroid hormonePostoperative managementBisphosphonate-loaded Bone Cement as a Local Adjuvant Therapy for Giant Cell Tumor of Bone
Greenberg DD, Lee FY. Bisphosphonate-loaded Bone Cement as a Local Adjuvant Therapy for Giant Cell Tumor of Bone. American Journal Of Clinical Oncology 2019, 42: 231-237. PMID: 30811352, DOI: 10.1097/coc.0000000000000504.Peer-Reviewed Original ResearchConceptsGiant cell tumorAdjuvant therapyLocal adjuvant therapySystemic side effectsAvascular necrosisCell tumorsSide effectsMusculoskeletal Tumor Society scoreOsteoclast-like giant cellsAggressive bone resorptionTherapeutic Level IVHigh-speed burringLocal recurrence rateAtypical femur fracturesLevel of evidenceTraditional adjuvant therapyBone cementAtypical fracturesSystemic bisphosphonatesPulmonary metastasesSociety ScoreCurettage proceduresRecurrence rateFemur fracturesPolymethylmethacrylate bone cementPharmacologic and Radiation Therapies for Cancer-Induced Bone Loss.
Henderson SE, Dussik C, Brand J, Ibe IK, Lee FY. Pharmacologic and Radiation Therapies for Cancer-Induced Bone Loss. Instructional Course Lectures 2019, 68: 557-566. PMID: 32032067.Peer-Reviewed Original ResearchMeSH KeywordsDrug TherapyFractures, SpontaneousHumansOrthopedic ProceduresPrognosisQuality of LifeRadiotherapyMetastatic Cancers to Bone: An Overview and Cancer-Induced Bone Loss.
Ibe IK, Sahlstrom A, White A, Henderson SE, Lee FY. Metastatic Cancers to Bone: An Overview and Cancer-Induced Bone Loss. Instructional Course Lectures 2019, 68: 547-556. PMID: 32032068.Peer-Reviewed Original ResearchConceptsCancer-induced bone lossBone lossBone metastasesMetastatic bone diseaseCancer cellsDegree of osteolysisNormal bone homeostasisBenefit of patientsOsteolytic metastasesSkeletal metastasesPatient functionSurgical stabilizationWorse prognosisLocal bone massBone massMetastatic cancerBone diseaseRadiation therapyTherapeutic modalitiesBone homeostasisImmune systemOverall outcomeMetastasisBone remodelingPatients
1999
Chondrosarcoma of bone: an assessment of outcome.
Lee FY, Mankin HJ, Fondren G, Gebhardt MC, Springfield DS, Rosenberg AE, Jennings LC. Chondrosarcoma of bone: an assessment of outcome. Journal Of Bone And Joint Surgery 1999, 81: 326-38. PMID: 10199270, DOI: 10.2106/00004623-199903000-00004.Peer-Reviewed Original ResearchConceptsGrade 3 lesionsIntralesional resectionLocal recurrenceHistological gradePostoperative adjuvant radiationLimb-sparing proceduresPredictor of metastasisGroup of patientsHigh-grade lesionsLow-grade tumorsPredictors of outcomeHigh-grade tumorsAssessment of outcomesAdjuvant radiationPathological fracturesRecurrent diseasePulmonary metastasesDistant metastasisAdjunctive chemotherapyMarginal resectionMean ageMean durationPelvic locationPrevalent siteGrade 3