2019
Bisphosphonate-loaded Bone Cement as a Local Adjuvant Therapy for Giant Cell Tumor of Bone
Greenberg DD, Lee FY. Bisphosphonate-loaded Bone Cement as a Local Adjuvant Therapy for Giant Cell Tumor of Bone. American Journal Of Clinical Oncology 2019, 42: 231-237. PMID: 30811352, DOI: 10.1097/coc.0000000000000504.Peer-Reviewed Original ResearchConceptsGiant cell tumorAdjuvant therapyLocal adjuvant therapySystemic side effectsAvascular necrosisCell tumorsSide effectsMusculoskeletal Tumor Society scoreOsteoclast-like giant cellsAggressive bone resorptionTherapeutic Level IVHigh-speed burringLocal recurrence rateAtypical femur fracturesLevel of evidenceTraditional adjuvant therapyBone cementAtypical fracturesSystemic bisphosphonatesPulmonary metastasesSociety ScoreCurettage proceduresRecurrence rateFemur fracturesPolymethylmethacrylate bone cement
2014
Systemic Therapy in Patients with Resectable and Unresectable Cases of Giant Cell Tumor: A Systematic Review
Kaiser P, Compton J, Caldwell J, Hickernell T, Lee F. Systemic Therapy in Patients with Resectable and Unresectable Cases of Giant Cell Tumor: A Systematic Review. Journal Of Cancer Therapy 2014, 2014: 339-353. DOI: 10.4236/jct.2014.54041.Peer-Reviewed Original ResearchGiant cell tumorAnti-osteoclastic agentsSystemic bisphosphonatesSystemic treatmentResectable tumorsUnresectable casesRecurrence rateCell tumorsSide effectsCases of GCTMetastatic giant cell tumorUnresectable giant cell tumorPrimary giant cell tumorSevere side effect profileStabilization of diseaseOverall recurrence rateRetrospective case seriesSide effect profileSubset of patientsHigh-level evidenceSeries of patientsLow recurrence ratePrimary bone tumorsStandard of careCommon benign tumor