2018
Association Between Age and Patient‐Reported Changes in Voice and Swallowing After Thyroidectomy
Sahli Z, Canner J, Najjar O, Schneider E, Prescott J, Russell J, Tufano R, Zeiger M, Mathur A. Association Between Age and Patient‐Reported Changes in Voice and Swallowing After Thyroidectomy. The Laryngoscope 2018, 129: 519-524. PMID: 30194684, PMCID: PMC6344315, DOI: 10.1002/lary.27297.Peer-Reviewed Original ResearchConceptsSwallowing changesSwallowing alterationsRisk factorsIntraoperative recurrent laryngeal nerve monitoringIntact recurrent laryngeal nerveRecurrent laryngeal nerve monitoringPatient-reported voiceGastroesophageal reflux diseaseAdditional prospective studiesLaryngeal nerve monitoringRecurrent laryngeal nervePresence of malignancyImpact of ageInstitutional review boardIntact RLNReflux diseaseRLN injuryTotal thyroidectomyFrailty statusPatient ageConsecutive patientsFrailty indexRetrospective reviewLaryngeal nerveNerve monitoringAssociation of Parathyroid Hormone Level With Postthyroidectomy Hypocalcemia: A Systematic Review
Mathur A, Nagarajan N, Kahan S, Schneider E, Zeiger M. Association of Parathyroid Hormone Level With Postthyroidectomy Hypocalcemia: A Systematic Review. JAMA Surgery 2018, 153: 69-76. PMID: 29167863, DOI: 10.1001/jamasurg.2017.3398.Peer-Reviewed Original ResearchConceptsParathyroid hormone levelsPTH thresholdPTH levelsPrognostic significancePostthyroidectomy hypocalcemiaHormone levelsSystematic reviewTrue prognostic significanceAdditional prospective studiesEarly predictive markerDevelopment of hypocalcemiaFull-text publicationsLaboratory drawsTotal thyroidectomyCalcium supplementationCochrane DatabaseParathyroid hormoneProspective studyPredictive markerIndependent reviewersHypocalcemiaStudy characteristicsThyroidectomyHypocalcaemiaInitial search
2017
One‐Hour Postoperative Parathyroid Hormone Levels Do Not Reliably Predict Hypocalcemia After Thyroidectomy
Sahli Z, Najafian A, Kahan S, Schneider E, Zeiger M, Mathur A. One‐Hour Postoperative Parathyroid Hormone Levels Do Not Reliably Predict Hypocalcemia After Thyroidectomy. World Journal Of Surgery 2017, 42: 2128-2133. PMID: 29290070, PMCID: PMC5991999, DOI: 10.1007/s00268-017-4444-2.Peer-Reviewed Original ResearchConceptsPostoperative parathyroid hormone levelsPg/mLParathyroid hormone levelsPostoperative PTHPTH levelsBiochemical hypocalcemiaTotal thyroidectomyCalcium supplementationProspective studyHormone levelsAppropriate calcium supplementationDefinitive study designPostoperative biochemical hypocalcemiaAdditional prospective studiesNormal PTH levelsPTH decreaseCompletion thyroidectomyConsecutive patientsSerum calciumLow PTHPTH 1HypocalcemiaIRB approvalThyroidectomyPTH
2016
Evaluation of the Effect of Diagnostic Molecular Testing on the Surgical Decision-Making Process for Patients With Thyroid Nodules
Noureldine S, Najafian A, Han P, Olson M, Genther D, Schneider E, Prescott J, Agrawal N, Mathur A, Zeiger M, Tufano R. Evaluation of the Effect of Diagnostic Molecular Testing on the Surgical Decision-Making Process for Patients With Thyroid Nodules. JAMA Otolaryngology - Head & Neck Surgery 2016, 142: 676-82. PMID: 27196108, DOI: 10.1001/jamaoto.2016.0850.Peer-Reviewed Original ResearchConceptsSurgical decision-making processMolecular testingSurgical consultationThyroid nodulesDiagnostic molecular testingEvidence of overtreatmentPertinent treatment optionsSurgical management algorithmRisk of malignancySurgical decision makingSurgical management planRadiological resultsStudy cohortSurgical managementTreatment algorithmProspective studyMean ageTreatment optionsMAIN OUTCOMEPatientsBethesda SystemHistopathology diagnosisControl groupCytopathology classificationHistopathology analysisAssociation of BRAFV600E Mutation and MicroRNA Expression with Central Lymph Node Metastases in Papillary Thyroid Cancer: A Prospective Study from Four Endocrine Surgery Centers
Han PA, Kim HS, Cho S, Fazeli R, Najafian A, Khawaja H, McAlexander M, Dy B, Sorensen M, Aronova A, Sebo TJ, Giordano TJ, Fahey TJ, Thompson GB, Gauger PG, Somervell H, Bishop JA, Eshleman JR, Schneider EB, Witwer KW, Umbricht CB, Zeiger MA. Association of BRAFV600E Mutation and MicroRNA Expression with Central Lymph Node Metastases in Papillary Thyroid Cancer: A Prospective Study from Four Endocrine Surgery Centers. Thyroid 2016, 26: 532-542. PMID: 26950846, PMCID: PMC4827320, DOI: 10.1089/thy.2015.0378.Peer-Reviewed Original ResearchConceptsCentral lymph node metastasisCentral lymph node dissectionMultivariable logistic regression analysisPapillary thyroid cancerProphylactic central lymph node dissectionLogistic regression analysisLymph node dissectionAggressive clinicopathologic featuresLymph node metastasisEndocrine surgery centersStand-alone markerClinicopathologic featuresMiR-146bNode dissectionIndependent predictorsNode metastasisMiR-222Surgery centersThyroid cancerProphylactic lymph node dissectionRegression analysisIndividual prognostic markersOnly preoperative variablesNode-negative casesMicroRNA expression
2015
Clinical Presentation of Patients with a Thyroid Follicular Neoplasm: Are there Preoperative Predictors of Malignancy?
Najafian A, Olson M, Schneider E, Zeiger M. Clinical Presentation of Patients with a Thyroid Follicular Neoplasm: Are there Preoperative Predictors of Malignancy? Annals Of Surgical Oncology 2015, 22: 3007-3013. PMID: 25564170, DOI: 10.1245/s10434-014-4324-z.Peer-Reviewed Original ResearchConceptsMalignant follicular neoplasmsFollicular thyroid neoplasmFollicular neoplasmThyroid neoplasmsMalignant follicular thyroid neoplasmsFinal pathologic resultsPresentation of patientsHistory of headMultivariate logistic regressionOdds of malignancyPredictors of malignancyThyroid follicular neoplasmsFollicular thyroid lesionsConcomitant hyperthyroidismMethodsConsecutive patientsNeck radiationPreoperative predictorsClinical predictorsClinical featuresClinical presentationMale sexTertiary hospitalResultsA totalPhysical examinationPathologic results
2013
Does BRAF V600E Mutation Predict Aggressive Features in Papillary Thyroid Cancer? Results From Four Endocrine Surgery Centers
Li C, Han P, Lee K, Lee L, Fox A, Beninato T, Thiess M, Dy B, Sebo T, Thompson G, Grant C, Giordano T, Gauger P, Doherty G, Fahey T, Bishop J, Eshleman J, Umbricht C, Schneider E, Zeiger M. Does BRAF V600E Mutation Predict Aggressive Features in Papillary Thyroid Cancer? Results From Four Endocrine Surgery Centers. The Journal Of Clinical Endocrinology & Metabolism 2013, 98: 3702-3712. PMID: 23969188, DOI: 10.1210/jc.2013-1584.Peer-Reviewed Original ResearchConceptsCentral lymph node metastasisCentral lymph node dissectionPapillary thyroid cancerClassical variant papillary thyroid cancerRoutine central lymph node dissectionEndocrine surgery centersBRAF mutationsIndependent predictorsMultivariable analysisAggressive featuresBRAF statusSurgery centersThyroid cancerProphylactic central lymph node dissectionBivariate analysisPresence of LNMLymph node dissectionAggressive clinicopathologic featuresTumor-related factorsAmerican Joint CommitteeLymph node metastasisTreatment of patientsBRAF mutation statusBRAF V600E mutationCentral LNM
2012
Is BRAF mutation associated with lymph node metastasis in patients with papillary thyroid cancer?
Lee K, Li C, Schneider E, Wang Y, Somervell H, Krafft M, Umbricht C, Zeiger M. Is BRAF mutation associated with lymph node metastasis in patients with papillary thyroid cancer? Surgery 2012, 152: 977-983. PMID: 23062653, PMCID: PMC3715093, DOI: 10.1016/j.surg.2012.08.019.Peer-Reviewed Original ResearchConceptsCentral lymph node dissectionLymph node metastasisPapillary thyroid cancerBRAF mutation statusMutation statusBRAF mutationsNode metastasisSurgical managementClinicopathologic featuresThyroid cancerPresence of LNMRoutine central lymph node dissectionMultivariate logistic regression analysisLymph node dissectionAggressive clinicopathologic featuresInstitutional review board approvalLogistic regression analysisFine-needle aspirationFine-needle aspiration samplesReview board approvalNode dissectionTotal thyroidectomyLymphatic invasionChi-square analysisBoard approval
2011
Predictive factors of malignancy in pediatric thyroid nodules
Roy R, Kouniavsky G, Schneider E, Allendorf JD, Chabot JA, Logerfo P, Dackiw AP, Colombani P, Zeiger MA, Lee JA. Predictive factors of malignancy in pediatric thyroid nodules. Surgery 2011, 150: 1228-1233. PMID: 22136845, DOI: 10.1016/j.surg.2011.09.023.Peer-Reviewed Original ResearchConceptsFine-needle aspiration biopsy specimensPediatric thyroid nodulesPositive predictive valuePalpable lymphadenopathyThyroid nodulesThyroid cancerFamily historyPredictive valueAspiration biopsy specimensPediatric thyroidectomyFinal pathologyClinical factorsClinicopathologic factorsRetrospective reviewTertiary hospitalPredictive factorsHypoechoic lesionsBiopsy specimensHypoechoic nodulesIndeterminate lesionsMalignancyFNAB resultsLymphadenopathyGreater riskCancerThe role of preoperative neck ultrasounds to assess lymph nodes in patients with suspicious or indeterminate thyroid nodules
Roy R, Kouniavsky G, Venkat R, Felger E, Shiue Z, Schneider E, Zeiger M. The role of preoperative neck ultrasounds to assess lymph nodes in patients with suspicious or indeterminate thyroid nodules. Journal Of Surgical Oncology 2011, 105: 601-605. PMID: 22006435, PMCID: PMC3715078, DOI: 10.1002/jso.22115.Peer-Reviewed Original ResearchConceptsIndeterminate thyroid nodulesLymph nodesFormal lymph node dissectionThyroid nodulesPreoperative neck ultrasoundSuspicious lymph nodesLymph node dissectionSize of tumorCervical ultrasoundIndeterminate thyroid cytologyNode dissectionMetastatic diseaseNeck ultrasoundSurgical managementClinicopathological variablesPreoperative ultrasoundSurgical approachPreoperative neckUltrasound findingsMale genderMedical recordsOperative approachSurgical ultrasoundPatientsThyroid cytology