Dynamic contrast-enhanced MRI detects acute radiotherapy-induced alterations in mandibular microvasculature: prospective assessment of imaging biomarkers of normal tissue injury
Sandulache V, Hobbs B, Mohamed A, Frank S, Song J, Ding Y, Ger R, Court L, Kalpathy-Cramer J, Hazle J, Wang J, Awan M, Rosenthal D, Garden A, Gunn G, Colen R, Elshafeey N, Elbanan M, Hutcheson K, Lewin J, Chambers M, Hofstede T, Weber R, Lai S, Fuller C. Dynamic contrast-enhanced MRI detects acute radiotherapy-induced alterations in mandibular microvasculature: prospective assessment of imaging biomarkers of normal tissue injury. Scientific Reports 2016, 6: 29864. PMID: 27499209, PMCID: PMC4976364, DOI: 10.1038/srep29864.Peer-Reviewed Original ResearchConceptsDCE-MRIBone vascularizationHead and neck tumorsHead and neck cancerProspective imaging trialExternal beam radiotherapyDynamic contrast-enhanced MRINormal tissue injuryNormal tissue toxicityDCE-MRI scansContrast-enhanced MRIDetect dose-dependent changesDose-dependent alterationsDose-dependent changesMulti-parametric MRIBeam radiotherapyNeck tumorsTissue toxicityNeck cancerInstitutional experienceVascular injuryTissue injuryImaging trialsKtransImaging modalities