2024
Phase III randomized trial of intensity-modulated proton therapy (IMPT) versus intensity-modulated photon therapy (IMRT) for the treatment of head and neck oropharyngeal carcinoma (OPC).
Frank S, Busse P, Rosenthal D, Hernandez M, Swanson D, Garden A, Sturgis E, Ferrarotto R, Gunn G, Patel S, LEE N, Lin A, Snider J, McDonald M, Henson C, Bajaj G, Kalman N, Parvathaneni U, Katz S, Foote R. Phase III randomized trial of intensity-modulated proton therapy (IMPT) versus intensity-modulated photon therapy (IMRT) for the treatment of head and neck oropharyngeal carcinoma (OPC). Journal Of Clinical Oncology 2024, 42: 6006-6006. DOI: 10.1200/jco.2024.42.16_suppl.6006.Peer-Reviewed Original ResearchProgression-free survivalProgression-free survival HROverall survivalOropharyngeal carcinomaInduction chemotherapyChemoradiation therapyGastrostomy-tube dependenceHazard ratioRate of progression-free survivalManagement of head and neck tumorsIntensity-modulated photon therapyReceipt of induction chemotherapyTreated with chemoradiation therapyIntensity-modulated proton therapySurgical lymph node dissectionHead and neck tumorsPhase III randomized trialWeight loss <5%Bilateral neck treatmentHuman papillomavirus statusLymph node dissectionTarget tumor volumeMedian follow-upDe-intensification strategiesIntent-to-treat
2016
Dynamic contrast-enhanced MRI detects acute radiotherapy-induced alterations in mandibular microvasculature: prospective assessment of imaging biomarkers of normal tissue injury
Sandulache V, Hobbs B, Mohamed A, Frank S, Song J, Ding Y, Ger R, Court L, Kalpathy-Cramer J, Hazle J, Wang J, Awan M, Rosenthal D, Garden A, Gunn G, Colen R, Elshafeey N, Elbanan M, Hutcheson K, Lewin J, Chambers M, Hofstede T, Weber R, Lai S, Fuller C. Dynamic contrast-enhanced MRI detects acute radiotherapy-induced alterations in mandibular microvasculature: prospective assessment of imaging biomarkers of normal tissue injury. Scientific Reports 2016, 6: 29864. PMID: 27499209, PMCID: PMC4976364, DOI: 10.1038/srep29864.Peer-Reviewed Original ResearchConceptsDCE-MRIBone vascularizationHead and neck tumorsHead and neck cancerProspective imaging trialExternal beam radiotherapyDynamic contrast-enhanced MRINormal tissue injuryNormal tissue toxicityDCE-MRI scansContrast-enhanced MRIDetect dose-dependent changesDose-dependent alterationsDose-dependent changesMulti-parametric MRIBeam radiotherapyNeck tumorsTissue toxicityNeck cancerInstitutional experienceVascular injuryTissue injuryImaging trialsKtransImaging modalities