2021
Single cell immunophenotyping of the skin lesion erythema migrans Identifies IgM memory B cells
Jiang R, Meng H, Raddassi K, Fleming I, Hoehn KB, Dardick KR, Belperron AA, Montgomery RR, Shalek AK, Hafler DA, Kleinstein SH, Bockenstedt LK. Single cell immunophenotyping of the skin lesion erythema migrans Identifies IgM memory B cells. JCI Insight 2021, 6: e148035. PMID: 34061047, PMCID: PMC8262471, DOI: 10.1172/jci.insight.148035.Peer-Reviewed Original ResearchConceptsMemory B cellsErythema migransB cellsEM lesionsIgM memory B cellsLyme diseaseB-cell receptor sequencingSkin infection siteCell receptor sequencingEarly Lyme diseaseLocal antigen presentationSkin immune responsesB cell populationsSingle-cell immunophenotypingMHC class II genesUninvolved skinImmune cellsSpirochetal infectionAntigen presentationCell immunophenotypingT cellsImmune responseIsotype usageAntibody productionInitial signs
2014
Dual role for Fcγ receptors in host defense and disease in Borrelia burgdorferi-infected mice
Belperron AA, Liu N, Booth CJ, Bockenstedt LK. Dual role for Fcγ receptors in host defense and disease in Borrelia burgdorferi-infected mice. Frontiers In Cellular And Infection Microbiology 2014, 4: 75. PMID: 24967215, PMCID: PMC4052197, DOI: 10.3389/fcimb.2014.00075.Peer-Reviewed Original ResearchConceptsInnate immune cellsWild-type miceB. burgdorferi infectionB. burgdorferi-infected miceBurgdorferi-infected miceImmune cellsBurgdorferi infectionType micePathogen burdenHost defenseFc receptor common gamma chainIgG-mediated clearanceC-reactive proteinBorrelia burgdorferiToll-Like Receptor InteractionsSingle knockout miceCommon gamma chainAcute phaseInfected jointsArthritis severityMolecule MyD88Inflammatory cytokinesInflammatory pathwaysIL-1betaReactive protein