Anjelica Gonzalez, PhD
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Affiliated Faculty, Yale Institute for Global Health
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About
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Professor
Affiliated Faculty, Yale Institute for Global Health
Biography
Anjelica Gonzalez’ appointment in Biomedical Engineering in association with the Vascular Biology and Therapeutics Program has provided a supportive and convenient platform for her research, focused on the development of biomaterials for use as investigational tools, particularly for the investigation of immunological responses to inflammatory signals from endogenous and exogenous sources.
Gonzalez has a dedicated interest in training the next generation of scientists to think with an interdisciplinary approach to problem solving. The Gonzalez lab combines organic chemistry, molecular biology, mathematics, computational modeling and image analysis to develop and use engineered scaffolds to dissect the chemo-mechanics of immunological processes, specifically those related to microvascular structures. This work has special significance to an array of diseases and disorders, including acute and chronic inflammation and fibrosis.
Research projects in the Gonzalez lab include the development of biomaterials for investigating the influence of outside-in mediated signaling through adhesion molecules, the role of matrix architecture on cell behavior, and multicellular complex signaling in the microvasculature. These phenomena are investigated using human neutrophils, leukocytes and pericytes. Additionally, in collaboration with Yale School of Medicine Dept. of Dermatology and Pulmonary Medicine, Dr .Gonzalez is elucidating the mechanism of the dermal fibrosis and pulmonary fibrosis. Such work has led to an improved understanding of tissue homeostasis, disease genesis and progression, and the role of new therapeutics in treating human disease.
Appointments
Departments & Organizations
Education & Training
- PhD
- Baylor College of Medicine, Structural and Computational Biology (2004)
Research
Research at a Glance
Yale Co-Authors
Publications Timeline
Erica Herzog, MD, PhD
Asawari Korde
Farida Ahangari, MD
Geoffrey Chupp, MD
Ian Odell, MD, PhD, FAAD
Jordan Pober, MD, PhD
Publications
2024
TGF-β1 Drives Integrin-Dependent Pericyte Migration and Microvascular Destabilization in Fibrotic Disease
Pellowe A, Wu M, Kang T, Chung T, Ledesma-Mendoza A, Herzog E, Levchenko A, Odell I, Varga J, Gonzalez A. TGF-β1 Drives Integrin-Dependent Pericyte Migration and Microvascular Destabilization in Fibrotic Disease. American Journal Of Pathology 2024, 194: 1171-1184. PMID: 38548268, PMCID: PMC11220919, DOI: 10.1016/j.ajpath.2024.02.021.Peer-Reviewed Original ResearchCitationsAltmetricConceptsMechanosensing regulates tissue repair program in macrophages
Meizlish M, Kimura Y, Pope S, Matta R, Kim C, Philip N, Meyaard L, Gonzalez A, Medzhitov R. Mechanosensing regulates tissue repair program in macrophages. Science Advances 2024, 10: eadk6906. PMID: 38478620, PMCID: PMC10936955, DOI: 10.1126/sciadv.adk6906.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsExtracellular matrixRegulate chromatin accessibilityTissue repair programGene expression programsCytoskeletal dynamicsChromatin accessibilityAmoeboid migrationCytoskeletal remodelingBiochemical signalsTissue homeostasisExpression programsColony-stimulating factor-1Tissue-resident macrophagesFactor 1MechanosensingRegulating tissue repairTissue integrityMacrophagesTissueThree-dimensional environmentRepair programHomeostasis
2022
Endothelial Thrombopoietin Receptor Controls Eosinophil Trafficking in Asthma and Chronic Rhinosinusitis
Korde A, Haslip M, Ahangari F, Pober J, Chupp G, Manes P, Gonzalez A, Takyar S. Endothelial Thrombopoietin Receptor Controls Eosinophil Trafficking in Asthma and Chronic Rhinosinusitis. 2022, a5684-a5684. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5684.Peer-Reviewed Original Research
2018
Physical and biochemical interactions drive fibrocytes accumulation in the scleroderma lung matrix
Sun H, Winkler J, Minasyan M, Pan H, Desai O, Pellowe A, Li J, Peng X, Gonzalez A, Herzog E. Physical and biochemical interactions drive fibrocytes accumulation in the scleroderma lung matrix. 2018, lsc-1176. DOI: 10.1183/13993003.congress-2018.lsc-1176.Peer-Reviewed Original ResearchStroke Repair via Biomimicry of the Subventricular Zone
Matta R, Gonzalez A. Stroke Repair via Biomimicry of the Subventricular Zone. Frontiers In Materials 2018, 5: 15. DOI: 10.3389/fmats.2018.00015.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSubventricular zoneFunctional recoverySVZ nicheParticular neural stem cellsCurrent stroke therapiesEndogenous reparative mechanismsPeri-infarct areaBlood-brain barrierCause of deathEndogenous repair mechanismsMagnetic resonance imagingStem cellsNeural stem cellsResident cell typesSVZ microenvironmentCell typesStroke therapyNeurons migrateReparative mechanismsAxonal connectionsEpendymal cellsFunctional restorationResident cellsResonance imagingStroke repair
2015
Proteomic Analysis of the Pericyte Derived Extracellular Matrix
Brown L, Sava P, Garcia C, Gonzalez A. Proteomic Analysis of the Pericyte Derived Extracellular Matrix. Cellular And Molecular Bioengineering 2015, 8: 349-363. DOI: 10.1007/s12195-015-0408-5.Peer-Reviewed Original ResearchCitationsAltmetricConceptsMatrix proteinsStructural ECM proteinsBasic cellular responsesExtracellular matrix proteinsFunctional annotationProteomic analysisRegulatory signalsCell rufflingECM proteinsCellular responsesWestern blot analysisECM componentsExtracellular matrixEndothelial cell tubule formationFirst characterizationProteinMigratory velocityBlot analysisTubule formationECMNeutrophil polarizationStructural collagenVascular integrityLC/MS-MSBasement membrane
2014
Role of Pericytes in Tissue Engineering
Lauridsen H, Gonzalez A. Role of Pericytes in Tissue Engineering. 2014, 17-36. DOI: 10.1201/b16777-4.Peer-Reviewed Original ResearchChemically- and mechanically-tunable porated polyethylene glycol gels for leukocyte integrin independent and dependent chemotaxis
Lauridsen H, Walker B, Gonzalez A. Chemically- and mechanically-tunable porated polyethylene glycol gels for leukocyte integrin independent and dependent chemotaxis. Technology 2014, 2: 133-143. DOI: 10.1142/s2339547814500113.Peer-Reviewed Original ResearchCitationsConceptsHuman extracellular matrixExtracellular matrixInflammatory researchECM compositionBiochemical propertiesDependent chemotaxisProtein presentationProtein conjugationLeukocyte integrinsGrowth factorPolyethylene glycol hydrogelsGlass coverslipsGlycol hydrogelsPolyethylene glycol gelComplex mixturesProteinIntegrinsHydrogel pore sizeTranswellProteoglycansChemotaxisChronic inflammatory diseaseRecruitmentMembraneLeukocyte migration
2012
Approaches in extracellular matrix engineering for determination of adhesion molecule mediated single cell function
Ayres-Sander C, Gonzalez A. Approaches in extracellular matrix engineering for determination of adhesion molecule mediated single cell function. Frontiers In Biology 2012, 8: 32-49. DOI: 10.1007/s11515-012-1199-x.Peer-Reviewed Original ResearchCitationsConceptsCell-ECM interactionsCell adhesion moleculeExtracellular matrixThree-dimensional matrixCellular processesNative extracellular matrixAdhesion moleculesTwo-dimensional substratesSingle cell functionCell functionCell movementECM proteinsNative proteinPeptide sequencesIntegrin expressionBioactive peptide sequencesCell functionalityMatrix engineeringProteinHuman tissuesCellsDiseased tissuesCadherinMoleculesTissue
News
News
- May 21, 2021
Faculty Entrepreneurs Receive Research Support from Blavatnik Fund for Innovation at Yale
- March 03, 2021
Fifteen School of Medicine Faculty Members Are Among Those Newly Elected to CASE
- February 04, 2020
Using ‘the language of cells’ to find new treatments for asthma, allergies
- February 04, 2020
Using ‘the Language of Cells’ to Find New Treatments for Asthma, Allergies