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Clinical Immunology Laboratory

Clinical Immunology Lab

The Immunology Laboratory is responsible for laboratory testing and clinical consultation in several broad areas of Immunology, including the evaluation of autoimmune disease, immunodeficiencies, immunoproliferative disorders, and allergy. The work is carried out together with the Molecular Diagnostics , Microbiology, Virology and Hematology laboratories to provide seamless consultation and diagnostics for various clinical scenarios. The Laboratory also supports the activities of the GMP Cell Therapy Laboratory.

Faculty

  • Professor of Laboratory Medicine; Hematopathology Fellowship Director, Laboratory Medicine; Director, Molecular Diagnostics Laboratory, Laboratory Medicine; Director, Flow Cytometry, Laboratory Medicine; Associate Director, Hematology Laboratory, Laboratory Medicine

  • Professor of Laboratory Medicine, of Biomedical Engineering, of Medicine (Hematology) and of Pediatrics; Deputy Dean for Research, (Clinical and Translational); Director, Clinical Immunology Laboratory, Laboratory Medicine; Chair, Laboratory Medicine; Chief, Laboratory Medicine, Yale New Haven Hospital

Selected Publications

Wang S, Ernst LM., Smith BR, Tallini G, Howe JG, Crouch J, Cooper DL, 2003. Systemic Tropheryma whippleii infection associated with monoclonal B-cell proliferation: a Helicobacter pylori-type pathogenesis? Arch Pathol Lab Med 127:1619-22.

Fontes M, Mathew JP, Rinder HM, Zelterman D, Smith BR, Rinder CS. 2005. Atrial Fibrillation after Cardiopulmonary Bypass is Associated with Monocyte Activation. Anesthesia & Analgesia 101: 17-23.

Eisenbarth SC. The innate and adaptive immune systems in allergy: a two-way street. 2006. Clinical & Experimental Allergy. 36(2):135-7.

Rinder CS, Smith MJ, Rinder HM, Cortright DN, Brodbeck RM, Krause JE, Smith BR. 2007. Leukocyte effects of C5a Receptor Blockade during Simulated Extracorporeal Circulation. Ann Thorac Surg 83: 146-52.

Eisenbarth SC, Colegio OR, Iyer A, Cooper D, Bannykh S, Baehring J. 2007. Images in neuro-oncology: a case of POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal protein and Skin changes) in a patient with multicentric Castleman's disease. Journal of Neuro-Oncology. 81(2):163-5.

Greilich PE, Brouse CF, Rinder HM, Jessen ME, Rinder CS, Whitten CW, Eberhart RC, Smith BR. 2008. Differential markers and time course of monocyte activation in on- versus off-pump coronary artery bypass surgery. J Cardiothorac Vasc Anesthes 22: 361-8.

Eisenbarth SC, Colegio OR, O'Connor W, Sutterwala FS, Flavell RA. Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminum adjuvants. 2008. Nature. 453(7198):1122-6.