2023
Glia-neuron coupling via a bipartite sialylation pathway promotes neural transmission and stress tolerance in Drosophila
Scott H, Novikov B, Ugur B, Allen B, Mertsalov I, Monagas-Valentin P, Koff M, Robinson S, Aoki K, Veizaj R, Lefeber D, Tiemeyer M, Bellen H, Panin V. Glia-neuron coupling via a bipartite sialylation pathway promotes neural transmission and stress tolerance in Drosophila. ELife 2023, 12: e78280. PMID: 36946697, PMCID: PMC10110239, DOI: 10.7554/elife.78280.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDrosophilaNervous System Physiological PhenomenaNeurogliaNeuronsPolysaccharidesSynaptic TransmissionConceptsSialylation pathwayCMP-sialic acid synthetaseStress toleranceAnimal developmentProtein functionVoltage-gated sodium channelsGlycan terminiNeural transmissionDedicated pathwaysGenesDifferent cellsPathwayOxidative stressSodium channelsSialic acidNervous systemNeural excitabilitySialylationToleranceNormal levelsNeural functionDrosophilaTerminusExcitabilitySynthetase
2019
Highlights from the 29th Annual Meeting of the Society for the Neural Control of Movement
Mathis A, Pack A, Maeda R, McDougle S. Highlights from the 29th Annual Meeting of the Society for the Neural Control of Movement. Journal Of Neurophysiology 2019, 122: 1777-1783. PMID: 31461364, PMCID: PMC6843106, DOI: 10.1152/jn.00484.2019.Peer-Reviewed Original ResearchAnimalsCongresses as TopicHumansMovementNervous System Physiological PhenomenaNeurosciencesSocieties, Scientific
2018
Metals and oxidative potential in urban particulate matter influence systemic inflammatory and neural biomarkers: A controlled exposure study
Liu L, Urch B, Szyszkowicz M, Evans G, Speck M, Van Huang A, Leingartner K, Shutt RH, Pelletier G, Gold DR, Brook JR, Godri Pollitt K, Silverman FS. Metals and oxidative potential in urban particulate matter influence systemic inflammatory and neural biomarkers: A controlled exposure study. Environment International 2018, 121: 1331-1340. PMID: 30420132, PMCID: PMC6396878, DOI: 10.1016/j.envint.2018.10.055.Peer-Reviewed Original ResearchMeSH KeywordsAdultAir PollutantsBiomarkersFemaleHumansInflammationInhalation ExposureMaleMetalsMiddle AgedNervous System Physiological PhenomenaOntarioOxidantsOxidative StressParticulate MatterYoung AdultConceptsUbiquitin C-terminal hydrolase L1Vascular endothelium growth factorBiomarker levelsPost exposureSystemic inflammationOxidative stressNeural biomarkersS100 calcium-binding protein BCalcium-binding protein BNeural functionHealthy non-smoking volunteersConcentrated ambient PMAssessment of biomarkersNon-smoking volunteersStress marker cortisolAmbient PMUrinary malondialdehydeUrinary biomarkersUrinary cortisolInterleukin-6Mixed regression modelsVanillylmandelic acidInflammationMean concentrationGrowth factor
2014
From Attachment to Groups: Tapping Into the Neurobiology of Our Interconnectedness
Gordon I, Leckman JF, Berg DN. From Attachment to Groups: Tapping Into the Neurobiology of Our Interconnectedness. Journal Of The American Academy Of Child & Adolescent Psychiatry 2014, 53: 130-132. PMID: 24472246, DOI: 10.1016/j.jaac.2013.10.012.Peer-Reviewed Original ResearchAnimalsGroup ProcessesHumansInterpersonal RelationsNervous System Physiological PhenomenaObject Attachment
2013
High-speed laser microsurgery of alert fruit flies for fluorescence imaging of neural activity
Sinha S, Liang L, Ho ET, Urbanek KE, Luo L, Baer TM, Schnitzer MJ. High-speed laser microsurgery of alert fruit flies for fluorescence imaging of neural activity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 18374-18379. PMID: 24167298, PMCID: PMC3832030, DOI: 10.1073/pnas.1216287110.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntsBrainCalciumDrosophila melanogasterLasersMiceMicrosurgeryNematodaNervous System Physiological PhenomenaOptical ImagingTime-Lapse ImagingConceptsLive animalsCellular functionsFruit flySmall organismsMushroom bodiesKenyon cellsFliesAntennal lobeLive organismsOrganismsNeuronal plasticityHigh-throughput preparationMouse craniumExperimental throughputFluorescence imagingMicrosurgical openingLaser microsurgeryAntsVivo microscopy studiesNematodesAnimalsTwo-photon microscopySpeciesPhototaxisOptical experimentation
2008
Neuroimaging and Disorders of Consciousness: Envisioning an Ethical Research Agenda
Fins* J, Illes* J, Bernat** J, Hirsch** J, Laureys** S, Murphy** E. Neuroimaging and Disorders of Consciousness: Envisioning an Ethical Research Agenda. The American Journal Of Bioethics 2008, 8: 3-12. PMID: 18853371, DOI: 10.1080/15265160802318113.Peer-Reviewed Original ResearchMeSH KeywordsBrain InjuriesConsciousnessConsciousness DisordersCooperative BehaviorDiagnostic Techniques, NeurologicalEthics, ResearchHuman ExperimentationHumansNervous System Physiological PhenomenaNeurologyPainPatient SelectionPersistent Vegetative StatePhysical StimulationResearch DesignSocial JusticeThird-Party ConsentConceptsDisorders of consciousnessEthical research agendaEthical reflectionEthical framesScientific progressScientific backdropConsciousnessConscious stateLimited stateInterdisciplinary approachWorking meetingsResearch agendaEthicsNeuroethicsNeuroscientistsReflectionBackdropStanford UniversityAgendaUnderstandingConferenceTranslationLeptin reverses weight loss–induced changes in regional neural activity responses to visual food stimuli
Rosenbaum M, Sy M, Pavlovich K, Leibel RL, Hirsch J. Leptin reverses weight loss–induced changes in regional neural activity responses to visual food stimuli. Journal Of Clinical Investigation 2008, 118: 2583-2591. PMID: 18568078, PMCID: PMC2430499, DOI: 10.1172/jci35055.Peer-Reviewed Original ResearchMeSH KeywordsAdultAppetite RegulationBrainCerebral CortexEcho-Planar ImagingFemaleFoodHumansHypothalamusInjections, SubcutaneousLeptinLimbic SystemMaleNervous System Physiological PhenomenaOxygenPhotic StimulationWeight LossConceptsMiddle frontal gyrusNeural activityFood cuesFrontal gyrusFood-related visual cuesWeight lossFood intakeWeight loss-induced changesVisual food cuesVisual food stimuliMiddle temporal gyrusRelative leptin deficiencyWeight-reduced stateDaily subcutaneous injectionsBody weight maintenanceCognitive controlFood stimuliTemporal gyrusVisual cuesLeptin deficiencyObese subjectsWeight maintenanceLingual gyrusClinical managementFunctional MRI
2005
Neuroanatomical Phenotyping in the Mouse: The Dopaminergic System
Zeiss CJ. Neuroanatomical Phenotyping in the Mouse: The Dopaminergic System. Veterinary Pathology 2005, 42: 753-773. PMID: 16301571, DOI: 10.1354/vp.42-6-753.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBasal GangliaBasal Ganglia DiseasesBehavioral SymptomsDopamineImmunohistochemistryMiceModels, AnimalNervous System Physiological PhenomenaPhenotypePsychomotor PerformanceTyrosine 3-MonooxygenaseConceptsCentral dopaminergic systemDopaminergic systemBasal nucleusMouse modelHuntington's diseaseTyrosine hydroxylase immunohistochemistryNonhuman primate brainAttention deficit hyperactivity disorderIndividual mouse modelsDeficit hyperactivity disorderSpecific anatomic regionsHydroxylase immunohistochemistryDopaminergic dysfunctionDopamine metabolismHuman neurologic disordersNeurologic disordersPrimate brainReceptor functionPaucity of informationVoluntary movementAnatomic regionsDiseaseMiceHyperactivity disorderMotor tests
2004
Task analysis complements neuroimaging: an example from working memory research
Meegan D, Purc-Stephenson R, Honsberger M, Topan M. Task analysis complements neuroimaging: an example from working memory research. NeuroImage 2004, 21: 1026-1036. PMID: 15006670, DOI: 10.1016/j.neuroimage.2003.10.011.Peer-Reviewed Original ResearchMeSH KeywordsAcoustic StimulationAdultEye MovementsFemaleHumansMaleMemory, Short-TermMental RecallNervous SystemNervous System Physiological PhenomenaPsychomotor PerformanceSaccadesSpace PerceptionTask Performance and AnalysisVerbal LearningConceptsN-back taskLetter n-back taskTask analysisComplex behavioral tasksShort-term maintenanceMemory researchNeural basisMotor processesVerbal informationBehavioral tasksComponent processesVerbal processesBrain activityBehavioral experimentsFourth experimentTaskQuestion conclusionsMemorySpatial processesNeuroimagingSuch assumptionsResearchersResearchPartnersManipulation
2003
Imaging Nervous System Activity with Voltage‐Sensitive Dyes
Zecevic D, Djurisic M, Cohen LB, Antic S, Wachowiak M, Falk CX, Zochowski MR. Imaging Nervous System Activity with Voltage‐Sensitive Dyes. Current Protocols In Neuroscience 2003, 23: 6.17.1-6.17.29. PMID: 18428582, DOI: 10.1002/0471142301.ns0617s23.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsArtifactsBiomedical ResearchBrainColoring AgentsElectrophysiologyHumansMembrane PotentialsNervous System Physiological PhenomenaNeuronsNeurosciencesPhotonsSynapsesConceptsNumber of photonsVoltage-sensitive dyeVoltage-sensitive dye measurementsLight sourceShot noiseOptical recordingOptical recording methodSynaptic inputsChoice of dyeSimultaneous measurementNervous system activityAction potential outputAplysia abdominal ganglionLarge signalNoise ratioAbdominal ganglionNervous systemPhotonsDye measurementsOpticsMotor outputSystem activitySensory stimuliMeasurementsVertebrate brain
2001
The attentive homunculus: Now you see it, now you don't
Nobre A. The attentive homunculus: Now you see it, now you don't. Neuroscience & Biobehavioral Reviews 2001, 25: 477-496. PMID: 11595269, DOI: 10.1016/s0149-7634(01)00028-8.Peer-Reviewed Original ResearchConceptsAttentional control systemVisual spatial attentionNeural systemsAttentional controlBrain areasFrontal regionsSpatial attentionPattern of brain areasControl of visual spatial attentionVisual spatial orientingFunctional magnetic resonanceHuman brainPosterior parietal cortexFrontal eye fieldContribution of brain imagingMultiple frames of referenceIntraparietal sulcusParietal cortexEye fieldMotor actPositron emission tomographyEye movementsBrain imagingBrainMature understanding
2000
Taste as a factor in the management of nutrition
Scott T, Verhagen J. Taste as a factor in the management of nutrition. Nutrition 2000, 16: 874-885. PMID: 11054592, DOI: 10.1016/s0899-9007(00)00423-8.Peer-Reviewed Original ResearchAnimalsChemoreceptor CellsHumansNervous System Physiological PhenomenaNutritional Physiological PhenomenaSignal TransductionTasteTaste Buds
1998
Using Knockout and Transgenic Mice to Study Neurophysiology and Behavior
PICCIOTTO M, WICKMAN K. Using Knockout and Transgenic Mice to Study Neurophysiology and Behavior. Physiological Reviews 1998, 78: 1131-1163. PMID: 9790572, DOI: 10.1152/physrev.1998.78.4.1131.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnimalsBehavior, AnimalDisease Models, AnimalGene ExpressionHumansMental DisordersMiceMice, KnockoutMice, TransgenicNervous System DiseasesNervous System Physiological PhenomenaTransgenesNeuroimmunomodulation by Macrophage Migration Inhibitory Factor (MIF)
BUCALA R. Neuroimmunomodulation by Macrophage Migration Inhibitory Factor (MIF). Annals Of The New York Academy Of Sciences 1998, 840: 74-82. PMID: 9629239, DOI: 10.1111/j.1749-6632.1998.tb09551.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGlucocorticoidsHumansImmune SystemMacrophage Migration-Inhibitory FactorsNervous System Physiological PhenomenaNeuroimmunomodulationConceptsMacrophage migration inhibitory factorMigration inhibitory factorImmune responseRole of MIFInhibitory factorT cell cytokine productionAnti-inflammatory propertiesAnterior pituitary cellsT-lymphocyte factorSteroid therapyLymph nodesCytokine productionImmunosuppressive effectsInflammatory conditionsGlucocorticoid actionT cellsFirst cytokineInflammatory sitesTherapeutic strategiesProinflammatory stimuliPituitary cellsImmune systemLymphocyte factorsGlucocorticoidsInhibitory effect
1997
Neuronal and glial cell biology
De Camilli P, Mirsky R. Neuronal and glial cell biology. Current Opinion In Neurobiology 1997, 7: 595-597. PMID: 9384545, DOI: 10.1016/s0959-4388(97)80077-3.Peer-Reviewed Original Research
1996
A Family of Rat CRMP Genes Is Differentially Expressed in the Nervous System
Wang LH, Strittmatter SM. A Family of Rat CRMP Genes Is Differentially Expressed in the Nervous System. Journal Of Neuroscience 1996, 16: 6197-6207. PMID: 8815901, PMCID: PMC6579169, DOI: 10.1523/jneurosci.16-19-06197.1996.Peer-Reviewed Original ResearchMeSH KeywordsAgingAmino Acid SequenceAnimalsAnimals, NewbornEmbryonic and Fetal DevelopmentGanglia, SensoryGanglia, SympatheticGene ExpressionHumansIntercellular Signaling Peptides and ProteinsIsomerismMolecular Sequence DataMultigene FamilyNerve Tissue ProteinsNervous System Physiological PhenomenaProsencephalonRatsSemaphorin-3ASpinal CordEGL-10 Regulates G Protein Signaling in the C. elegans Nervous System and Shares a Conserved Domain with Many Mammalian Proteins
Koelle M, Horvitz H. EGL-10 Regulates G Protein Signaling in the C. elegans Nervous System and Shares a Conserved Domain with Many Mammalian Proteins. Cell 1996, 84: 115-125. PMID: 8548815, DOI: 10.1016/s0092-8674(00)80998-8.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAmino Acid SequenceAnimalsBase SequenceCaenorhabditis elegansCaenorhabditis elegans ProteinsConserved SequenceFungal ProteinsGene DosageGenes, HelminthGTP-Binding ProteinsMammalsMolecular Sequence DataMusclesMutationNervous SystemNervous System Physiological PhenomenaOvumProteinsRatsRGS ProteinsSerotoninSignal TransductionYeastsConceptsEGL-10G proteinsNematode C. elegansG protein signalingMammalian genesGOA-1Mammalian proteinsC. elegansConserved domainProtein signalingNegative regulatorNeurotransmitter signalingProteinSignalingDose-dependent mannerPathwaySst2pElegansYeastGenesNervous systemDose-dependent fashionRegulatorCertain periodic behaviorsActivity
1993
The Therapeutic Potential of Neurotrophic Factors in the Treatment of Parkinson's Disease
Lindsay R, Altar C, Cedarbaum J, Hyman C, Wiegand S. The Therapeutic Potential of Neurotrophic Factors in the Treatment of Parkinson's Disease. Experimental Neurology 1993, 124: 103-118. PMID: 8282068, DOI: 10.1006/exnr.1993.1181.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood-Brain BarrierBrainDopamineGrowth SubstancesHumansNerve Growth FactorsNerve Tissue ProteinsNervous System Physiological PhenomenaNeuronsParkinson DiseaseSubstantia NigraConceptsNeurotrophic factorParkinson's diseaseNeurodegenerative disordersTherapeutic agentsNeurodegenerative diseasesFetal nigral graftsTransplantation of neuronsDopamine neurotrophic factorPartial symptomatic reliefDopamine receptor agonistsNeurotrophic growth factorsPotential clinical useHuman neurodegenerative disordersAppropriate neurotransmittersObvious therapeutic strategyNeuronal lossNigral graftsSymptomatic reliefDevelopment of drugsDopaminergic neuronsNeuroprotective agentsSubstantia nigraNeuronal degenerationNeurotrophin familyDopamine neurons
1991
Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms
LaMotte R, Shain C, Simone D, Tsai E. Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms. Journal Of Neurophysiology 1991, 66: 190-211. PMID: 1919666, DOI: 10.1152/jn.1991.66.1.190.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnesthesia, LocalCapsaicinCentral Nervous SystemFemaleHumansHyperalgesiaLymphMaleMiddle AgedNerve FibersNervous System Physiological PhenomenaNeuronsPainPeripheral NervesPhysical StimulationPsychophysicsRegional Blood FlowSkinConceptsInjection of capsaicinMechanical hyperalgesiaNerve fibersInjection siteAlgesic substancesPrimary afferent nerve fibersArea of tendernessCapsaicin injection siteMicrograms of capsaicinNociceptive nerve fibersPeripheral neural activityArea of hyperalgesiaCutaneous nerve fibersAfferent nerve fibersMagnitude of painSingle intradermal injectionNeural activityArea of analgesiaSite of injuryLarger mean areaAnesthetized skinNeurogenic hyperalgesiaCutaneous anesthesiaIntradermal injectionPainful stimuliNeurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia
Baumann T, Simone D, Shain C, LaMotte R. Neurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia. Journal Of Neurophysiology 1991, 66: 212-227. PMID: 1919668, DOI: 10.1152/jn.1991.66.1.212.Peer-Reviewed Original ResearchMeSH KeywordsAfferent PathwaysAnimalsCapsaicinDose-Response Relationship, DrugHot TemperatureHyperalgesiaInjections, IntradermalMacaca fascicularisNerve FibersNervous System Physiological PhenomenaNociceptorsPainPhysical StimulationSkinConceptsAfferent fibersNeurogenic hyperalgesiaPrimary hyperalgesiaNociceptive fibersPrimary afferentsIntradermal injectionHeat stimuliInjection siteReceptive fieldsCutaneous primary afferent fibersCapsaicin injection siteCutaneous afferent fibersNociceptive afferent fibersInjection of capsaicinCapsaicin-induced painPrimary afferent fibersPeripheral nervous systemPeripheral neural mechanismsArea of skinCapsaicin painSecondary hyperalgesiaDepressed responsivenessCapsaicin injectionIntense painHyperalgesia
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