2023
Mechanotransduction events at the physiological site of touch detection
Ziolkowski L, Gracheva E, Bagriantsev S. Mechanotransduction events at the physiological site of touch detection. ELife 2023, 12: e84179. PMID: 36607222, PMCID: PMC9833821, DOI: 10.7554/elife.84179.Peer-Reviewed Original Research
2019
Functional alteration of ribbon synapses in inner hair cells by noise exposure causing hidden hearing loss
Liu H, Lu J, Wang Z, Song L, Wang X, Li G, Wu H. Functional alteration of ribbon synapses in inner hair cells by noise exposure causing hidden hearing loss. Neuroscience Letters 2019, 707: 134268. PMID: 31103727, DOI: 10.1016/j.neulet.2019.05.022.Peer-Reviewed Original ResearchConceptsInner hair cellsModerate noise exposureHearing lossRibbon synapsesNoise exposureHair cellsPersistent reductionWhole-cell patch-clamp recordingsNoise-induced hearing lossSynapse functionAuditory afferent fibersHidden hearing lossABR wave ISynaptic vesiclesAuditory brainstem response (ABR) amplitudesPatch-clamp recordingsSevere noise exposureWhole mount immunofluorescence stainingPatch-clamp electrophysiologySensory hair cellsAfferent fibersABR thresholdPersistent alterationsExposure altersFunctional alterations
2016
Innervation regulates synaptic ribbons in lateral line mechanosensory hair cells
Suli A, Pujol R, Cunningham DE, Hailey DW, Prendergast A, Rubel EW, Raible DW. Innervation regulates synaptic ribbons in lateral line mechanosensory hair cells. Journal Of Cell Science 2016, 129: 2250-2260. PMID: 27103160, PMCID: PMC4920245, DOI: 10.1242/jcs.182592.Peer-Reviewed Original ResearchConceptsMechanosensory hair cellsHair cellsWild-type larvaeZebrafish lateral line systemElectron-dense structuresRibbon formationProper synapsisLateral line systemMature synapseSynaptic vesiclesHair cell innervationPost-synaptic elementsSensory cellsBasolateral membranePresynaptic zoneAfferent fibersSynaptic ribbonsFunctional synapsesBalance disordersCellsInnervationMutantsSynapsesLarvaeCytoplasm
2012
Axonal regeneration induced by blockade of glial inhibitors coupled with activation of intrinsic neuronal growth pathways
Wang X, Hasan O, Arzeno A, Benowitz LI, Cafferty WB, Strittmatter SM. Axonal regeneration induced by blockade of glial inhibitors coupled with activation of intrinsic neuronal growth pathways. Experimental Neurology 2012, 237: 55-69. PMID: 22728374, PMCID: PMC3418451, DOI: 10.1016/j.expneurol.2012.06.009.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsAxonal regenerationPharmacological approachesCrush injuryChondroitin sulfate proteoglycanInjury siteNeural repairOptic nerve crush injuryDorsal root ganglion neuronsNgr1-/- miceNerve crush injurySciatic nerve axotomySpinal cord injury sitePrimary afferent fibersEffective pharmacological approachSpinal cord injuryAdult mammalian neuronsIntrinsic growth potentialGlial inhibitorsTriple therapyNerve axotomyViral gene therapyWT miceAfferent fibersCNS injury
2008
Locomotor Dysfunction and Pain: The Scylla and Charybdis of Fiber Sprouting After Spinal Cord Injury
Deumens R, Joosten E, Waxman S, Hains B. Locomotor Dysfunction and Pain: The Scylla and Charybdis of Fiber Sprouting After Spinal Cord Injury. Molecular Neurobiology 2008, 37: 52-63. PMID: 18415034, DOI: 10.1007/s12035-008-8016-1.Peer-Reviewed Original ResearchConceptsChronic painFiber sproutingAutonomic dysreflexiaMotor functionDorsal horn laminaePrimary afferent fibersSpinal cord injuryInterruption of connectionsDevelopment of therapiesMotor deficitsMotor dysfunctionNociceptive processingSensory fibersAfferent fibersCord injuryMotor fibersAberrant sproutingRegenerative sproutingSpinal cordLocomotor dysfunctionInhibitory barrierPainAxonal growthFiber tractsDysreflexia
2005
Mouse Taste Buds Use Serotonin as a Neurotransmitter
Huang Y, Maruyama Y, Lu K, Pereira E, Plonsky I, Baur J, Wu D, Roper S. Mouse Taste Buds Use Serotonin as a Neurotransmitter. Journal Of Neuroscience 2005, 25: 843-847. PMID: 15673664, PMCID: PMC6725637, DOI: 10.1523/jneurosci.4446-04.2005.Peer-Reviewed Original ResearchConceptsTaste budsPrimary sensory afferent fibersSensory afferent fibersBitter stimulationTransmitter release mechanismMouse taste budsAfferent fibersTransmitter candidatesGustatory receptor cellsIntracellular Ca2SerotoninSour tastantsReceptor cellsChinese hamster ovary cellsHamster ovary cellsNeurotransmittersSynapsesStimulationOvary cellsReleaseCa2CellsAcetylcholineCNSReceptors
2004
Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization
Huang EJ, Li H, Tang AA, Wiggins AK, Neve RL, Zhong W, Jan LY, Jan YN. Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization. Genes & Development 2004, 19: 138-151. PMID: 15598981, PMCID: PMC540232, DOI: 10.1101/gad.1246005.Peer-Reviewed Original ResearchConceptsNuclear Notch1Sensory neuronsAxon arborizationAccumulation of Notch1Conditional mouse mutantsAxon branch pointsAfferent fibersSensory gangliaAxonal arborizationAxonal lengthSevere reductionAxon lengthArborizationCre recombinaseNotch1Endocytic-lysosomal pathwayTargeted deletionSignificant increaseUnknown mechanismNeuronsOverexpression of NumbMouse mutantsGangliaNeurogenesisPathway
1997
Distinct but Overlapping Populations of Commissural and GABAergic Neurons in the Dorsal Nucleus of the Little Skate, Raja erinacea
Duman C, Bodznick D. Distinct but Overlapping Populations of Commissural and GABAergic Neurons in the Dorsal Nucleus of the Little Skate, Raja erinacea. Brain Behavior And Evolution 1997, 49: 99-109. PMID: 9031733, DOI: 10.1159/000112984.Peer-Reviewed Original ResearchConceptsDorsal nucleusCommissural cellsAnimal's own ventilationPrimary afferent fibersCell body areaPrevious electrophysiological studiesGABA-immunoreactiveInhibitory transmitterGABAergic neuronsPrimary afferentsAfferent fibersRetrograde tracerCommissural pathwayImmunohistochemical studyRaja erinaceaStellate cellsElectrophysiological studiesElectrosensory primary afferentsCell groupsMajor efferentsBody areasElectrosensory cellsPeripheral zoneOverlapping populationsLittle skate
1991
Neurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia
Baumann T, Simone D, Shain C, LaMotte R. Neurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia. Journal Of Neurophysiology 1991, 66: 212-227. PMID: 1919668, DOI: 10.1152/jn.1991.66.1.212.Peer-Reviewed Original ResearchConceptsAfferent fibersNeurogenic hyperalgesiaPrimary hyperalgesiaNociceptive fibersPrimary afferentsIntradermal injectionHeat stimuliInjection siteReceptive fieldsCutaneous primary afferent fibersCapsaicin injection siteCutaneous afferent fibersNociceptive afferent fibersInjection of capsaicinCapsaicin-induced painPrimary afferent fibersPeripheral nervous systemPeripheral neural mechanismsArea of skinCapsaicin painSecondary hyperalgesiaDepressed responsivenessCapsaicin injectionIntense painHyperalgesiaDifferential sensitivity to hypoxia of the peripheral versus central trajectory of primary afferent axons
Utzschneider D, Kocsis J, Waxman S. Differential sensitivity to hypoxia of the peripheral versus central trajectory of primary afferent axons. Brain Research 1991, 551: 136-141. PMID: 1913145, DOI: 10.1016/0006-8993(91)90924-k.Peer-Reviewed Original ResearchConceptsDorsal columnsDorsal rootsAfferent fibersCentral nervous system componentsPrimary afferent fibersSucrose gap chamberAction potential amplitudePrimary afferent axonsCompound action potentialDorsal spinal rootsNervous system componentsAxonal trunksPeripheral nervesSpinal cordSpinal rootsAfferent axonsCNS portionSchwann cellsAdult ratsPotential amplitudeAxon branchesAction potentialsHypoxiaMembrane potential changesMembrane depolarizationA novel cytoarchitectonic area induced experimentally within the primate visual cortex.
Rakic P, Suñer I, Williams R. A novel cytoarchitectonic area induced experimentally within the primate visual cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 1991, 88: 2083-2087. PMID: 2006147, PMCID: PMC51173, DOI: 10.1073/pnas.88.6.2083.Peer-Reviewed Original ResearchConceptsArea 17Cytoarchitectonic areasVisual cortexSecondary visual cortexPrimary visual cortexPrimate visual cortexAfferent fibersCerebral cortexCortical neuronsThalamic inputsCortical connectionsThalamic fibersCytoarchitectonic regionsCortexCortical parcellationAberrant combinationsArea XProtomap hypothesisCell-cell interactionsNeurons
1990
Tactile detection of slip: surface microgeometry and peripheral neural codes
Srinivasan M, Whitehouse J, LaMotte R. Tactile detection of slip: surface microgeometry and peripheral neural codes. Journal Of Neurophysiology 1990, 63: 1323-1332. PMID: 2358880, DOI: 10.1152/jn.1990.63.6.1323.Peer-Reviewed Original Research
1988
Presynaptic actions of carbachol and adenosine on corticostriatal synaptic transmission studied in vitro
Malenka R, Kocsis J. Presynaptic actions of carbachol and adenosine on corticostriatal synaptic transmission studied in vitro. Journal Of Neuroscience 1988, 8: 3750-3756. PMID: 2848109, PMCID: PMC6569613, DOI: 10.1523/jneurosci.08-10-03750.1988.Peer-Reviewed Original ResearchConceptsStriatal neuronsSynaptic transmissionCorticostriatal synaptic transmissionExcitatory amino acidsField potentialsNeostriatal slice preparationField potential responsesCorticostriatal afferentsCorticostriatal responsesCorticostriatal fibersPresynaptic actionPostsynaptic actionsStriatal neurotransmittersCalcium antagonistsCarbachol actionCortical afferentsAfferent fibersIntrinsic neuronsStriatal afferentsPutative neurotransmittersAdenosine actionSlice preparationCorpus callosumNeostriatal slicesAfferentsBuspirone, 8-OH-DPAT and ipsapirone: effects on hippocampal cerebellar and sciatic fiber excitability
Hiner B, Mauk M, Peroutka S, Kocsis J. Buspirone, 8-OH-DPAT and ipsapirone: effects on hippocampal cerebellar and sciatic fiber excitability. Brain Research 1988, 461: 1-9. PMID: 2906267, DOI: 10.1016/0006-8993(88)90719-6.Peer-Reviewed Original ResearchConceptsCerebellar parallel fibersSerotonergic mechanismsNerve excitabilityFiber excitabilityAction potentialsSucrose gap recordingsEffects of serotoninNovel anxiolytic buspironeCompound action potentialDose-dependent reductionSchaffer collateral fibersParallel fibersAfferent fibersSciatic nerveReversible decrementsCollateral fibersAnxiolytic buspironeConduction velocityDPATIpsapironeGap recordingsBuspironeCerebellar neuronsAxonal responseExcitabilityBuspirone attenuates synaptic activation of hippocampal pyramidal cells
Mauk, Peroutka S, Kocsis J. Buspirone attenuates synaptic activation of hippocampal pyramidal cells. Journal Of Neuroscience 1988, 8: 1-11. PMID: 3339401, PMCID: PMC6569355, DOI: 10.1523/jneurosci.08-01-00001.1988.Peer-Reviewed Original ResearchConceptsExcitatory postsynaptic potentialsPyramidal cellsStratum radiatumSynaptic activationAfferent fibersHippocampal CA1 pyramidal cellsInput resistanceStimulation of afferentsEffects of buspironeCA1 pyramidal cellsHippocampal pyramidal cellsPostsynaptic potentialsPresynaptic fibersConduction slowingFiber excitabilitySpike activityAnxiolytic agentsBuspironeRefractory periodRadiatumRapid hyperpolarizationReceptor sitesMeasurable effectExcitabilityMembrane potential
1984
Time-intensity profiles of cutaneous pain in normal and hyperalgesic skin: a comparison with C-fiber nociceptor activities in monkey and human
LaMotte R, Torebjörk H, Robinson C, Thalhammer J. Time-intensity profiles of cutaneous pain in normal and hyperalgesic skin: a comparison with C-fiber nociceptor activities in monkey and human. Journal Of Neurophysiology 1984, 51: 1434-1450. PMID: 6737035, DOI: 10.1152/jn.1984.51.6.1434.Peer-Reviewed Original ResearchConceptsNociceptive afferent fibersDevelopment of hyperalgesiaConditioning stimulusPain ratingsHeat stimulationAfferent fibersHairy skinHeat-evoked dischargesCervical spinal cordMagnitude of painMild heat injurySimilar response magnitudesMean frequencyPoststimulus time histogramsNociceptor activityCutaneous painResponse latencyHyperalgesic skinSpinal cordAwake humansC-fibersAnesthetized monkeysConduction velocityPainHeat stimuliThe Role of C-Nociceptors in Cutaneous Heat Pain and Hyperalgesia
Lamotte R. The Role of C-Nociceptors in Cutaneous Heat Pain and Hyperalgesia. Ettore Majorana International Science Series 1984, 363-377. DOI: 10.1007/978-1-4613-2807-0_26.Peer-Reviewed Original ResearchCutaneous heat painHeat painCutaneous nociceptorsHeat pain thresholdNoxious heat stimuliSensation of painPeripheral neural mechanismsHeat injuryC-nociceptorsNociceptor responsesPain thresholdAfferent fibersCutaneous receptorsPainCutaneous injuryHeat stimuliHyperalgesiaNociceptorsNeurophysiological studiesInjuryNeural mechanismsMagnitude ratingsPsychophysical studiesStimuliStudy
1981
Modulation of Parallel Fiber Excitability by Postsynaptically Mediated Changes in Extracellular Potassium
Malenka R, Kocsis J, Ransom B, Waxman S. Modulation of Parallel Fiber Excitability by Postsynaptically Mediated Changes in Extracellular Potassium. Science 1981, 214: 339-341. PMID: 7280695, DOI: 10.1126/science.7280695.Peer-Reviewed Original ResearchConceptsSynaptic field potentialsField potentialsParallel fiber stimulationExtracellular potassium concentrationRat cerebellar cortexParallel fibersAfferent fibersPostsynaptic elementsFiber excitabilityCerebellar cortexExtracellular potassiumFiber stimulationExcitabilityMarked increasePotassium concentrationStimulationMolecular layer
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