2023
Glia-neuron coupling via a bipartite sialylation pathway promotes neural transmission and stress tolerance in Drosophila
Scott H, Novikov B, Ugur B, Allen B, Mertsalov I, Monagas-Valentin P, Koff M, Robinson S, Aoki K, Veizaj R, Lefeber D, Tiemeyer M, Bellen H, Panin V. Glia-neuron coupling via a bipartite sialylation pathway promotes neural transmission and stress tolerance in Drosophila. ELife 2023, 12: e78280. PMID: 36946697, PMCID: PMC10110239, DOI: 10.7554/elife.78280.Peer-Reviewed Original ResearchConceptsSialylation pathwayCMP-sialic acid synthetaseStress toleranceAnimal developmentProtein functionVoltage-gated sodium channelsGlycan terminiNeural transmissionDedicated pathwaysGenesDifferent cellsPathwayOxidative stressSodium channelsSialic acidNervous systemNeural excitabilitySialylationToleranceNormal levelsNeural functionDrosophilaTerminusExcitabilitySynthetase
2022
Characterization of the COPD alveolar niche using single-cell RNA sequencing
Sauler M, McDonough JE, Adams TS, Kothapalli N, Barnthaler T, Werder RB, Schupp JC, Nouws J, Robertson MJ, Coarfa C, Yang T, Chioccioli M, Omote N, Cosme C, Poli S, Ayaub EA, Chu SG, Jensen KH, Gomez JL, Britto CJ, Raredon MSB, Niklason LE, Wilson AA, Timshel PN, Kaminski N, Rosas IO. Characterization of the COPD alveolar niche using single-cell RNA sequencing. Nature Communications 2022, 13: 494. PMID: 35078977, PMCID: PMC8789871, DOI: 10.1038/s41467-022-28062-9.Peer-Reviewed Original ResearchConceptsSingle-cell RNA sequencingRNA sequencingCell-specific mechanismsChronic obstructive pulmonary diseaseAdvanced chronic obstructive pulmonary diseaseTranscriptomic network analysisSingle-cell RNA sequencing profilesCellular stress toleranceAberrant cellular metabolismStress toleranceRNA sequencing profilesTranscriptional evidenceCellular metabolismAlveolar nicheSequencing profilesHuman alveolar epithelial cellsChemokine signalingAlveolar epithelial type II cellsObstructive pulmonary diseaseSitu hybridizationType II cellsEpithelial type II cellsSequencingCOPD pathobiologyHuman lung tissue samples
2014
P436Role of myocardial proteostasis in hypoxic tolerance: effect of chemical chaperones and er stress inducers
Jain K, Ganju L, Suryakumar G. P436Role of myocardial proteostasis in hypoxic tolerance: effect of chemical chaperones and er stress inducers. Cardiovascular Research 2014, 103: s80-s80. DOI: 10.1093/cvr/cvu091.115.Peer-Reviewed Original ResearchChemical chaperonesProtein modificationER stressStress inducersHypoxic toleranceRole of proteinsOxidative protein modificationsER stress inducersHeat shock protein expressionStress toleranceProtein homeostasisInhibition of apoptosisProtein misfoldingShock protein expressionEnvironmental stressHarsh environmental conditionsExpression analysisER stress activationChaperonesUPR markersGreater protein oxidationER stress markersBiochemical assaysEnvironmental conditionsProtein oxidation
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