2025
Diagnosis of cancer therapy-related cardiovascular toxicities: A multimodality integrative approach and future developments
Travers S, Alexandre J, Baldassarre L, Salem J, Mirabel M. Diagnosis of cancer therapy-related cardiovascular toxicities: A multimodality integrative approach and future developments. Archives Of Cardiovascular Diseases 2025, 118: 185-198. PMID: 39947997, DOI: 10.1016/j.acvd.2024.12.012.Peer-Reviewed Original ResearchConceptsCardio-OncologyCardiovascular toxicityCardiovascular imagingMultimodality cardiovascular imagingCancer risk factorsIncrease diagnostic accuracyPrognostic stratificationNatriuretic peptideSerum biomarkersTherapy schemesDiagnostic accuracyCancer therapyRhythm disordersRisk factorsCardiovascular diseaseBiomarkersMultimodal integrated approachCancerOmics approachesToxicityRhythmTherapyTroponinSerumDiagnosis
2024
The Integration of Clinical Trials With the Practice of Medicine
Angus D, Huang A, Lewis R, Abernethy A, Califf R, Landray M, Kass N, Bibbins-Domingo K, Abbasi A, Abebe K, Abernethy A, Adam S, Angus D, Ard J, Berkwits M, Bender Ignacio R, Berry S, Bhatt D, Bibbins-Domingo K, Bonow R, Bonten M, Brangman S, Brownstein J, Buntin M, Butte A, Califf R, Campbell M, Cappola A, Chiang A, Cook D, Cummings S, Curfman G, Esserman L, Fleisher L, Franklin J, Gonzalez R, Grossman C, Haddad T, Herbst R, Hernandez A, Holder D, Horn L, Huang G, Huang A, Kass N, Khera R, Koroshetz W, Krumholz H, Landray M, Lewis R, Lieu T, Malani P, Martin C, McClellan M, McDermott M, Morain S, Murphy S, Nicholls S, Nicholls S, O'Dwyer P, Patel B, Peterson E, Prindiville S, Ross J, Rowan K, Rubenfeld G, Seymour C, Taylor R, Waldstreicher J, Wang T. The Integration of Clinical Trials With the Practice of Medicine. JAMA 2024, 332: 153-162. PMID: 38829654, PMCID: PMC12045079, DOI: 10.1001/jama.2024.4088.Peer-Reviewed Original ResearchMeSH KeywordsCommunicationDelivery of Health CareDiffusion of InnovationHealth Services AccessibilityHumansPatient CareRandomized Controlled Trials as TopicUnited StatesConceptsHealth care delivery enterpriseHealth care deliveryCare deliveryIntegrity of clinical trialsRandomized clinical trialsHealth careOptimal health care deliveryHealth care delivery systemCare delivery systemLearning health systemElectronic health recordsPractice of medicineHealth recordsImplementation scienceHealth systemHealth dataOptimal careQuality improvementCareNonfinancial incentivesVulnerable populationsPoor accessStudy designClinical trialsHealth
2023
Pivotal Trial Demographic Representation and Clinical Development Times for Oncology Therapeutics
Wong A, Miller J, Mooghali M, Ramachandran R, Ross J, Wallach J. Pivotal Trial Demographic Representation and Clinical Development Times for Oncology Therapeutics. JAMA 2023, 330: 2392-2394. PMID: 38079163, PMCID: PMC10714278, DOI: 10.1001/jama.2023.21958.Peer-Reviewed Original Research
2022
Advancing Public Health Entrepreneurship to Foster Innovation and Impact
Huang T, Ciari A, Costa S, Chahine T. Advancing Public Health Entrepreneurship to Foster Innovation and Impact. Frontiers In Public Health 2022, 10: 923764. PMID: 35692320, PMCID: PMC9184719, DOI: 10.3389/fpubh.2022.923764.Peer-Reviewed Original Research
2021
Transforming the Care of Patients with Diabetic Kidney Disease
Brosius FC, Cherney D, Gee PO, Harris RC, Kliger A, Tuttle KR, Quaggin SE. Transforming the Care of Patients with Diabetic Kidney Disease. Clinical Journal Of The American Society Of Nephrology 2021, 16: 1590-1600. PMID: 34103350, PMCID: PMC8499007, DOI: 10.2215/cjn.18641120.Commentaries, Editorials and LettersConceptsRenin-angiotensin system inhibitorsDiabetic kidney diseaseIrbesartan Diabetic Nephropathy TrialCare of patientsKidney diseaseSystem inhibitorsNew therapiesAngiotensin II Antagonist Losartan (RENAAL) trialAngiotensin II type 1 receptor blockerDiabetic kidney disease progressionType 1 receptor blockerCardiovascular protective therapiesReduction of EndpointsKidney disease progressionKidney protective effectsRenin-angiotensin systemDiabetic Nephropathy TrialRisk of deathHigh residual riskHealth care providersPowerful new therapiesNephropathy TrialReceptor blockersDevastating complicationAntihypertensive agentsUptake of evidence by physicians: De-adoption of erythropoiesis-stimulating agents after the TREAT trial
Vu K, Zhou J, Everhart A, Desai N, Herrin J, Jena AB, Ross JS, Shah ND, Karaca-Mandic P. Uptake of evidence by physicians: De-adoption of erythropoiesis-stimulating agents after the TREAT trial. BMC Nephrology 2021, 22: 284. PMID: 34419007, PMCID: PMC8379779, DOI: 10.1186/s12882-021-02491-y.Peer-Reviewed Original ResearchConceptsErythropoiesis-stimulating agentsChronic kidney diseaseEpoetin alfaDarbepoetin alfaTREAT trialTypes of ESAsNew clinical evidencePrimary care physiciansMedicare AdvantageUptake of evidenceCare physiciansAnemia treatmentClinical evidenceKidney diseasePhysician genderMedicare feeUnsafe treatmentSegmented regression approachStudy periodPhysiciansService populationConsistent changesAlfaHigher useTreatmentACEP SimBox: A Pediatric Simulation-Based Training Innovation
Vora S, Li J, Kou M, Ng V, Price A, Claudius I, Kant S, Sanseau E, Madhok M, Auerbach M. ACEP SimBox: A Pediatric Simulation-Based Training Innovation. Annals Of Emergency Medicine 2021, 78: 346-354. PMID: 34154842, DOI: 10.1016/j.annemergmed.2021.03.040.Peer-Reviewed Original Research
2020
Inflection Point
Krumholz HM. Inflection Point. Circulation Cardiovascular Quality And Outcomes 2020, 13: e007615-e007615. PMID: 33200951, PMCID: PMC7742208, DOI: 10.1161/circoutcomes.120.007615.Peer-Reviewed Original ResearchFrom Bench to Every Bedside: Improving the Adoption of Evidence-Based Practices.
Rodwin BA, Merchant NB. From Bench to Every Bedside: Improving the Adoption of Evidence-Based Practices. Southern Medical Journal 2020, 113: 538-540. PMID: 33140105, DOI: 10.14423/smj.0000000000001163.Peer-Reviewed Original ResearchDiffusion of InnovationEvidence-Based MedicineGuideline AdherenceHumansQuality ImprovementUnited StatesSocial innovation in global health: sparking location action
Halpaap BM, Tucker JD, Mathanga D, Juban N, Awor P, Saravia NG, Han L, de Villiers K, Kitamura M, Cuervo LG, Peeling R, Reeder JC. Social innovation in global health: sparking location action. The Lancet Global Health 2020, 8: e633-e634. PMID: 32353305, DOI: 10.1016/s2214-109x(20)30070-x.Peer-Reviewed Original Research
2019
A semicentennial of pancreatic pathology: the genetic revolution is here, but don’t throw the baby out with the bath water!
Hruban R, Klimstra D, Zamboni G, Klöppel G. A semicentennial of pancreatic pathology: the genetic revolution is here, but don’t throw the baby out with the bath water! Human Pathology 2019, 95: 99-112. PMID: 31521627, DOI: 10.1016/j.humpath.2019.08.024.Peer-Reviewed Original ResearchPreventing injuries must be a priority to prevent disease in the twenty-first century
Dorney K, Dodington JM, Rees CA, Farrell CA, Hanson HR, Lyons TW, Lee LK. Preventing injuries must be a priority to prevent disease in the twenty-first century. Pediatric Research 2019, 87: 282-292. PMID: 31466080, DOI: 10.1038/s41390-019-0549-7.Commentaries, Editorials and LettersMeSH KeywordsAdolescentAge FactorsChildChild, PreschoolDiffusion of InnovationFemaleForecastingHumansInfantMalePreventive MedicineWounds and InjuriesYoung AdultConceptsYoung adultsHome-related injuriesInjury-related deathsCause of morbidityCause of deathEducation of caregiversMotor vehicle crashesSubmersion injuryEmergency departmentInjury deathsLifelong morbidityClinical providersAnticipatory guidanceInjury mechanismNonfatal injuriesUnintentional deathsInjuryAge groupsDeathVehicle crashesMorbidityYoung childrenCauseChildrenMulti-pronged approachA Network Approach to Stroke Systems of Care
Zachrison K, Dhand A, Schwamm L, Onnela J. A Network Approach to Stroke Systems of Care. Circulation Cardiovascular Quality And Outcomes 2019, 12: e005526. PMID: 31405293, PMCID: PMC6822608, DOI: 10.1161/circoutcomes.119.005526.Peer-Reviewed Original ResearchIntroduction of Novel Surgical Techniques: A Survey on Knowledge, Attitude, and Practice of Surgeons
Ahmed A, Giang H, Ghozy S, Salem H, Algazar M, Altibi A, Son H, Anh T, Cuong T, Tuan L, Vuong N, Abdou M, Ghorab M, Tran N, Elawady S, Elmaraezy A, Minh L, Hirayama K, Huy N. Introduction of Novel Surgical Techniques: A Survey on Knowledge, Attitude, and Practice of Surgeons. Surgical Innovation 2019, 26: 560-572. PMID: 31130082, DOI: 10.1177/1553350619849127.Peer-Reviewed Original ResearchConceptsNovel surgical techniqueSurgical techniquePractice of surgeonsEvidence-based guidelinesLevel of educationLength of lifeModern surgical careSurgical careTraining programMeta-analysesSurgeon experienceJunior surgeonsResponse rateCareSurgeonsEvent ratesPatientsAttitudesPracticeSurveyDeveloping worldPractical questions
2018
The Role of Artificial Intelligence in Interventional Oncology: A Primer
Letzen B, Wang CJ, Chapiro J. The Role of Artificial Intelligence in Interventional Oncology: A Primer. Journal Of Vascular And Interventional Radiology 2018, 30: 38-41.e1. PMID: 30528289, DOI: 10.1016/j.jvir.2018.08.032.Peer-Reviewed Original ResearchThe Use of Technology by Youth: Implications for Psychiatric Educators
Joshi SV, Stubbe D, Li ST, Hilty DM. The Use of Technology by Youth: Implications for Psychiatric Educators. Academic Psychiatry 2018, 43: 101-109. PMID: 30446956, PMCID: PMC6394428, DOI: 10.1007/s40596-018-1007-2.Peer-Reviewed Original ResearchCredibility-enhancing displays promote the provision of non-normative public goods
Kraft-Todd G, Bollinger B, Gillingham K, Lamp S, Rand D. Credibility-enhancing displays promote the provision of non-normative public goods. Nature 2018, 563: 245-248. PMID: 30356217, DOI: 10.1038/s41586-018-0647-4.Peer-Reviewed Original ResearchBuilding capacity for advances in tuberculosis research; proceedings of the third RePORT international meeting
van der Heijden Y, Abdullah F, Andrade B, Andrews J, Christopher D, Croda J, Ewing H, Haas D, Hatherill M, Horsburgh C, Mave V, Nakaya H, Rolla V, Srinivasan S, Sugiyono R, Ugarte-Gil C, Hamilton C. Building capacity for advances in tuberculosis research; proceedings of the third RePORT international meeting. Tuberculosis 2018, 113: 153-162. PMID: 30514497, PMCID: PMC6349374, DOI: 10.1016/j.tube.2018.09.009.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomedical ResearchCooperative BehaviorDiffusion of InnovationHumansInformation DisseminationInternational CooperationStakeholder ParticipationTuberculosisConceptsType 2 diabetes mellitusTuberculosis researchActive pulmonary tuberculosisHigh-risk populationEnrollment of participantsContext of HIVUnderstanding of tuberculosisHousehold contactsActive tuberculosisObservational cohortPulmonary tuberculosisDiabetes mellitusTuberculosis transmissionClinical dataIncipient tuberculosisNovel biomarkersTB participantsHost immunityStandardized research protocolsTuberculosisResearch capacity developmentHIVResearch protocolBiomarker identificationInternational meetingsDisruptive innovation in acute stroke systems of care
Schwamm L. Disruptive innovation in acute stroke systems of care. The Lancet Neurology 2018, 17: 576-578. PMID: 29807813, DOI: 10.1016/s1474-4422(18)30197-2.Peer-Reviewed Original Research
2017
2017 Roadmap for Innovation—ACC Health Policy Statement on Healthcare Transformation in the Era of Digital Health, Big Data, and Precision Health A Report of the American College of Cardiology Task Force on Health Policy Statements and Systems of Care
Bhavnani SP, Parakh K, Atreja A, Druz R, Graham GN, Hayek SS, Krumholz HM, Maddox TM, Majmudar MD, Rumsfeld JS, Shah BR. 2017 Roadmap for Innovation—ACC Health Policy Statement on Healthcare Transformation in the Era of Digital Health, Big Data, and Precision Health A Report of the American College of Cardiology Task Force on Health Policy Statements and Systems of Care. Journal Of The American College Of Cardiology 2017, 70: 2696-2718. PMID: 29169478, DOI: 10.1016/j.jacc.2017.10.018.Peer-Reviewed Original ResearchMeSH KeywordsAdvisory CommitteesAmerican Heart AssociationBig DataCardiologyDiffusion of InnovationHealth PolicyHumansPrecision MedicineUnited States
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