2021
IRF8 is a Reliable Monoblast Marker for Acute Monocytic Leukemias
Katz SG, Edappallath S, Xu ML. IRF8 is a Reliable Monoblast Marker for Acute Monocytic Leukemias. The American Journal Of Surgical Pathology 2021, 45: 1391-1398. PMID: 34172624, DOI: 10.1097/pas.0000000000001765.Peer-Reviewed Original ResearchConceptsChronic myelomonocytic leukemiaAcute monocytic leukemiaBlast countCore biopsyMyelomonocytic leukemiaBone marrowPredictive valueMonocytic leukemiaBone marrow core biopsiesCases of AMoLMarrow core biopsiesAcute myeloid leukemia subtypesExpression of IRF8Acute myeloid leukemiaTrephine core biopsiesReliable surface markersDendritic cell progenitorsNegative predictive valuePositive predictive valuePotential biomarker candidatesBlast increaseMonocytic blastsUseful immunostainsBlast percentageReactive monocytosis
2017
Day 14 bone marrow examination in the management of acute myeloid leukemia
Terry CM, Shallis RM, Estey E, Lim SH. Day 14 bone marrow examination in the management of acute myeloid leukemia. American Journal Of Hematology 2017, 92: 1079-1084. PMID: 28612456, DOI: 10.1002/ajh.24818.Peer-Reviewed Original ResearchConceptsDay 14 bone marrowBlast cell countNational Comprehensive Cancer NetworkBone marrow examinationInduction therapyBone marrowCell countMarrow examinationSecond induction therapyLonger hospital stayTreatment-related mortalityComprehensive Cancer NetworkManagement of patientsBone marrow evaluationAcute myeloid leukemiaFurther chemotherapyComplete remissionHospital stayIntravenous antimicrobialsMarrow evaluationClinical trialsBlood productsMyeloid leukemiaHigh riskDay 28
2016
In utero cytomegalovirus infection and development of childhood acute lymphoblastic leukemia
Francis SS, Wallace AD, Wendt GA, Li L, Liu F, Riley LW, Kogan S, Walsh KM, de Smith AJ, Dahl GV, Ma X, Delwart E, Metayer C, Wiemels JL. In utero cytomegalovirus infection and development of childhood acute lymphoblastic leukemia. Blood 2016, 129: 1680-1684. PMID: 27979823, PMCID: PMC5364339, DOI: 10.1182/blood-2016-07-723148.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaCMV infectionCytomegalovirus infectionLymphoblastic leukemiaChildhood acute lymphoblastic leukemiaUtero cytomegalovirus infectionCongenital CMV infectionCommon childhood cancerActive viral transcriptionBone marrow specimensNon-Hispanic whitesTiming of infectionNewborn blood samplesEtiologic roleRisk factorsChildhood cancerHealthy controlsHigh prevalenceMarrow specimensLeukemia blastsBlood samplesPrenatal originEtiologic agentInfectionHispanic children
2012
A unique pattern of extranodal involvement in Korean adults with sporadic Burkitt lymphoma: a single center experience
Jang S, Yoon D, Kim S, Yoon S, Kim D, Park C, Huh J, Lee S, Lee D, Ryu J, Suh C. A unique pattern of extranodal involvement in Korean adults with sporadic Burkitt lymphoma: a single center experience. Annals Of Hematology 2012, 91: 1917-1922. PMID: 22864762, DOI: 10.1007/s00277-012-1531-1.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAdolescentAdultAgedAged, 80 and overBone Marrow ExaminationBone Marrow NeoplasmsBone NeoplasmsBurkitt LymphomaCohort StudiesFemaleFollow-Up StudiesGastrointestinal NeoplasmsHospitals, VeteransHumansMaleMiddle AgedNeoplasm StagingRepublic of KoreaRetrospective StudiesSurvival AnalysisTomography, X-Ray ComputedUrogenital NeoplasmsYoung AdultConceptsComplete response rateExtranodal involvementExtranodal sitesSporadic Burkitt lymphomaBurkitt's lymphomaClinical outcomesGenitourinary tractBone marrowTwo-year overall survival ratesResponse rateCentral nervous system involvementMore extranodal sitesNervous system involvementProgression-free survivalSingle-center cohortSingle-center experienceAsan Medical CenterOverall survival rateAdult Korean patientsNon-Hodgkin lymphomaBL patientsBaseline characteristicsOverall survivalCenter cohortCenter experience
2010
Bone marrow involvement in patients with posttransplant lymphoproliferative disorders: incidence and prognostic factors
Montanari F, O'Connor OA, Savage DG, Zain JM, Venkatraman S, McCormick EK, Crook MT, Tsao L, Sevilla DW, Bhagat G, Alobeid B. Bone marrow involvement in patients with posttransplant lymphoproliferative disorders: incidence and prognostic factors. Human Pathology 2010, 41: 1150-1158. PMID: 20381113, DOI: 10.1016/j.humpath.2009.11.016.Peer-Reviewed Original ResearchConceptsMonomorphic posttransplant lymphoproliferative disorderPosttransplant lymphoproliferative disorderBone marrow involvementPolymorphic posttransplant lymphoproliferative disordersDiffuse large B-cell lymphomaLarge B-cell lymphomaMarrow involvementLymphoproliferative disordersB-cell lymphomaSerologic parametersEpstein-Barr virus statusPosttransplant lymphoproliferative disorder patientsDe novo diffuse large B-cell lymphomaNovo diffuse large B-cell lymphomaBone marrow examinationElevated lactate dehydrogenaseBone marrow biopsyHodgkin lymphoma typeDiffuse large B-cell lymphoma casesLarge B-cell lymphoma casesB-cell lymphoma casesSensitive screening toolStaging biopsiesExtranodal involvementMarrow examination
2008
FDG PET/CT findings in acute adult mononucleosis mimicking malignant lymphoma
Lustberg M, Aras O, Meisenberg B. FDG PET/CT findings in acute adult mononucleosis mimicking malignant lymphoma. European Journal Of Haematology 2008, 81: 154-156. PMID: 18462255, DOI: 10.1111/j.1600-0609.2008.01088.x.Peer-Reviewed Original ResearchConceptsFDG positron emission tomographyPositron emission tomographyComputed tomographyMalignant lymphomaPET scansAcute Epstein-Barr virus infectionFDG PET/CT findingsFDG-PET/Computed TomographyEpstein-Barr virus infectionFalse-positive PET scansPET/CT findingsPET/Computed TomographyAcute EBV infectionPersistence of feverAcute infectious mononucleosisAbdominal computed tomographyBone marrow biopsyNon-malignant conditionsAdditional diagnostic workupLarge granular lymphocytesAvid FDG uptakeBroad-spectrum antibioticsAbnormal lymphadenopathyAcute sinusitisB symptomsCorrelation of MRI-Based bone marrow burden score with genotype and spleen status in Gaucher's disease.
DeMayo RF, Haims AH, McRae MC, Yang R, Mistry PK. Correlation of MRI-Based bone marrow burden score with genotype and spleen status in Gaucher's disease. American Journal Of Roentgenology 2008, 191: 115-23. PMID: 18562733, PMCID: PMC3731993, DOI: 10.2214/ajr.07.3550.Peer-Reviewed Original ResearchConceptsBone marrow burden scoreEnzyme replacement therapyBurden scoreBone marrow diseaseSpleen statusReplacement therapyGaucher diseaseN370S alleleCumulative durationPathologic findingsLiver volumeMarrow diseaseSignificant positive correlationBone marrow burdenCorrelation of MRIN370S homozygotesUntreated diseaseClinical parametersPositive correlationLiver sizeProtective roleAmeliorative effectSignificant associationGreater riskDiseaseScleroderma-Like Illness as a Presenting Feature of Multiple Myeloma and Amyloidosis
Reyes CM, Rudinskaya A, Kloss R, Girardi M, Lazova R. Scleroderma-Like Illness as a Presenting Feature of Multiple Myeloma and Amyloidosis. JCR Journal Of Clinical Rheumatology 2008, 14: 161-165. PMID: 18525436, DOI: 10.1097/rhu.0b013e3181775a15.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmyloidosisBence Jones ProteinBone Marrow ExaminationErythemaFemaleHistocytochemistryHumansMultiple MyelomaScleroderma, LocalizedConceptsMultiple myelomaLow-dose prednisoneOnly laboratory abnormalityRepeat skin biopsyPositive antinuclear antibodyMultiple lytic lesionsConnective tissue diseaseBence Jones proteinuriaBone marrow biopsyAntinuclear antibody testCarpal tunnel surgeryEcchymotic rashForearm lesionGeneralized arthralgiasPeriungual erythemaJoint symptomsLeukocytoclastic vasculitisMalar rashPresenting featuresSymmetric polyarthritisAntinuclear antibodiesLaboratory abnormalitiesRheumatologic evaluationHand painLytic lesions
2005
RAS mutation is associated with hyperdiploidy and parental characteristics in pediatric acute lymphoblastic leukemia
Wiemels JL, Zhang Y, Chang J, Zheng S, Metayer C, Zhang L, Smith MT, Ma X, Selvin S, Buffler PA, Wiencke JK. RAS mutation is associated with hyperdiploidy and parental characteristics in pediatric acute lymphoblastic leukemia. Leukemia 2005, 19: 415-419. PMID: 15674422, DOI: 10.1038/sj.leu.2403641.Peer-Reviewed Original ResearchConceptsRas mutationsMaternal ageLeukemia casesPediatric acute lymphoblastic leukemiaAcute lymphoblastic leukemia casesDiagnostic bone marrow samplesIncident leukemia casesPaternal preconception smokingNorthern California Childhood Leukemia StudyAcute lymphoblastic leukemiaLymphoblastic leukemia casesBone marrow samplesKRAS codon 12California Childhood Leukemia StudyRAS gene mutationsChildhood Leukemia StudyEtiology of subtypesPreconception smokingCase seriesLymphoblastic leukemiaLeukemia patientsMultivariable modelMarrow samplesHigh hyperdiploidyChildhood leukemia
2000
Pyoderma Gangrenosum and Myelodysplastic Syndrome
LITVAK D, KIRSNER R, PAKDAMAN N, FEDERMAN D. Pyoderma Gangrenosum and Myelodysplastic Syndrome. Southern Medical Journal 2000, 93: 923-925. PMID: 11005358, DOI: 10.1097/00007611-200009000-00019.Peer-Reviewed Original Research
1998
Morphologic, Immunophenotypic, and Molecular Evaluation of Bone Marrow Involvement in Non-Hodgkin's Lymphoma
Crotty P, Smith B, Tallini G. Morphologic, Immunophenotypic, and Molecular Evaluation of Bone Marrow Involvement in Non-Hodgkin's Lymphoma. Applied Immunohistochemistry & Molecular Morphology 1998, 7: 90-95. PMID: 9785007, DOI: 10.1097/00019606-199804000-00005.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, CDBiomarkers, TumorBone MarrowBone Marrow ExaminationClone CellsFlow CytometryGene Rearrangement, B-LymphocyteGene Rearrangement, T-LymphocyteHumansImmunophenotypingLymphoma, B-CellLymphoma, Non-HodgkinLymphoma, T-CellNeoplasm ProteinsNeoplastic Stem CellsPolymerase Chain ReactionSensitivity and SpecificityConceptsPrimer polymerase chain reactionMarrow involvementT-cell neoplasiaFlow cytometryB-cell neoplasiaObjective evidenceT-cell receptor gene rearrangementsBone marrow involvementConsensus primer polymerase chain reactionNon-Hodgkin lymphomaChronic lymphocytic leukemiaB-cell lymphomaT-cell neoplasmsB-cell neoplasmsReceptor gene rearrangementsDetection of clonalityDetectable diseaseHodgkin's lymphomaPolymerase chain reactionLymphocytic leukemiaApparent diseaseLymphomaPatientsImportant adjunctNeoplasia
1978
Sequential nonsurgical and surgical staging of non‐Hodgkin's lymphoma
Chabner B, Johnson R, Young R, Canellos G, Hubbard S, Johnson S, Devita V. Sequential nonsurgical and surgical staging of non‐Hodgkin's lymphoma. Cancer 1978, 42: 922-925. PMID: 150938, DOI: 10.1002/1097-0142(197808)42:2+<922::aid-cncr2820420714>3.0.co;2-9.Peer-Reviewed Original Research
1977
Characteristics of blast crisis in chronic granulocytic leukemia.
Rosenthal S, Canellos G, DeVita V, Gralnick H. Characteristics of blast crisis in chronic granulocytic leukemia. Blood 1977, 49: 705-14. PMID: 265737, DOI: 10.1182/blood.v49.5.705.bloodjournal495705.Peer-Reviewed Original ResearchConceptsChronic granulocytic leukemiaBlast crisisExtramedullary leukemiaGranulocytic leukemiaDiagnosis of blast crisisPh1-positive chronic granulocytic leukemiaLymphoblastic groupAcute leukemiaPeripheral bloodHematological criteriaHematological featuresBone marrowLeukemiaMorphological subgroupsPatientsThrombocytopeniaTerminal phaseMarrow
1975
In vitro granulocyte production in patients with Hodgkin's disease and lymphocytic, histiocytic, and mixed lymphomas.
Bull J, DeVita V, Carbone P. In vitro granulocyte production in patients with Hodgkin's disease and lymphocytic, histiocytic, and mixed lymphomas. Blood 1975, 45: 833-42. PMID: 1125431, DOI: 10.1182/blood.v45.6.833.bloodjournal456833.Peer-Reviewed Original ResearchConceptsHodgkin's diseaseMixed lymphomaUntreated patientsHistiocytic-lymphocytic lymphomasAdvanced Hodgkin's diseaseMOPP chemotherapyGranulocyte colony formationCombination chemotherapyMarrow culturesCFU-CIn vitro examinationLymphomaChemotherapyGranulocyte productionPatientsLong-term effectsAcute responseHodgkinColony formationDecreased numberDiseaseColony growthDibromomannitol in the treatment of chronic granulocytic leukemia: a prospective randomized comparison with busulfan.
Canellos G, Young R, Neiman P, DeVita V. Dibromomannitol in the treatment of chronic granulocytic leukemia: a prospective randomized comparison with busulfan. Blood 1975, 45: 197-203. PMID: 1054609, DOI: 10.1182/blood.v45.2.197.bloodjournal452197.Peer-Reviewed Original ResearchConceptsTreatment of chronic granulocytic leukemiaBusulfan-treated patientsChronic granulocytic leukemiaGranulocytic leukemiaMedian duration of disease controlChronic phase of CGLDuration of disease controlContinuous maintenance therapyElevated leukocyte countTreated with busulfanIncreased skin pigmentationMyelosuppressive actionRemission inductionMaintenance therapyMedian survivalMedian durationBlastic transformationPulmonary fibrosisBusulfanRandomized comparisonChronic phaseLeukocyte countDibromomannitolPatientsCytological dysplasia
1974
Thrombocytosis in Chronic Granulocytic Leukemia: Incidence and Clinical Significance
Mason J, DeVita V, Canellos G. Thrombocytosis in Chronic Granulocytic Leukemia: Incidence and Clinical Significance. Blood 1974, 44: 483-487. PMID: 4528824, DOI: 10.1182/blood.v44.4.483.483.Peer-Reviewed Original ResearchConceptsChronic granulocytic leukemiaPlatelet countGranulocytic leukemiaClinical significanceOccurrence of thrombocytosisElevated platelet countThrombohemorrhagic complicationsUntreated patientsMedian durationShorter survivalBlastic crisisNormal countsPatientsSubsequent courseThrombocytosisLeukemiaCountEntire courseGroupCourseComplicationsClinicIncidenceDiagnosis
1971
Hematologic and Cytogenetic Remission of Blastic Transformation in Chronic Granulocytic Leukemia
Canellos G, DeVita V, Whang-Peng J, Carbone P. Hematologic and Cytogenetic Remission of Blastic Transformation in Chronic Granulocytic Leukemia. Blood 1971, 38: 671-679. PMID: 5288508, DOI: 10.1182/blood.v38.6.671.671.Peer-Reviewed Original ResearchConceptsChronic granulocytic leukemiaBlastic phaseChronic phaseGranulocytic leukemiaBlastic transformationGood partial remissionComplete hematologic remissionCombination of vincristineCell linesResistant cell linesComplete remissionHematologic remissionPartial remissionCytogenetic remissionSubsequent relapseRemissionPatientsFavorable responseDisease
1969
Familial chronic lymphocytic leukemia.
FRAUMENI J, VOGEL C, DEVITA V. Familial chronic lymphocytic leukemia. Annals Of Internal Medicine 1969, 71: 279-84. PMID: 4184386, DOI: 10.7326/0003-4819-71-2-279.Peer-Reviewed Original Research
1968
Bone-Marrow Biopsy in Hodgkin's Disease
Bennett J, Gralnick H, Devita V. Bone-Marrow Biopsy in Hodgkin's Disease. New England Journal Of Medicine 1968, 278: 1179. PMID: 5646722, DOI: 10.1056/nejm196805232782120.Peer-Reviewed Original Research
1965
Tocopherol Deficiency in Man
Binder H, Herting D, Hurst V, Finch S, Spiro H. Tocopherol Deficiency in Man. New England Journal Of Medicine 1965, 273: 1289-1297. PMID: 5852452, DOI: 10.1056/nejm196512092732401.Peer-Reviewed Original Research
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