2025
Investigating practice patterns in bone marrow biopsies for cutaneous T-cell lymphoma: A multicenter clinician survey.
Rashid S, Kim E, Slavinsky V, Sun Y, Pierog O, Gru A, Foss F, Rozati S. Investigating practice patterns in bone marrow biopsies for cutaneous T-cell lymphoma: A multicenter clinician survey. Journal Of Clinical Oncology 2025, 43 DOI: 10.1200/jco.2025.43.16_suppl.e19075.Peer-Reviewed Original ResearchCutaneous T-cell lymphomaBone marrow biopsyT-cell lymphomaMarrow biopsyManagement of cutaneous T-cell lymphomaPrognosis of cutaneous T-cell lymphomaBone marrow biopsy findingsPractice patternsAdvanced disease stageFisher's exact testUnexplained hematologic abnormalitiesInvestigate practice patternsEvidence-based guidelinesPET-CTStaging purposesExtracutaneous involvementPrognostic implicationsT cellsHematologic abnormalitiesSystem involvementAltered managementDifferential diagnosisExact testDisease stagePatient management
2024
A-273 Clinician Practice Patterns and Recommendations for Bone Marrow Biopsy in Cutaneous T-Cell Lymphoma
Slavinsky V, Pierog O, Weiner J, Gru A, Foss F, Rozati S. A-273 Clinician Practice Patterns and Recommendations for Bone Marrow Biopsy in Cutaneous T-Cell Lymphoma. European Journal Of Cancer 2024, 211: 114437. DOI: 10.1016/j.ejca.2024.114437.Peer-Reviewed Original Research
2021
The Lab as a Driver of Quality in the Preanalytical Realm: The Case of Technologist-Assisted Bone Marrow Biopsies
Siddon AJ, Kroft SH. The Lab as a Driver of Quality in the Preanalytical Realm: The Case of Technologist-Assisted Bone Marrow Biopsies. American Journal Of Clinical Pathology 2021, 157: 480-481. PMID: 34788363, DOI: 10.1093/ajcp/aqab180.Peer-Reviewed Original ResearchHistopathologic and Machine Deep Learning Criteria to Predict Lymphoma Transformation in Bone Marrow Biopsies.
Irshaid L, Bleiberg J, Weinberger E, Garritano J, Shallis RM, Patsenker J, Lindenbaum O, Kluger Y, Katz SG, Xu ML. Histopathologic and Machine Deep Learning Criteria to Predict Lymphoma Transformation in Bone Marrow Biopsies. Archives Of Pathology & Laboratory Medicine 2021, 146: 182-193. PMID: 34086849, DOI: 10.5858/arpa.2020-0510-oa.Peer-Reviewed Original ResearchConceptsLarge cell transformationChronic lymphocytic leukemiaBone marrow biopsyMarrow biopsyFollicular lymphomaIndolent B-cell lymphomaLarge lymphoma cellsClinical disease progressionDiagnosis of FLFinal outcome dataB-cell lymphomaLarge tumor cellsEase of procedureAggressive chemotherapyLow morbidityLymph nodesWorse prognosisWhole slide scansHistologic findingsPatient's probabilityDisease progressionLymphocytic leukemiaLymphoma transformationClinical questionsOutcome data
2019
Rationale for Targeting BCL6 in MLL-Rearranged B-ALL
Chan L, Hurtz C, Geng H, Ballabio E, Xiao G, Deb G, Khoury H, Armstrong S, Ernst P, Melnick A, Milne T, Müschen M. Rationale for Targeting BCL6 in MLL-Rearranged B-ALL. Blood 2019, 134: 1239. DOI: 10.1182/blood-2019-131565.Peer-Reviewed Original ResearchB-cell acute lymphoblastic leukemiaPharmacological inhibitionABT-199Group of patientsBCL6 expressionBone marrow biopsyPoor clinical outcomeAcute lymphoblastic leukemiaBCL2 inhibitor ABT-199BH3 mimetic ABT-199MLL gene rearrangementTransplant recipient miceMLL fusionsB-cell transformationClinical outcomesMarrow biopsyTreatment of MLLDismal outcomeLymphoblastic leukemiaRecipient miceNormal B cell developmentSelective vulnerabilityImmunohistochemical stainingInfant BSmall molecule inhibitorsRationale for targeting BCL6 in MLL-rearranged acute lymphoblastic leukemia
Hurtz C, Chan LN, Geng H, Ballabio E, Xiao G, Deb G, Khoury H, Chen CW, Armstrong SA, Chen J, Ernst P, Melnick A, Milne T, Müschen M. Rationale for targeting BCL6 in MLL-rearranged acute lymphoblastic leukemia. Genes & Development 2019, 33: 1265-1279. PMID: 31395741, PMCID: PMC6719625, DOI: 10.1101/gad.327593.119.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkers, TumorCell SurvivalCells, CulturedGene DeletionGene Expression Regulation, LeukemicGene TargetingHumansMiceMyeloid-Lymphoid Leukemia ProteinOncogene Proteins, FusionPrecursor Cell Lymphoblastic Leukemia-LymphomaPrognosisPromoter Regions, GeneticProto-Oncogene Proteins c-bcl-6ConceptsB-cell acute lymphoblastic leukemiaAcute lymphoblastic leukemiaLymphoblastic leukemiaPharmacological inhibitionGroup of patientsBCL6 expressionBone marrow biopsyBH3 mimetic ABT-199Transplant recipient miceMLL fusionsB-cell transformationMarrow biopsyTreatment of MLLDismal outcomeRecipient miceNormal B cell developmentImmunohistochemical stainingTranscriptional activationB cell developmentMalignant transformationDrug resistanceGenetic deletionPatient samplesExpression of BimMLL-ENL fusion
2018
A rare case of visceral leishmaniasis in an immunocompetent traveler returning to the United States from Europe
Haque L, Villanueva M, Russo A, Yuan Y, Lee EJ, Topal J, Podoltsev N. A rare case of visceral leishmaniasis in an immunocompetent traveler returning to the United States from Europe. PLOS Neglected Tropical Diseases 2018, 12: e0006727. PMID: 30286207, PMCID: PMC6171829, DOI: 10.1371/journal.pntd.0006727.Peer-Reviewed Case Reports and Technical NotesConceptsVisceral leishmaniasisHealthy travelersRare caseEndemic areasEndemic visceral leishmaniasisSuccessful initial treatmentLiposomal amphotericin BBone marrow biopsyImmunocompetent adultsImmunocompetent travelersNight sweatsImmunocompetent individualsInitial treatmentMarrow biopsyRelapseAmphotericin BPreventive measuresLeishmaniasisTreatmentUnited StatesExtensive experiencePancytopeniaSplenomegalyBiopsyPatients
2016
Wide variations in blood product transfusion practices among providers who care for patients with acute leukemia in the United States
Pine AB, Lee E, Sekeres M, Steensma DP, Zelterman D, Prebet T, DeZern A, Komrokji R, Litzow M, Luger S, Stone R, Erba HP, Garcia‐Manero G, Lee AI, Podoltsev NA, Barbarotta L, Kasberg S, Hendrickson JE, Gore SD, Zeidan AM. Wide variations in blood product transfusion practices among providers who care for patients with acute leukemia in the United States. Transfusion 2016, 57: 289-295. PMID: 27878822, PMCID: PMC5309168, DOI: 10.1111/trf.13934.Peer-Reviewed Original ResearchConceptsAcute leukemiaTransfusion practiceBlood productsTransfusion patternsAL patientsHigh-quality trial evidenceBlood product transfusionBone marrow biopsyEvidence-based guidelinesClinical outcome dataRed blood cell productsBlood cell productsTransfusion goalsProduct transfusionTransfusion triggerUnnecessary transfusionsAmbulatory patientsCryoprecipitate transfusionMarrow biopsyTrial evidenceLumbar punctureSupportive managementCare settingsInvasive proceduresOutcome dataSynchronous rectal adenocarcinoma and splenic marginal zone lymphoma
Srikumar T, Markow M, Centeno B, Hoffe S, Tao J, Fernandez H, Strosberg J, Shibata D. Synchronous rectal adenocarcinoma and splenic marginal zone lymphoma. Current Oncology 2016, 23: 70-74. PMID: 26966416, PMCID: PMC4754072, DOI: 10.3747/co.23.2711.Peer-Reviewed Original ResearchMarginal zone lymphomaSplenic marginal zone lymphomaRectal adenocarcinomaMassive splenomegalyExternal beam radiation therapyAdjuvant FOLFOX chemotherapyDifferent primary originsEn bloc splenectomySynchronous rectal adenocarcinomaLow anterior resectionAdvanced rectal cancerBone marrow biopsyComplete blood countComputed tomography (CT) imagingFOLFOX chemotherapyPelvic radiationStage T3N1M0Abdominal painAnterior resectionDistal pancreatectomySynchronous cancersConcomitant diagnosisRectal cancerClinical presentationMarrow biopsy
2014
Testicular Myeloid Sarcoma: A Rare Manifestation of Acute Myeloid Leukemia in an Infant
Tran CN, Collie AM, Flagg A, Rhee A. Testicular Myeloid Sarcoma: A Rare Manifestation of Acute Myeloid Leukemia in an Infant. Urology 2014, 84: 925-927. PMID: 25260454, DOI: 10.1016/j.urology.2014.07.005.Peer-Reviewed Case Reports and Technical NotesConceptsAcute myeloid leukemiaMyeloid sarcomaMyeloid leukemiaAllogeneic bone marrow transplantationLocal radiation therapyBilateral testicular massesRadical inguinal orchiectomyBone marrow transplantationBone marrow biopsyPainless scrotal swellingBone marrow diseaseInduction chemotherapyInguinal orchiectomyRare manifestationMarrow transplantationMarrow biopsyScrotal swellingMarrow diseaseRadiation therapyTesticular massSurgical pathologySarcomaLeukemiaSeparate entitiesRemission
2013
Primary Marrow-Derived Stromal Cells: Isolation and Manipulation
Ramakrishnan A, Torok-Storb B, Pillai M. Primary Marrow-Derived Stromal Cells: Isolation and Manipulation. Methods In Molecular Biology 2013, 1035: 75-101. PMID: 23959984, PMCID: PMC3748384, DOI: 10.1007/978-1-62703-508-8_8.Peer-Reviewed Original ResearchConceptsMarrow stromal cellsStem cellsMSC populationsPrimary marrow stromal cellsMultipotent stem cellsImmortalized cell linesStromal cellsPrimary marrowMesenchymal lineagesCellular heterogeneityMesenchymal stem cellsHematopoietic cellsCell linesRare cellsCellsBone marrow mononuclear cellsMarrow mononuclear cellsBone marrow harvestLineagesBone marrowMarrow biopsyMononuclear cellsClinical transplantationMarrow harvestPopulation
2010
Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells
Dutt S, Narla A, Lin K, Mullally A, Abayasekara N, Megerdichian C, Wilson FH, Currie T, Khanna-Gupta A, Berliner N, Kutok JL, Ebert BL. Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells. Blood 2010, 117: 2567-2576. PMID: 21068437, PMCID: PMC3062351, DOI: 10.1182/blood-2010-07-295238.Peer-Reviewed Original ResearchMeSH KeywordsAnemia, Diamond-BlackfanAnemia, MacrocyticAnimalsBenzothiazolesCell CycleCell LineageCell NucleolusChromosome DeletionChromosomes, Human, Pair 5Cyclin-Dependent Kinase Inhibitor p21Erythroid Precursor CellsHaploinsufficiencyHematopoiesisHumansImidazolesMiceMice, Inbred BALB CMyelodysplastic SyndromesPiperazinesProtein BindingProto-Oncogene Proteins c-mdm2Ribosomal ProteinsRNA, Small InterferingTolueneTumor Suppressor Protein p53ConceptsErythroid progenitor cellsDiamond-Blackfan anemiaMyelodysplastic syndromeProgenitor cellsInduction of p53Bone marrow biopsyErythroid lineageNuclear p53 stainingFailure of erythropoiesisBone marrow failureHuman erythroid progenitor cellsMarrow biopsyHematopoietic progenitor cellsP53 stainingHuman hematopoietic progenitor cellsCell cycle arrestPharmacologic inhibitionMarrow failureNutlin-3Consequent cell cycle arrestP53 pathwayCycle arrestSelective impairmentExpression of shRNAsP53
2006
Preliminary results of a randomized placebo-controlled double-blind trial of weekly docetaxel combined with imatinib in men with metastatic androgen-independent prostate cancer (AIPC) and bone metastases (BM)
Mathew P, Thall P, Johnson M, Oh W, Meluch A, Morris M, Troncoso P, Bucana C, Fidler I, Logothetis C. Preliminary results of a randomized placebo-controlled double-blind trial of weekly docetaxel combined with imatinib in men with metastatic androgen-independent prostate cancer (AIPC) and bone metastases (BM). Journal Of Clinical Oncology 2006, 24: 4562-4562. DOI: 10.1200/jco.2006.24.18_suppl.4562.Peer-Reviewed Original ResearchAndrogen-independent prostate cancerTime to progressionBone metastasesPlatelet-derived growth factor receptorPartial responseProgressive androgen-independent prostate cancerMetastatic androgen-independent prostate cancerHigh-dose steroid useMedian time to progressionRandomized placebo-controlled double-blind trialGrade 3 AEsMedian overall survivalBone marrow biopsyECOG performance scoreGastrointestinal adverse eventsPerforated sigmoid diverticulitisGrowth factor receptorPerformance scoresWeekly docetaxelProgression-FreeStable diseaseMarrow biopsyTumor responseSigmoid diverticulitisDocetaxel activity
2003
Denileukin Diftitox and Hyper-CVAD in the Treatment Human T-Cell Lymphotropic Virus 1–Associated Adult T-Cell Leukemia/Lymphoma
DiVenuti G, Nawgiri R, Foss F. Denileukin Diftitox and Hyper-CVAD in the Treatment Human T-Cell Lymphotropic Virus 1–Associated Adult T-Cell Leukemia/Lymphoma. Clinical Lymphoma Myeloma & Leukemia 2003, 4: 176-178. PMID: 14715100, DOI: 10.3816/clm.2003.n.027.Peer-Reviewed Original ResearchConceptsAdult T-cell leukemia/lymphomaT-cell leukemia/lymphomaDenileukin diftitoxLeukemia/lymphomaClinical remissionHuman T-cell lymphotropic virus-1Human T-cell lymphotropic virusCell leukemia/lymphomaBone marrow myelofibrosisComplete clinical remissionBone marrow biopsyLymphotropic virus-1Acute T-cell leukemiaNormal hematopoiesisT-cell leukemiaLeukemic T cellsExtensive myelofibrosisHyper-CVADInitial therapyMaintenance therapyClinical improvementClinical manifestationsMarrow biopsyDisease progressionT cells
2000
Pyoderma Gangrenosum and Myelodysplastic Syndrome
LITVAK D, KIRSNER R, PAKDAMAN N, FEDERMAN D. Pyoderma Gangrenosum and Myelodysplastic Syndrome. Southern Medical Journal 2000, 93: 923-925. PMID: 11005358, DOI: 10.1097/00007611-200009000-00019.Peer-Reviewed Original ResearchPyoderma Gangrenosum and Myelodysplastic Syndrome
LITVAK D, KIRSNER R, PAKDAMAN N, FEDERMAN D. Pyoderma Gangrenosum and Myelodysplastic Syndrome. Southern Medical Journal 2000, 93: 923-925. DOI: 10.1097/00007611-200093090-00019.Peer-Reviewed Original ResearchPrimary cutaneous follicle center cell lymphoma with follicular growth pattern
Cerroni L, Arzberger E, Puütz B, Hoüfler G, Metze D, Sander C, Rose C, Wolf P, Ruütten A, McNiff J, Kerl H. Primary cutaneous follicle center cell lymphoma with follicular growth pattern. Blood 2000, 95: 3922-3928. PMID: 10845929, DOI: 10.1182/blood.v95.12.3922.Peer-Reviewed Original ResearchConceptsB-cell infiltratesFollicular growth patternGerminal centersPrimary cutaneous follicle center cell lymphomaCutaneous follicle center cell lymphomaPrimary cutaneous follicular lymphomaCutaneous B-cell lymphomaCutaneous follicular lymphomaSame monoclonal populationFollicle center cell lymphomaCutaneous B-cell infiltratesBone marrow biopsyReactive germinal centersB-cell lymphomaFollicle center cellsBcl-2 protein expressionExtracutaneous spreadStaging investigationsPolymerase chain reaction analysisMarrow biopsyImmunophenotypic criteriaNeoplastic folliclesFollicular patternMonoclonal rearrangementSkin lesionsPrimary cutaneous follicle center cell lymphoma with follicular growth pattern
Cerroni L, Arzberger E, Pütz B, Höfler G, Metze D, Sander C, Rose C, Wolf P, Rütten A, McNiff J, Kerl H. Primary cutaneous follicle center cell lymphoma with follicular growth pattern. Blood 2000, 95: 3922-3928. DOI: 10.1182/blood.v95.12.3922.012k08_3922_3928.Peer-Reviewed Original ResearchB-cell infiltratesFollicular growth patternGerminal centersPrimary cutaneous follicle center cell lymphomaCutaneous follicle center cell lymphomaPrimary cutaneous follicular lymphomaCutaneous B-cell lymphomaCutaneous follicular lymphomaSame monoclonal populationFollicle center cell lymphomaCutaneous B-cell infiltratesBone marrow biopsyReactive germinal centersB-cell lymphomaFollicle center cellsBcl-2 protein expressionExtracutaneous spreadStaging investigationsPolymerase chain reaction analysisMarrow biopsyImmunophenotypic criteriaNeoplastic folliclesFollicular patternMonoclonal rearrangementSkin lesionsFulminant parvovirus infection following erythropoietin treatment in a patient with acquired immunodeficiency syndrome.
Borkowski J, Amrikachi M, Hudnall S. Fulminant parvovirus infection following erythropoietin treatment in a patient with acquired immunodeficiency syndrome. Archives Of Pathology & Laboratory Medicine 2000, 124: 441-5. PMID: 10705404, DOI: 10.5858/2000-124-0441-fpifet.Peer-Reviewed Original ResearchConceptsAcquired Immunodeficiency SyndromeBone marrow biopsyChronic anemiaImmunodeficiency syndromeMarrow biopsyReticulocyte responseParvovirus infectionErythroid aplasiaSecond bone marrow biopsyHuman parvovirus infectionSevere chronic anemiaIntravenous immunoglobulinErythropoietin treatmentErythroid hyperplasiaErythropoietin administrationRapid correctionHistologic examinationAnemiaInfectious naturePatientsInfectionBiopsyAplasiaSyndromeBlack men
1987
Histopathology of bone marrow in human immunodeficiency virus infXection
Delacrétaz F, Perey L, Schmidt P, Chave J, Costa J. Histopathology of bone marrow in human immunodeficiency virus infXection. Virchows Archiv A Pathological Anatomy And Histopathology 1987, 411: 543-551. PMID: 3118563, DOI: 10.1007/bf00713285.Peer-Reviewed Original ResearchConceptsHIV infectionMyelodysplastic featuresHistological featuresHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionBone marrow findingsBone marrow biopsyMarrow findingsMarrow biopsyHaematological abnormalitiesGelatinous transformationVirus infectionHaematological findingsPatientsBone marrowConspicuous findingInfectionCell linesFindingsCytopaeniaPlasmacytosisLymphocytosisBiopsyMyelodysplasiaHypercellularity
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply