2020
Smooth Muscle Cell Reprogramming in Aortic Aneurysms
Chen PY, Qin L, Li G, Malagon-Lopez J, Wang Z, Bergaya S, Gujja S, Caulk AW, Murtada SI, Zhang X, Zhuang ZW, Rao DA, Wang G, Tobiasova Z, Jiang B, Montgomery RR, Sun L, Sun H, Fisher EA, Gulcher JR, Fernandez-Hernando C, Humphrey JD, Tellides G, Chittenden TW, Simons M. Smooth Muscle Cell Reprogramming in Aortic Aneurysms. Cell Stem Cell 2020, 26: 542-557.e11. PMID: 32243809, PMCID: PMC7182079, DOI: 10.1016/j.stem.2020.02.013.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsAortic aneurysmAneurysm developmentMedial smooth muscle cellsAortic aneurysm developmentContractile smooth muscle cellsGrowth factor βHypercholesterolemic dietSmooth muscleAortic wallMesenchymal stem cellsMuscle cellsAneurysmsMarked increaseFactor βExuberant growthStem cellsHuman diseasesCell massCellsAtherosclerosisHypercholesterolemiaInflammationAortaApoE
2019
Medial artery calcification increases neointimal hyperplasia after balloon injury
Marshall AP, Luo W, Wang XL, Lin T, Cai Y, Guzman RJ. Medial artery calcification increases neointimal hyperplasia after balloon injury. Scientific Reports 2019, 9: 8193. PMID: 31160618, PMCID: PMC6547750, DOI: 10.1038/s41598-019-44668-4.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, BalloonAnimalsBone Morphogenetic Protein 2CalcinosisCalcium ChlorideCarotid ArteriesCarotid Artery InjuriesCell ProliferationCoronary RestenosisDisease Models, AnimalHyperplasiaMaleMuscle, Smooth, VascularMyocytes, Smooth MuscleNeointimaProliferating Cell Nuclear AntigenRatsRats, Sprague-DawleyTunica IntimaConceptsSmooth muscle cellsNeointimal hyperplasiaBalloon injuryArterial calcificationCalcified arteriesMedial smooth muscle cellsCell nuclear antigen stainingBalloon catheter injuryMedial artery calcificationTime of injuryVascular smooth muscle cellsNeointimal cell proliferationCell proliferationCatheter injuryArtery calcificationMedial calcificationSubcutaneous injectionAntigen stainingVitamin D3Rat carotidEffect of calcificationArteryHyperplasiaAdventitial applicationInjury
2014
Myh 11 R 247 C / R 247 C mutations increase thoracic aorta vulnerability to intramural damage despite a general biomechanical adaptivity
Bellini C, Wang S, Milewicz DM, Humphrey JD. Myh 11 R 247 C / R 247 C mutations increase thoracic aorta vulnerability to intramural damage despite a general biomechanical adaptivity. Journal Of Biomechanics 2014, 48: 113-121. PMID: 25433566, PMCID: PMC4283495, DOI: 10.1016/j.jbiomech.2014.10.031.Peer-Reviewed Original ResearchConceptsThoracic aortaSevere vascular phenotypeAortic aneurysmContractile proteinsLocalized poolsMedial smooth muscle cellsEpigenetic factorsGenetic studiesThoracic aortic diseaseThoracic aortic aneurysmSmooth muscle cellsSuch mutationsMutationsC mutationAortic dissectionAortic diseaseHistopathologic characteristicsMuscle cellsRisk factorsGlycosaminoglycans/proteoglycansNormal adaptationMouse modelNormal biomechanicsAortic structureAorta
2011
Transforming Growth Factor Beta Expression by Human Vascular Cells Inhibits Interferon Gamma Production and Arterial Media Injury by Alloreactive Memory T Cells
Lebastchi AH, Khan SF, Qin L, Li W, Zhou J, Hibino N, Yi T, Rao DA, Pober JS, Tellides G. Transforming Growth Factor Beta Expression by Human Vascular Cells Inhibits Interferon Gamma Production and Arterial Media Injury by Alloreactive Memory T Cells. American Journal Of Transplantation 2011, 11: 2332-2341. PMID: 21812925, PMCID: PMC3203343, DOI: 10.1111/j.1600-6143.2011.03676.x.Peer-Reviewed Original ResearchConceptsEffector T cellsMemory T cellsNaïve T cellsT cellsIL-17Vascular cellsEffector memory T cellsAlloreactive memory T cellsGrowth factor-beta expressionMedial smooth muscle cellsHuman effector memory T cellsHuman coronary artery graftsIL-17 productionCoronary artery graftsIFN-γ productionAllogeneic endothelial cellsInterferon-gamma productionDevelopment of arteriosclerosisExpression of TGFRole of TGFSmooth muscle cellsImmunodeficient mouse hostsHuman T cellsIntimal compartmentMedial infiltration
1997
Rat arterial wall retains myointimal hyperplastic potential long after arterial injury.
Sirois M, Simons M, Kuter D, Rosenberg R, Edelman E. Rat arterial wall retains myointimal hyperplastic potential long after arterial injury. Circulation 1997, 96: 1291-8. PMID: 9286961, DOI: 10.1161/01.cir.96.4.1291.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsVascular diseaseNeointimal hyperplasiaMuscle cellsMedial smooth muscle cellsBlood vesselsAccelerated vascular diseaseSingle-dose therapyPDGFR-beta expressionVascular smooth muscle cellsPlatelet-derived growth factorProliferative vascular diseasesPeriod of thrombocytopeniaArterial injuryEndothelial denudationVascular injuryPlatelet depletionIntimal hyperplasiaPharmacological modalitiesVascular healingArterial wallHyperplasiaGrowth factorNative vesselsInjury
1992
Interactions of Matrix Components and Soluble Factors in Vascular Responses to Injury
Madri J, Merwin J, Bell L, Basson C, Kocher O, Perlmutter R, Prinz C. Interactions of Matrix Components and Soluble Factors in Vascular Responses to Injury. 1992, 11-30. DOI: 10.1007/978-1-4899-0721-9_2.Peer-Reviewed Original ResearchSmooth muscle cellsMuscle cellsEndothelial cellsMatrix componentsSheet migrationWall integrityLarge vessel endothelial cellsExtracellular matrixVessel wall integrityVascular cellsVessel endothelial cellsActive endothelial cellsMetabolic activityMicrovascular endothelial cellsInterstitial stromaMedial smooth muscle cellsCellsDenudation injuryClose association
1990
Influence of the angiotensin system on endothelial and smooth muscle cell migration.
Bell L, Madri J. Influence of the angiotensin system on endothelial and smooth muscle cell migration. American Journal Of Pathology 1990, 137: 7-12. PMID: 2164777, PMCID: PMC1877705.Peer-Reviewed Original ResearchConceptsSmooth muscle cell migrationVessel wall responseMuscle cell migrationBovine aortic endothelial cellsAortic smooth muscle cell migrationMedial smooth muscle cellsEndothelial cellsAngiotensin system componentsIle8-angiotensin IIEnzyme inhibitor lisinoprilSmooth muscle cellsCell migrationAortic endothelial cellsAngiotensin systemAngiotensin-converting enzyme inhibitor lisinoprilInhibitor lisinoprilLuminal sizeVessel functionMuscle cellsCell monolayersInjuryCultured cell monolayersPresent studyImportant determinantCells
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply