2025
A systematic review of anti-suicidal effects of sedative-hypnotics and cognitive behavioral therapy for insomnia
Valentino K, Teopiz K, Wong S, Le G, Badulescu S, Johnson D, Ho R, Rhee T, Cao B, Rosenblat J, Mansur R, McIntyre R. A systematic review of anti-suicidal effects of sedative-hypnotics and cognitive behavioral therapy for insomnia. CNS Spectrums 2025, 30: e45. PMID: 40452498, DOI: 10.1017/s1092852925000318.Peer-Reviewed Original ResearchConceptsColumbia-Suicide Severity Rating ScaleOrexin receptor antagonistsScale for Suicide IdeationCognitive behavioral therapySuicidal ideationCBT-ISedative-hypnoticsBehavioral therapySuicide completersSuicide attemptsReducing depressive symptom severityEffects of sedative-hypnoticsDepressive symptom severityMeasures of suicidalitySeverity Rating ScaleRisk of suicideSleep-related interventionsAssociated with reduced SIComorbid insomniaSuicidal thoughtsSymptom severityRandomized Controlled TrialsTreating insomniaRating ScaleSleep interventionsThe association between cannabis use and suicidal intensity in psychiatric inpatients
Oladunjoye A, Swann A, Kosten T, Patriquin M, Bigdeli T, Barr P, Wilkinson A, Harding M, Nielsen D, Graham D. The association between cannabis use and suicidal intensity in psychiatric inpatients. American Journal On Addictions 2025, 34: 506-516. PMID: 40349103, DOI: 10.1111/ajad.70047.Peer-Reviewed Original ResearchSuicidal ideation intensityCannabis usePsychiatric inpatientsPsychological flexibilityColumbia-Suicide Severity Rating ScaleAssociated with cannabis useSuicidal intensityMale psychiatric inpatientsSubstance Involvement Screening TestSeverity Rating ScaleModel of moderationEmotion regulationPsychiatric comorbidityPolygenic risk scoresPath analysis modelSuicidal ideationSuicide attemptsRating ScaleSex-specific patternsPotential mediatorsSuicideInpatientsAssociated with greater riskCannabisAdolescentsLong-Term Safety and Efficacy of Esmethadone in Patients With Major Depressive Disorder: Findings From a 12-Month Open-Label Study.
Fava M, Pani L, De Martin S, Cutler A, Gorodetzky C, Vocci F, Sapienza F, Kosten T, Kröger C, Champasa P, Guidetti C, Comai S, Mattarei A, Folli F, Bushnell D, Traversa S, Inturrisi C, Manfredi P, Pappagallo M. Long-Term Safety and Efficacy of Esmethadone in Patients With Major Depressive Disorder: Findings From a 12-Month Open-Label Study. The Journal Of Clinical Psychiatry 2025, 86 PMID: 39999772, DOI: 10.4088/jcp.24m15438.Peer-Reviewed Original ResearchConceptsDepressive disorderColumbia-Suicide Severity Rating ScaleOpen-label studyDSM-5</i> criteriaFull analysis setMajor depressive disorderMeasures of depressionSeverity Rating ScaleSexual adverse eventsAntidepressant efficacyTreatment-emergent adverse eventsPostbaseline efficacy assessmentAdverse eventsSuicide attemptsUncompetitive antagonistCognitive functionSafety populationEfficacy assessmentRating ScaleEfficacy measuresMDDDouble-blind studyEmergent adverse eventsLong-term treatmentTreatment-related treatment-emergent adverse events
2024
Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder
Bigdeli T, Barr P, Rajeevan N, Graham D, Li Y, Meyers J, Gorman B, Peterson R, Sayward F, Radhakrishnan K, Natarajan S, Nielsen D, Wilkinson A, Malhotra A, Zhao H, Brophy M, Shi Y, O’Leary T, Gleason T, Przygodzki R, Pyarajan S, Muralidhar S, Gaziano J, Huang G, Concato J, Siever L, DeLisi L, Kimbrel N, Beckham J, Swann A, Kosten T, Fanous A, Aslan M, Harvey P. Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder. Molecular Psychiatry 2024, 29: 2399-2407. PMID: 38491344, DOI: 10.1038/s41380-024-02472-1.Peer-Reviewed Original ResearchBipolar I disorderSuicidal behaviorElectronic health recordsPolygenic scoresVeterans Health AdministrationSelf-reported SBColumbia-Suicide Severity Rating ScaleBipolar I disorder patientsCorrelates of suicidal behaviorClasses of psychotropic medicationsSelf-injurious behaviorHealth recordsSeverity Rating ScaleDiagnosed mental illnessAssociated with clinical variablesElectronic health record codesEHR domainDepressive disorderC-SSRSLifetime diagnosisSubstance-relatedPsychotropic medicationsSuicidal ideationExternalizing behaviorsSuicide attemptsMental health outcomes in patients with moderate to severe psoriasis treated with bimekizumab: Analysis of phase 2/3 randomized trials
Blauvelt A, Armstrong A, Merola J, Strober B, de Cuyper D, Peterson L, Davies O, Stark J, Lebwohl M. Mental health outcomes in patients with moderate to severe psoriasis treated with bimekizumab: Analysis of phase 2/3 randomized trials. Journal Of The American Academy Of Dermatology 2024, 91: 72-81. PMID: 38447700, DOI: 10.1016/j.jaad.2024.02.039.Peer-Reviewed Original ResearchModerate to severe psoriasisColumbia-Suicide Severity Rating ScaleSevere psoriasisIncreased risk of suicidal ideationRisk of suicidal ideationModerate to severe plaque psoriasisClinical trialsSeverity Rating ScaleFood and Drug Administration approvalRating scale responsesGeneral psoriasis populationPsoriasis patient populationPatient Health Questionnaire-9Placebo-treated patientsSevere plaque psoriasisMental health outcomesMental health changesPhase 2/3 trialsEuropean Medicines Agency approvalInterleukin (IL)-17ADrug Administration approvalPatient Health Questionnaire-9 scoresSuicidal ideationMeasure depressionRating Scale
2023
Development and interobserver reliability of a rating scale for lung ultrasound pathology in lower respiratory tract infection
Baloescu C, Chen A, Schnittke N, Hicks B, Zhu M, Kaili M, Shupp J, Chan D, Malia L, Coneybeare D, Gregory K, Kessler D, Raju B, Moore C. Development and interobserver reliability of a rating scale for lung ultrasound pathology in lower respiratory tract infection. WFUMB Ultrasound Open 2023, 1: 100006. DOI: 10.1016/j.wfumbo.2023.100006.Peer-Reviewed Original ResearchLower respiratory tract infectionsRespiratory tract infectionsIntraclass correlation coefficientTract infectionsUltrasound pathologiesRating ScaleSonographic findingsInter-rater reliabilityExpert consensusPleural line abnormalitiesGood inter-rater reliabilityAverage intraclass correlation coefficientSeverity Rating ScalePleural effusionLung aerationSeverity ScaleFourth subsetInterobserver reliabilityCine clipsInfectionUltrasound expertsScanning protocolPathologyB-linesCOVID-19
2022
Mood and Anxiety Disorders and Suicidality in Patients With Newly Diagnosed Focal Epilepsy
Kanner A, Saporta A, Kim D, Barry J, Altalib H, Omotola H, Jette N, O'Brien T, Nadkarni S, Winawer M, Sperling M, French J, Abou-Khalil B, Alldredge B, Bebin M, Cascino G, Cole A, Cook M, Detyniecki K, Devinsky O, Dlugos D, Faught E, Ficker D, Fields M, Gidal B, Gelfand M, Glynn S, Halford J, Haut S, Hegde M, Holmes M, Kalviainen R, Kang J, Klein P, Knowlton R, Krishnamurthy K, Kuzniecky R, Kwan P, Lowenstein D, Marcuse L, Meador K, Mintzer S, Pardoe H, Park K, Penovich P, Singh R, Somerville E, Szabo C, Szaflarski J, Thio K, Trinka E, Burneo J, Project A. Mood and Anxiety Disorders and Suicidality in Patients With Newly Diagnosed Focal Epilepsy. Neurology 2022, 100: e1123-e1134. PMID: 36539302, PMCID: PMC10074468, DOI: 10.1212/wnl.0000000000201671.Peer-Reviewed Original ResearchConceptsMajor depressive disorderFocal epilepsyBipolar disorderSuicidal ideationAnxiety disordersGeneral populationSuicidal attemptsPanic disorderMini International Neuropsychiatric InterviewPrevalence of moodInternational Neuropsychiatric InterviewLogistic regression analysisActive suicidal ideationComparable prevalence ratesSeverity Rating ScaleConsecutive adultsDepressive disorderNeuropsychiatric InterviewEpilepsy evaluationHigh prevalencePrevalence ratesTypes of moodPatientsPsychiatric diagnosisEpilepsyStructural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium
van Velzen LS, Dauvermann MR, Colic L, Villa LM, Savage HS, Toenders YJ, Zhu AH, Bright JK, Campos AI, Salminen LE, Ambrogi S, Ayesa-Arriola R, Banaj N, Başgöze Z, Bauer J, Blair K, Blair RJ, Brosch K, Cheng Y, Colle R, Connolly CG, Corruble E, Couvy-Duchesne B, Crespo-Facorro B, Cullen KR, Dannlowski U, Davey CG, Dohm K, Fullerton JM, Gonul AS, Gotlib IH, Grotegerd D, Hahn T, Harrison BJ, He M, Hickie IB, Ho TC, Iorfino F, Jansen A, Jollant F, Kircher T, Klimes-Dougan B, Klug M, Leehr EJ, Lippard ETC, McLaughlin KA, Meinert S, Miller AB, Mitchell PB, Mwangi B, Nenadić I, Ojha A, Overs BJ, Pfarr JK, Piras F, Ringwald KG, Roberts G, Romer G, Sanches M, Sheridan MA, Soares JC, Spalletta G, Stein F, Teresi GI, Tordesillas-Gutiérrez D, Uyar-Demir A, van der Wee NJA, van der Werff SJ, Vermeiren RRJM, Winter A, Wu MJ, Yang TT, Thompson PM, Rentería ME, Jahanshad N, Blumberg HP, van Harmelen AL, Schmaal L. Structural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium. Molecular Psychiatry 2022, 27: 4550-4560. PMID: 36071108, PMCID: PMC9734039, DOI: 10.1038/s41380-022-01734-0.Peer-Reviewed Original ResearchConceptsMood disordersSuicidal thoughtsSuicide attemptsBrain alterationsMRI metricsSuicidal ideationColumbia-Suicide Severity Rating ScaleStructural brain alterationsLifetime suicide attemptsSeverity Rating ScaleCurrent suicidal ideationActual suicide attemptsHealthy controlsAssessment instrumentsClinical controlEarly interventionMental disordersSignificant associationFrontal poleBrain morphologySuicide riskSuicide attemptersRating ScaleYoung peopleDisorders
2021
Associations Between Justice Involvement and PTSD and Depressive Symptoms, Suicidal Ideation, and Suicide Attempt Among Post-9/11 Veterans
Holliday R, Hoffmire CA, Martin WB, Hoff RA, Monteith LL. Associations Between Justice Involvement and PTSD and Depressive Symptoms, Suicidal Ideation, and Suicide Attempt Among Post-9/11 Veterans. Psychological Trauma Theory Research Practice And Policy 2021, 13: 730-739. PMID: 34323570, PMCID: PMC8563447, DOI: 10.1037/tra0001038.Peer-Reviewed Original ResearchConceptsVHA mental health carePosttraumatic stress disorderMental health careLifetime suicide attemptsRecent suicidal ideationSuicidal ideationSuicide attemptsVHA careJustice-involved veteransDepressive symptomsPatient Health Questionnaire-8Suicide riskJustice involvementVeterans Health Administration (VHA) servicesSevere posttraumatic stress disorderColumbia-Suicide Severity Rating ScaleHealth careMental health servicesSeverity Rating ScalePost-9/11 veteransRecent usePsychiatric symptomsDepression symptomsFemale veteransHealth servicesDemoralization predicts suicidality in patients with cluster headache
Koo BB, Bayoumi A, Albanna A, Abusuliman M, Burrone L, Sico JJ, Schindler EAD. Demoralization predicts suicidality in patients with cluster headache. The Journal Of Headache And Pain 2021, 22: 28. PMID: 33879041, PMCID: PMC8056539, DOI: 10.1186/s10194-021-01241-7.Peer-Reviewed Original ResearchConceptsLifetime suicidal ideationSuicidal ideationHigh suicide riskSuicide riskControl participantsDiagnostic criteriaBrief Lifetime Depression ScaleObservational case-control studyLifetime depression historyColumbia-Suicide Severity Rating ScaleCluster headache patientsCase-control studyEdition diagnostic criteriaActive suicidal ideationStepwise logistic regressionSeverity Rating ScaleCH sufferersLittle empiric dataOrbital painCH diagnosisCluster headacheHeadache patientsHeadache disordersDepression ScaleSuicidal Behaviors Questionnaire
2018
Do unit and post-deployment social support influence the association between deployment sexual trauma and suicidal ideation?
Monteith LL, Hoffmire CA, Holliday R, Park CL, Mazure CM, Hoff RA. Do unit and post-deployment social support influence the association between deployment sexual trauma and suicidal ideation? Psychiatry Research 2018, 270: 673-681. PMID: 30384288, DOI: 10.1016/j.psychres.2018.10.055.Peer-Reviewed Original ResearchConceptsSuicidal ideationSexual traumaUnit supportPost-deployment supportColumbia-Suicide Severity Rating ScaleLifetime suicide attemptsSeverity Rating ScalePosttraumatic stress disorder (PTSD) symptomsSocial supportSexual trauma survivorsElevated riskPossible depressionSuicide attemptsTraumaRating ScaleDisorder symptomsSocial support influenceIdeationIntensive monitoringTrauma survivorsMenAssociationWomenPresent studySurvey of experiencesThe PHQ-9 Item 9 based screening for suicide risk: a validation study of the Patient Health Questionnaire (PHQ)−9 Item 9 with the Columbia Suicide Severity Rating Scale (C-SSRS)
Na PJ, Yaramala SR, Kim JA, Kim H, Goes FS, Zandi PP, Voort J, Sutor B, Croarkin P, Bobo WV. The PHQ-9 Item 9 based screening for suicide risk: a validation study of the Patient Health Questionnaire (PHQ)−9 Item 9 with the Columbia Suicide Severity Rating Scale (C-SSRS). Journal Of Affective Disorders 2018, 232: 34-40. PMID: 29477096, DOI: 10.1016/j.jad.2018.02.045.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCohort StudiesCross-Sectional StudiesDepressionFemaleHumansMaleMiddle AgedNeuropsychological TestsPregnancyReference StandardsRegistriesReproducibility of ResultsRisk AssessmentSensitivity and SpecificitySocioeconomic FactorsSuicidal IdeationSuicideSurveys and QuestionnairesYoung AdultConceptsPatient Health QuestionnaireColumbia-Suicide Severity Rating ScaleSeverity Rating ScaleSuicide riskItem 9Health QuestionnaireRating ScaleGold standardOverall poor resultsSuicide ideationClinical characteristicsOverall cohortCare registriesPHQ-9Depressed patientsClinical subgroupsSuicide itemPatientsPassive thoughtsSurrogate measureRiskPoor resultsFurther investigationIdeationAssessment tool
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