2025
A whole-brain voxel-based analysis of structural abnormalities in PTSD: An ENIGMA-PGC study
See C, Si S, Baird C, Haswell C, Hussain A, Olff M, Veltman D, Frijling J, van Zuiden M, Koch S, Nawijn L, Wang L, Zhu Y, Li G, Neria Y, Zhu X, Suarez-Jimenez B, Zilcha-Mano S, Lazarov A, Stevens J, Ressler K, Fani N, Jovanovic T, van Rooij S, Kaufman M, Lebois L, Rosso I, Olson E, Baker J, Sponheim S, Disner S, Davenport N, Etkin A, Maron-Katz A, Stein M, Shenton M, Stein D, Ipser J, Koopowitz S, Seedat S, du Plessis S, van den Heuvel L, Lissek S, Berg H, Straube T, Hofman D, Baugh L, Forster G, Simons R, Simons J, Magnotta V, Fercho K, Wang X, Cotton A, O'Leary E, Xie H, Grupe D, Nitschke J, Davidson R, Larson C, deRoon-Cassini T, Tomas C, Fitzgerald J, Blackford J, Olatunji B, Gordon E, May G, Nelson S, Lanius R, Théberge J, Densmore M, Neufeld R, Abdallah C, Averill C, Harpaz-Rotem I, Levy I, Krystal J, Geuze E, van Lutterveld R, Dennis E, Tate D, Cifu D, Walker W, Wilde E, van der Wee N, Vermeiren R, van der Werff S, McLaughlin K, Sambrook K, Peverill M, Radua J, Salminen L, Jahanshad N, Thomopoulos S, James A, Valmaggia L, Thompson P, Morey R, Kempton M. A whole-brain voxel-based analysis of structural abnormalities in PTSD: An ENIGMA-PGC study. European Psychiatry 2025, 68: e97. PMID: 40692500, PMCID: PMC12344465, DOI: 10.1192/j.eurpsy.2025.10062.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorder patientsPosttraumatic stress disorderAssociated with GM volumeWhole-brain voxel-based analysisVoxel-based morphometryRegional brain volumesGM volumeBrain volumeDepression severityWhole-brainPosttraumatic stress disorder severityWhole-brain statistical mapsCerebellar WM volumeTrauma-exposed controlsStructural neuroimaging scansSuperior frontal gyrusGray matterStatistical mapsVoxel-wise differencesAnalysis of structural abnormalitiesFrontal gyrusTrauma exposureMemory processesStress disorderWhite matter
2024
Tell Me about yourself: Analyzing self-referential language use in borderline personality disorder
Welch J, Luo W, Ambroise K, Choi Y, Jones K, de Rouen A, Fineberg S. Tell Me about yourself: Analyzing self-referential language use in borderline personality disorder. Journal Of Psychiatric Research 2024, 180: 428-438. PMID: 39536504, PMCID: PMC12061065, DOI: 10.1016/j.jpsychires.2024.11.011.Peer-Reviewed Original ResearchPost-traumatic stress disorderBorderline personality disorderTrauma-exposed controlsMarkers of distressPersonality disorderStress disorderNegative emotionsComorbid borderline personality disorderSelf-ReferenceHealthy controlsNon-psychiatric controlsNegative emotion wordsLexical markersLanguage useTrauma control groupComparing language usePhysical wordLanguage samplesEmotional wordsSelf-referential languageTone wordsIll sampleBetween-group differencesStudy 2Study 1Emotional State Transitions in Trauma-Exposed Individuals With and Without Posttraumatic Stress Disorder
Korem N, Duek O, Spiller T, Ben-Zion Z, Levy I, Harpaz-Rotem I. Emotional State Transitions in Trauma-Exposed Individuals With and Without Posttraumatic Stress Disorder. JAMA Network Open 2024, 7: e246813. PMID: 38625701, PMCID: PMC11022112, DOI: 10.1001/jamanetworkopen.2024.6813.Peer-Reviewed Original ResearchPosttraumatic stress disorderTrauma-exposed individualsEmotional numbing symptomsTrauma-exposed controlsNegative emotional statesNumbing symptomsEmotional numbingDSM-5Valence ratingsStress disorderEmotional statesTrauma-exposed control groupPTSD experiencesPosttraumatic stress disorder symptomsPosttraumatic Stress Disorder ChecklistDSM-5 criteriaAge-related associationsStimulus valencePCL-5Emotional responsesEmotional state transitionEmotional transitionSymptomsParticipantsDisorders
2023
Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods
Yang J, Huggins A, Sun D, Baird C, Haswell C, Frijling J, Olff M, van Zuiden M, Koch S, Nawijn L, Veltman D, Suarez-Jimenez B, Zhu X, Neria Y, Hudson A, Mueller S, Baker J, Lebois L, Kaufman M, Qi R, Lu G, Říha P, Rektor I, Dennis E, Ching C, Thomopoulos S, Salminen L, Jahanshad N, Thompson P, Stein D, Koopowitz S, Ipser J, Seedat S, du Plessis S, van den Heuvel L, Wang L, Zhu Y, Li G, Sierk A, Manthey A, Walter H, Daniels J, Schmahl C, Herzog J, Liberzon I, King A, Angstadt M, Davenport N, Sponheim S, Disner S, Straube T, Hofmann D, Grupe D, Nitschke J, Davidson R, Larson C, deRoon-Cassini T, Blackford J, Olatunji B, Gordon E, May G, Nelson S, Abdallah C, Levy I, Harpaz-Rotem I, Krystal J, Morey R, Sotiras A. Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods. Neuropsychopharmacology 2023, 49: 609-619. PMID: 38017161, PMCID: PMC10789873, DOI: 10.1038/s41386-023-01763-5.Peer-Reviewed Original ResearchPosttraumatic stress disorderStructural covariance networksCortical thicknessPTSD diagnosisInsular cortexPTSD patientsCingulate cortexSymptom severityBilateral superior frontal cortexStress disorderGreater cortical thicknessLower cortical thicknessChildhood trauma severitySuperior frontal cortexRegression analysisAnterior cingulate cortexTrauma-exposed controlsPosterior cingulate cortexPrefrontal regulatory regionsPTSD symptom severityComorbid depressionMotor cortexHealthy controlsFrontal cortexAlcohol abuse
2021
Imaging brain cortisol regulation in PTSD with a target for 11β-hydroxysteroid dehydrogenase type 1
Bhatt S, Hillmer AT, Rusowicz A, Nabulsi N, Matuskey D, Angarita GA, Najafzadeh S, Kapinos M, Southwick SM, Krystal JH, Carson RE, Huang Y, Cosgrove KP. Imaging brain cortisol regulation in PTSD with a target for 11β-hydroxysteroid dehydrogenase type 1. Journal Of Clinical Investigation 2021, 131: e150452. PMID: 34651587, PMCID: PMC8516462, DOI: 10.1172/jci150452.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderPositron emission tomographyVolume of distributionDehydrogenase type 1Trauma-exposed controlsPTSD groupTranslocator proteinType 1Veterans Affairs (VA) National CenterOverall PTSD severityBrain glucocorticoidBrain immuneMethodsSixteen individualsPeripheral cortisolMicroglial markersImmune suppressionTranslational Science AwardsCortisol levelsNIH National CenterTC groupCortisol regulationEmission tomographyStress disorderLower PTSD symptomsPTSD symptoms
2019
Neuroimaging Phenotypes Implicated For GWAS of PTSD Through The PGC And ENIGMA Worldwide Consortia
Morey R, van Rooij S, Dennis E, Hayes J, Stevens J, Haswell C, Jahanshad N, Ipser J, Du Pleiss S, Abdallah C, Miller M, Ressler K, Seedat S, Thompson P, Logue M. Neuroimaging Phenotypes Implicated For GWAS of PTSD Through The PGC And ENIGMA Worldwide Consortia. European Neuropsychopharmacology 2019, 29: s750-s751. DOI: 10.1016/j.euroneuro.2017.06.093.Peer-Reviewed Original ResearchCurrent PTSDSubfield volumesPsychiatric Genomics ConsortiumAmygdala volume differencesRight hippocampal tailHippocampal subfield volumesTrauma-exposed controlsContextual fear memoryAssociation of PTSDRight CA1Lifetime PTSDClinical dataHippocampal tailHippocampal subfieldsHippocampusConsortium studySubcortical structuresNeuroimaging studiesLargest neuroimaging studyAmygdalaENIGMA consortiumFear memoryChildhood traumaPTSD symptomatologyBrain responses
2016
S04-3 Assessing the dissociative ptsd subtype in a representative sample of us military veterans
Armour C, Tsai J, Pietrzak R. S04-3 Assessing the dissociative ptsd subtype in a representative sample of us military veterans. Occupational And Environmental Medicine 2016, 73: a100. DOI: 10.1136/oemed-2016-103951.269.Peer-Reviewed Original ResearchPosttraumatic stress disorderDissociative subtypeU.S. veteransDSM-5 posttraumatic stress disorderQuality of lifeAnonymous web-based surveyInitial screening questionsUS military veteransTrauma-exposed controlsDSM-5 versionSevere PTSD symptomsDissociative PTSD subtypeClinical characteristicsAlcohol use problemsCurrent study sampleNational HealthRepresentative sampleScreening questionsResponse rateWeb-based surveyMental disordersVeterans StudyPTSD subtypesU.S. adultsPTSD ChecklistGenome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers
Stein MB, Chen CY, Ursano RJ, Cai T, Gelernter J, Heeringa SG, Jain S, Jensen KP, Maihofer AX, Mitchell C, Nievergelt CM, Nock MK, Neale BM, Polimanti R, Ripke S, Sun X, Thomas ML, Wang Q, Ware EB, Borja S, Kessler RC, Smoller JW. Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers. JAMA Psychiatry 2016, 73: 695-704. PMID: 27167565, PMCID: PMC4936936, DOI: 10.1001/jamapsychiatry.2016.0350.Peer-Reviewed Original ResearchMeSH KeywordsAdultCarrier ProteinsCase-Control StudiesChromosomes, Human, Pair 19Chromosomes, Human, Pair 5Cohort StudiesFemaleGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMilitary PersonnelPolymorphism, Single NucleotideStress Disorders, Post-TraumaticYoung AdultConceptsPosttraumatic stress disorderTrauma-exposed controlsNew Soldier StudyRheumatoid arthritisStress disorderLifetime posttraumatic stress disorderSerious public health concernUnique participantsImmune-related disordersCumulative trauma exposureGenetic risk factorsPublic health concernLogistic regression modelsUS Army soldiersGenome-wide association studiesInflammatory disordersLifetime riskRisk factorsMAIN OUTCOMEPrimary analysisPost Deployment StudyAssociation studiesControl individualsMental disordersSignificant association
2015
Dissociative subtype of DSM-5 posttraumatic stress disorder in U.S. veterans
Tsai J, Armour C, Southwick SM, Pietrzak RH. Dissociative subtype of DSM-5 posttraumatic stress disorder in U.S. veterans. Journal Of Psychiatric Research 2015, 66: 67-74. PMID: 25969340, DOI: 10.1016/j.jpsychires.2015.04.017.Peer-Reviewed Original ResearchConceptsDSM-5 posttraumatic stress disorderPosttraumatic stress disorderDissociative subtypeAlcohol use problemsU.S. veteransStress disorderDissociative symptomsUse problemsQuality of lifeTrauma-exposed controlsSevere PTSD symptomsClinical characteristicsMultivariable analysisPTSD symptom severityNational HealthVeterans StudyMental disordersSymptom severitySubtypesSymptomsMore depressionImportance of assessingPTSD symptomsStatistical ManualAnxiety symptoms
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