2025
No Time for That: Health Care Economics and Population Health Limitations of Anal Cancer Screening
Esposito A, Rojas A, Leeds I. No Time for That: Health Care Economics and Population Health Limitations of Anal Cancer Screening. Clinics In Colon And Rectal Surgery 2025 DOI: 10.1055/s-0045-1809892.Peer-Reviewed Original ResearchAnal cancer screeningCancer screeningRates of anal cancerHealth care economicsPopulation screening toolHigh-risk populationHigh-Resolution AnoscopyHealth limitationsNational guidelinesCare economicsTraining providersScreening toolProvidersAnal cancerHigh-grade squamous intraepithelial lesionsSquamous intraepithelial lesionsPopulationScreeningIntraepithelial lesionsHealthIntegral componentAnoscopyGuidelinesNo timeMonetary costHuman papillomavirus genotype distribution and its correlation with intraepithelial neoplasia, vaccination, and ethnicity
Abi-Raad R, Sun T, Krishnamurti U. Human papillomavirus genotype distribution and its correlation with intraepithelial neoplasia, vaccination, and ethnicity. Journal Of The American Society Of Cytopathology 2025, 14: 273-278. PMID: 40307088, DOI: 10.1016/j.jasc.2025.03.006.Peer-Reviewed Original ResearchConceptsHigh-risk human papillomavirusNon-16/18ASC-HHPV genotypesIntraepithelial neoplasiaCases of high-grade squamous intraepithelial lesionCervical cancerPositive high-risk HPVHigh-risk HPVHigh-risk human papillomavirus genotypesHuman papillomavirus genotype distributionNon-16/18 HPV genotypesPrevalence of HPV genotypesHigh-risk human papillomavirus typesHigh-grade intraepithelial neoplasiaIntroduction of HPV vaccinationIncidence of cervical cancerAtypical squamous cellsSquamous intraepithelial lesionsHigh-grade lesionsHSIL patientsNonvaccinated womenIntraepithelial lesionsVaccinated womenSquamous cells
2023
TP53 Mutation-driven Stratified Mucin-producing Carcinoma Coexisting With Squamous Cell Carcinoma of the Vulva: A Case Study
Wadia R, McHenry A, Abi-Raad R, Hui P. TP53 Mutation-driven Stratified Mucin-producing Carcinoma Coexisting With Squamous Cell Carcinoma of the Vulva: A Case Study. International Journal Of Gynecological Pathology 2023, 42: 555-560. PMID: 37255422, DOI: 10.1097/pgp.0000000000000961.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaInvasive squamous cell carcinomaVulvar intraepithelial neoplasiaCell carcinomaIntraepithelial neoplasiaLichen sclerosusAssociated with high-risk human papillomavirus infectionHigh-risk human papillomavirus infectionDifferentiated vulvar intraepithelial neoplasiaPresence of lymphovascular invasionInguinal lymph node metastasisHuman papillomavirus infectionVulvar lichen sclerosusMucin-producing carcinomaLymph node metastasisIntraepithelial lesionsLymphovascular invasionTP53 mutationsNode metastasisPapillomavirus infectionNeoplastic componentsCarcinomaUnique caseTP53Sclerosus
2022
Human papillomavirus 16/18/45 are not the most frequent genotypes in African American women: analysis in cervical Papanicolaou smears of women in an inner-city hospital
Dababneh M, Birdsong G, Mosunjac M, Krishnamurti U. Human papillomavirus 16/18/45 are not the most frequent genotypes in African American women: analysis in cervical Papanicolaou smears of women in an inner-city hospital. Journal Of The American Society Of Cytopathology 2022, 12: 120-125. PMID: 36585313, DOI: 10.1016/j.jasc.2022.11.005.Peer-Reviewed Original ResearchConceptsHR-HPV genotypesAfrican American womenIntraepithelial lesionsPap testHigh-grade squamous intraepithelial lesion casesHigh-grade squamous intraepithelial lesionsCommon high-risk HPVHPV molecular testingHigh-risk HPVSquamous intraepithelial lesionsCervical Pap testBethesda classification systemCommon human papillomavirusCervical Papanicolaou smearsInner-city hospitalSecondary prevention methodsAmerican womenHR-HPVHPV vaccineHPV genotypesCervical cancerHuman papillomavirusPapanicolaou smearsAfrican American populationLesion cases
2021
Unindicated cervical cancer screening in adolescent females within a large healthcare system in the United States
Hosier H, Sheth SS, Oliveira CR, Perley LE, Vash-Margita A. Unindicated cervical cancer screening in adolescent females within a large healthcare system in the United States. American Journal Of Obstetrics And Gynecology 2021, 225: 649.e1-649.e9. PMID: 34256029, PMCID: PMC8633062, DOI: 10.1016/j.ajog.2021.07.005.Peer-Reviewed Original ResearchConceptsCervical cancerLarge healthcare systemYears of ageIncidence rateScreening testAdolescent femalesHealthcare systemLarge multihospital health systemCervical cancer screening resultsNew cervical cancer casesCurrent consensus recommendationsHuman papillomavirus testingHuman papillomavirus vaccinationCervical cancer casesCervical cancer screeningMultihospital health systemCancer risk reductionScreening resultsPoisson regression analysisEvidence-based strategiesGuideline nonadherencePapillomavirus vaccinationCytology testingIntraepithelial lesionsProvider factorsIncreases in Human Papillomavirus Testing Preceding Diagnosis of Cervical Precancer in 5 US States, 2008–2016
Cleveland AA, Gargano JW, Griffin MR, Park IU, Niccolai LM, Bennett NM, Pemmaraju M, Fink D, Brackney M, Scahill M, Ehlers SJ, Unger ER, Markowitz LE, Group T. Increases in Human Papillomavirus Testing Preceding Diagnosis of Cervical Precancer in 5 US States, 2008–2016. Journal Of Lower Genital Tract Disease 2021, 25: 192-198. PMID: 33797511, DOI: 10.1097/lgt.0000000000000606.Peer-Reviewed Original ResearchConceptsHPV testProportion of womenCervical precancerCytology resultsAge groupsHuman papillomavirus testingAtypical squamous cellsAtypical glandular cellsCervical intraepithelial neoplasiaWomen 30 yearsCross-sectional analysisHPV testingCervical diseaseIntraepithelial lesionsIntraepithelial neoplasiaSquamous cellsLaboratory surveillanceMost womenUnknown significanceGlandular cellsDiagnosisPrecancerWomenCIN2YearsDiseases of the Fallopian Tube
Xing D, Snir O, Hui P. Diseases of the Fallopian Tube. Practical Anatomic Pathology 2021, 193-223. DOI: 10.1007/978-3-030-68608-6_8.Peer-Reviewed Original ResearchSerous tubal intraepithelial carcinomaSerous tubal intraepithelial lesionsSecretory cell outgrowthsFallopian tubeSerous carcinomaPrimary fallopian tube carcinomaHigh-grade serous carcinomaFallopian tube neoplasmsLikelihood of overdiagnosisFallopian tube carcinomaTubal intraepithelial carcinomaTubal intraepithelial lesionsNon-neoplastic lesionsSpectrum of entitiesProbable Wolffian originFemale adnexal tumorNongynecologic originEctopic pregnancyMiscellaneous tumorsIntraepithelial lesionsP53 signatureRelated complicationsChronic inflammationIntraepithelial carcinomaMetastatic carcinoma
2020
PD-L1 Expression in Anal Intraepithelial Neoplasia Versus. Invasive Squamous Cell Carcinoma
Monsrud A, Avadhani V, Mosunjac M, Krishnamurti U. PD-L1 Expression in Anal Intraepithelial Neoplasia Versus. Invasive Squamous Cell Carcinoma. American Journal Of Clinical Pathology 2020, 154: s67-s67. DOI: 10.1093/ajcp/aqaa161.146.Peer-Reviewed Original ResearchInvasive squamous cell carcinomaPD-L1 positivityPD-L1 expressionCases of ISCCSquamous cell carcinomaTumor proportion scoreSquamous intraepithelial lesionsPD-L1Normal mucosaIntraepithelial lesionsCell carcinomaGranular cytoplasmic stainingInvasive carcinomaProportion scoreLow-grade squamous intraepithelial lesionsCytoplasmic stainingPD-L1 positive casesAnal squamous intraepithelial lesionsHigh-grade intraepithelial lesionsGrade squamous intraepithelial lesionNuclear stainingAnal intraepithelial neoplasiaPD-L1 inhibitorsAberrant nuclear stainingAIN 2
2018
Fallopian tube lesions in women at high risk for ovarian cancer: A multicenter study
Visvanathan K, Shaw P, May BJ, Bahadirli-Talbot A, Kaushiva A, Risch H, Narod S, Wang TL, Parkash V, Vang R, Levine DA, Soslow R, Kurman R, Shih IM. Fallopian tube lesions in women at high risk for ovarian cancer: A multicenter study. Cancer Prevention Research 2018, 11: canprevres.0009.2018. PMID: 30232083, PMCID: PMC6760670, DOI: 10.1158/1940-6207.capr-18-0009.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsBiomarkers, TumorBRCA1 ProteinBRCA2 ProteinCystadenocarcinoma, SerousDisease ProgressionFallopian Tube NeoplasmsFallopian TubesFemaleHumansMedical History TakingMiddle AgedOvarian NeoplasmsOvaryPrecancerous ConditionsPrevalencePrognosisProspective StudiesRetrospective StudiesSalpingo-oophorectomyConceptsSerous tubal intraepithelial lesionsHigh-grade serous ovarian carcinomaSerous tubal intraepithelial carcinomaP53 signatureRisk/protective factorsProtective factorsMultiple lesionsFallopian tubePrognosis of womenHigh-risk womenTubal intraepithelial carcinomaTubal intraepithelial lesionsSerous ovarian carcinomaPutative precursor lesionsYears of ageIntraepithelial lesionsIntraepithelial carcinomaMulticenter studyInvasive cancerOvarian carcinomaDisease progressionPrecursor lesionsEpidemiologic dataCombined prevalenceTubal lesionsBiomarker P16 predicts progression risk of anal low-grade squamous intraepithelial lesions
Liu Y, Blakely M, Sigel K, Thin TH, Hui P, Donovan M, Gaisa MM. Biomarker P16 predicts progression risk of anal low-grade squamous intraepithelial lesions. AIDS 2018, 32: 2309-2316. PMID: 30005024, PMCID: PMC6862769, DOI: 10.1097/qad.0000000000001957.Peer-Reviewed Original ResearchConceptsLow-grade squamous intraepithelial lesionsAnal low-grade squamous intraepithelial lesionsSquamous intraepithelial lesionsHigh-grade squamous intraepithelial lesionsBiomarker p16Intraepithelial lesionsIndex lesionP16 immunohistochemistryProgression riskHigh-risk human papillomavirus DNACD4 T-cell countFormer smoker statusHistory of condylomaT-cell countsHR-HPV DNAYear of diagnosisHuman papillomavirus DNASemi-quantitative scoring systemAssociation of predictorsLogistic regression modelsOnly significant predictorOrdinal logistic regression modelsClinical outcomesUnderwent surveillanceRetrospective study
2015
Cytology as a screening tool for anal squamous intraepithelial lesion for HIV positive men: 10-year experience in an inner city hospital
Johnson G, Nguyen M, Krishnamurti U, Seydafkan S, Flowers L, Ehdaivand S, Mosunjac M. Cytology as a screening tool for anal squamous intraepithelial lesion for HIV positive men: 10-year experience in an inner city hospital. Journal Of The American Society Of Cytopathology 2015, 5: 145-153. PMID: 31042517, DOI: 10.1016/j.jasc.2015.08.003.Peer-Reviewed Original ResearchLow-grade squamous intraepithelial lesionsSquamous intraepithelial lesionsHigh-risk patientsAnal cytologyIntraepithelial lesionsInner-city hospitalHuman papillomavirusAnal intraepithelial neoplasia grade 2High-grade squamous intraepithelial lesionsAnal squamous intraepithelial lesionsAnal cytology specimensPercent of patientsAtypical squamous cellsHIV-positive menHuman immunodeficiency virusHigh-risk populationASC-US casesMethod of biopsyDegree of dysplasiaPositive predictive valueCytology-histology correlationRate of detectionClear guidelinesHPV testingAnal carcinomaGrading of atypia in genital skin lesions: routine microscopic evaluation and use of p16 immunostaining
Ezaldein H, Lott JP, McNiff JM, Hui P, Buza N, Ko CJ. Grading of atypia in genital skin lesions: routine microscopic evaluation and use of p16 immunostaining. Journal Of Cutaneous Pathology 2015, 42: 519-526. PMID: 25951050, DOI: 10.1111/cup.12525.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkers, TumorCross-Sectional StudiesCyclin-Dependent Kinase Inhibitor p16FemaleGenitalia, FemaleHumansImmunohistochemistryMaleMiddle AgedNeoplasm ProteinsObserver VariationPapillomavirus InfectionsSensitivity and SpecificitySkin DiseasesSquamous Intraepithelial Lesions of the CervixUterine Cervical NeoplasmsConceptsGenital skin lesionsHigh-grade squamous intraepithelial lesionsLow-grade squamous intraepithelial lesionsSquamous intraepithelial lesionsP16 immunostainingSkin lesionsDiagnostic agreementIntraepithelial lesionsUseful adjunctive markerHigh-grade dysplasiaCross-sectional studyRoutine microscopic evaluationDegree of atypiaAdjunctive markerInter-observer agreementPrimary outcomeCervical lesionsHistopathologic assessmentHistopathologic evaluationConsensus diagnosisReactive atypiaEosin stainingOriginal diagnosisAtypiaLesionsPrevalence and risk factors of cervical squamous intraepithelial lesions among HIV-infected women in Dar es Salaam, Tanzania
Liu E, McCree R, Mtisi E, Fawzi WW, Aris E, Lema IA, Hertzmark E, Chalamilla G, Li N, Vermund SH, Spiegelman D. Prevalence and risk factors of cervical squamous intraepithelial lesions among HIV-infected women in Dar es Salaam, Tanzania. International Journal Of STD & AIDS 2015, 27: 219-225. PMID: 25957324, PMCID: PMC11340030, DOI: 10.1177/0956462415584466.Peer-Reviewed Original ResearchConceptsCervical squamous intraepithelial lesionsSquamous intraepithelial lesionsHIV disease stageCell countIntraepithelial lesionsDisease stageHigh-grade squamous intraepithelial lesionsAdvanced HIV disease stageCervical cancer prevention servicesLow CD4 cell countsCD4 cell countCancer prevention servicesCross-sectional studyResource-limited settingsCervical inflammationLow CD4Median CD4HIV careMedian ageCervical screeningPapanicolaou smearsRisk factorsTreatment clinicsPrevention servicesHIVPrevalence of Human Papillomavirus Genotypes among African Women with Normal Cervical Cytology and Neoplasia: A Systematic Review and Meta-Analysis
Ogembo RK, Gona PN, Seymour AJ, Park HS, Bain PA, Maranda L, Ogembo JG. Prevalence of Human Papillomavirus Genotypes among African Women with Normal Cervical Cytology and Neoplasia: A Systematic Review and Meta-Analysis. PLOS ONE 2015, 10: e0122488. PMID: 25875167, PMCID: PMC4396854, DOI: 10.1371/journal.pone.0122488.Peer-Reviewed Original ResearchConceptsHigh-grade squamous intraepithelial lesionsLow-grade squamous intraepithelial lesionsInvasive cervical carcinomaNormal cervical cytologySquamous intraepithelial lesionsHuman papillomavirusIntraepithelial lesionsCervical cytologyOverall prevalenceMeta-analysisSystematic reviewHPV type-specific prevalenceAfrican womenCervical neoplastic diseaseHPV genotype prevalencePrevalent human papillomavirusesType-specific prevalenceAtypical squamous cellsCervical cancer morbidityCervical cancer casesHuman papillomavirus genotypesHigh-risk genotypesInternational Prospective RegisterMeta-Analyses (PRISMA) guidelinesPreferred Reporting Items
2014
Clinical Performance of Digital Cervicography and Cytology for Cervical Cancer Screening in HIV-Infected Women in Lusaka, Zambia
Bateman AC, Parham GP, Sahasrabuddhe VV, Mwanahamuntu MH, Kapambwe S, Katundu K, Nkole T, Mulundika J, Pfaendler KS, Hicks ML, Shibemba A, Vermund SH, Stringer JS, Chibwesha CJ. Clinical Performance of Digital Cervicography and Cytology for Cervical Cancer Screening in HIV-Infected Women in Lusaka, Zambia. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2014, 67: 212-215. PMID: 24977474, PMCID: PMC4162769, DOI: 10.1097/qai.0000000000000270.Peer-Reviewed Original ResearchConceptsClinical performanceDigital cervicographyCervical intraepithelial neoplasia grade 2High-grade squamous intraepithelial lesionsCervical cancer screeningSquamous intraepithelial lesionsIntraepithelial lesionsCancer screeningCervicographyGrade 2HIVCytologyWomenLesionsVisual inspectionSpecificity
2012
Implementation of cervical cancer screening using visual inspection with acetic acid in rural Mozambique: successes and challenges using HIV care and treatment programme investments in Zambézia Province
Moon TD, Silva‐Matos C, Cordoso A, Baptista AJ, Sidat M, Vermund SH. Implementation of cervical cancer screening using visual inspection with acetic acid in rural Mozambique: successes and challenges using HIV care and treatment programme investments in Zambézia Province. Journal Of The International AIDS Society 2012, 15: 17406. PMID: 22713260, PMCID: PMC3499800, DOI: 10.7448/ias.15.2.17406.Peer-Reviewed Original ResearchConceptsLoop electrosurgical excision procedureHIV careCervical cancerProvincial HospitalZambézia ProvinceCervical cancer screening servicesMaternal child health nursesAntiretroviral therapy rolloutVIA-positive womenCancer screening servicesElectrosurgical excision procedureChild health nursesSquamous intraepithelial lesionsCervical cancer screeningChronic disease screeningHealth manpower shortagesRural MozambiqueExcision procedureHIV testingIntraepithelial lesionsHIV statusClinic nursesScreening servicesCancer screeningHealth nurses
2011
Use of high‐risk human papillomavirus testing in patients with low‐grade squamous intraepithelial lesions
Levi AW, Harigopal M, Hui P, Schofield K, Chhieng DC. Use of high‐risk human papillomavirus testing in patients with low‐grade squamous intraepithelial lesions. Cancer Cytopathology 2011, 119: 228-234. PMID: 21732551, DOI: 10.1002/cncy.20172.Peer-Reviewed Original ResearchConceptsLow-grade squamous intraepithelial lesionsHR-HPV testingHPV testingCIN 2Colposcopy rateHR-HPVRelative light units/cutoffCervical intraepithelial neoplasia 2High-risk human papillomavirusHR-HPV statusRLU/COIntraepithelial neoplasia 2Hybrid Capture 2Squamous intraepithelial lesionsCIN 1 lesionsLarge teaching hospitalNegative predictive valueLSIL cytologyHPV statusIntraepithelial lesionsCapture 2Human papillomavirusTeaching hospitalCytologic diagnosisSevere lesionsComparison of visual inspection with acetic acid and cervical cytology to detect high‐grade cervical neoplasia among HIV‐infected women in India
Sahasrabuddhe VV, Bhosale RA, Kavatkar AN, Nagwanshi CA, Joshi SN, Jenkins CA, Shepherd BE, Kelkar RS, Sahay S, Risbud AR, Vermund SH, Mehendale SM. Comparison of visual inspection with acetic acid and cervical cytology to detect high‐grade cervical neoplasia among HIV‐infected women in India. International Journal Of Cancer 2011, 130: 234-240. PMID: 21387289, PMCID: PMC3516675, DOI: 10.1002/ijc.25971.Peer-Reviewed Original ResearchMeSH KeywordsAcetatesAdultCervix UteriColposcopyCross-Sectional StudiesCytodiagnosisDNA, ViralFemaleHIVHIV InfectionsHumansIndiaMass ScreeningPapanicolaou TestPolymerase Chain ReactionPredictive Value of TestsSensitivity and SpecificityUterine Cervical DysplasiaUterine Cervical NeoplasmsVaginal SmearsConceptsCervical cytologyHigh-grade squamous intraepithelial lesionsHigh-grade cervical neoplasiaNegative predictive value estimatesScreening testHPV-positive CIN2Atypical squamous cellsSquamous intraepithelial lesionsHuman immunodeficiency virusConventional cervical cytologyPredictive value estimatesSecondary prevention methodsNonpregnant HIVRigorous endpointsAntiretroviral therapyHIV/Intraepithelial lesionsCervical neoplasiaCervical cancerImmunodeficiency virusSquamous cellsHuman papillomavirusUndetermined significanceIntraepithelial cellsCare program
2009
Anal squamous intraepithelial lesions among HIV positive and HIV negative men who have sex with men in Thailand
Li AH, Phanuphak N, Sahasrabuddhe VV, Chaithongwongwatthana S, Vermund SH, Jenkins CA, Shepherd BE, Teeratakulpisarn N, van der Lugt J, Avihingsanon A, Ruxrungtham K, Shikuma C, Phanuphak P, Ananworanich J. Anal squamous intraepithelial lesions among HIV positive and HIV negative men who have sex with men in Thailand. Sexually Transmitted Infections 2009, 85: 503. PMID: 19525263, PMCID: PMC3875384, DOI: 10.1136/sti.2009.036707.Peer-Reviewed Original ResearchConceptsAnal squamous intraepithelial lesionsHigh-grade squamous intraepithelial lesionsLow-grade squamous intraepithelial lesionsHIV-negative MSMSquamous intraepithelial lesionsHIV-positive MSMNegative MSMHIV-negative menIntraepithelial lesionsPositive MSMRisk factorsAnal condylomaNegative menActive antiretroviral therapy (HAART) useAbnormal anal cytologyAnal cancer precursorsAnal Pap smearsAnal precancerous lesionsAntiretroviral therapy useT-cell countsAtypical squamous cellsSignificant risk factorsAnal cytologyAsian HIVTherapy use
2008
High grade cervical intraepithelial neoplasia and viral load of high-risk human papillomavirus: significant correlations in patients of 22 years old or younger.
Xu Y, Dotto J, Hui Y, Lawton K, Schofield K, Hui P. High grade cervical intraepithelial neoplasia and viral load of high-risk human papillomavirus: significant correlations in patients of 22 years old or younger. International Journal Of Clinical And Experimental Pathology 2008, 2: 169-75. PMID: 19079652, PMCID: PMC2583634.Peer-Reviewed Original ResearchHigh viral loadHigh-grade squamous intraepithelial lesionsHigh-risk human papillomavirusSquamous intraepithelial lesionsViral loadHR-HPVHPV loadIntraepithelial lesionsHistological gradeHuman papillomavirusHigh-grade cervical intraepithelial neoplasiaHigh-grade cervical dysplasiaGrade squamous intraepithelial lesionHigh HPV loadHR-HPV testingAssociation of HPVCervical intraepithelial neoplasiaHigh-grade dysplasiaLow-grade dysplasiaViral load dataLogistic regression analysisAge-dependent mannerPatient ageCervical dysplasiaCervical biopsies
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply