2024
Discovering Novel and Unique Saliva and Serum miRNA and mRNA Signatures for Oral Cancer Detection Using Whole Transcriptome and Small Non-Coding RNA Sequencing: Prediction of Their Association With the PI3K/AKT Pathway
Vageli D, Doukas P, Judson B. Discovering Novel and Unique Saliva and Serum miRNA and mRNA Signatures for Oral Cancer Detection Using Whole Transcriptome and Small Non-Coding RNA Sequencing: Prediction of Their Association With the PI3K/AKT Pathway. JCO Global Oncology 2024, 10: 52-52. DOI: 10.1200/go-24-47000.Peer-Reviewed Original ResearchSerum miRNAsPanel of miRNAsHsa-miR-7704Oral squamous cell carcinomaSmall non-coding RNA sequencesHealthy controlsSerum of OSCC patientsMiRNAsMRNA markersOral cavity cancer patientsMRNA signatureDetection of oral cancerOral cavity cancerIdentification of molecular biomarkersSquamous cell carcinomaNon-invasive biomarkersSerum samplesUnique miRNAsOral cancer detectionPost-treatment monitoringCell carcinomaOral cancerNon-coding RNA sequencesOSCC patientsCancer patientsEfficacy of 5% methylene blue photodynamic therapy in the treatment of potentially malignant oral disorders: a randomized, double-blind, controlled trial
de Freitas Silva B, Rocha R, Prudente T, de Oliveira Lenza M, Ferraz D, Mezaiko E, do Couto Lima Moreira F, Yamamoto-Silva F. Efficacy of 5% methylene blue photodynamic therapy in the treatment of potentially malignant oral disorders: a randomized, double-blind, controlled trial. International Journal Of Clinical Trials 2024, 11: 207-214. DOI: 10.18203/2349-3259.ijct20242003.Peer-Reviewed Original ResearchMalignant oral disordersOral leukoplakiaPhotodynamic therapyOral disordersSecondary prevention of oral cancerMethylene blue photodynamic therapyDouble-blind clinical trialPrevention of oral cancerEfficacy of photodynamic therapyMalignant transformation rateAminolevulinic acidTreatment of OLClinical remissionDouble-blindCost of treatmentOral cancerClinical trialsPrimary outcomeSecondary outcomesSecondary preventionTreatment protocolsExtensive lesionsRisk factorsConventional treatmentControlled TrialsImmune infiltration at the primary tumor is associated with clinical outcome of patients with extranodal extension of lymph node metastasis in oral cancer
Michikawa C, Gleber-Netto F, Pickering C, Rao X, Wang J, Sikora A, Myers J, Frederick M. Immune infiltration at the primary tumor is associated with clinical outcome of patients with extranodal extension of lymph node metastasis in oral cancer. Oral Oncology 2024, 153: 106729. PMID: 38663156, DOI: 10.1016/j.oraloncology.2024.106729.Peer-Reviewed Original ResearchConceptsOral cavity squamous cell carcinomaAssociated with clinical outcomesExtranodal extensionLymph node metastasisImmune infiltrationImmune infiltration statusOverall survivalPrimary tumorNode metastasisOral cancerInfiltration statusClinical outcomes of OSCC patientsExtension of lymph node metastasesAssociated with clinical outcomes of patientsAssociated with OS rateLocally advanced oral cancerClinical outcomes of patientsOutcome of OSCC patientsAssociated with poor overall survivalImmune infiltration of tumorsLow immune infiltrationNode negative tumorsAdvanced oral cancerHuman papillomavirus-negativeInfiltration of tumors
2023
A Novel Saliva and Serum miRNA Panel as a Potential Useful Index for Oral Cancer and the Association of miR-21 with Smoking History: a Pilot Study.
Vageli D, Doukas P, Shah R, Boyi T, Liu C, Judson B. A Novel Saliva and Serum miRNA Panel as a Potential Useful Index for Oral Cancer and the Association of miR-21 with Smoking History: a Pilot Study. Cancer Prevention Research 2023, 16: 653-659. PMID: 37683274, DOI: 10.1158/1940-6207.capr-23-0219.Peer-Reviewed Original ResearchConceptsOral squamous cell carcinomaSerum miR-21Oral cancerMiR-136MiR-21Smoking historyPilot studySerum miRNAsEarly-stage oral squamous cell carcinomaMiR-29bSquamous cell carcinomaEarly malignant lesionsEarly-stage tumorsSerum miRNA panelFurther validationUseful indexSmoking statusCell carcinomaHealthy controlsPoor survivalTobacco useHealthy volunteersLarge cohortMalignant lesionsSmokersRecent and advanced therapy for oral cancer
Baskar G, Palaniyandi T, Viswanathan S, Wahab M, Surendran H, Ravi M, Sivaji A, Rajendran B, Natarajan S, Govindasamy G. Recent and advanced therapy for oral cancer. Biotechnology And Bioengineering 2023, 120: 3105-3115. PMID: 37243814, DOI: 10.1002/bit.28452.Peer-Reviewed Original Research
2022
Genetic Changes Driving Immunosuppressive Microenvironments in Oral Premalignancy
Rangel R, Pickering CR, Sikora AG, Spiotto MT. Genetic Changes Driving Immunosuppressive Microenvironments in Oral Premalignancy. Frontiers In Immunology 2022, 13: 840923. PMID: 35154165, PMCID: PMC8829003, DOI: 10.3389/fimmu.2022.840923.Peer-Reviewed Original ResearchConceptsOral premalignant lesionsImmunosuppressive microenvironmentProgression of OPLsOral cavity cancerGenomic alterationsImmune microenvironmentOral cancerOSCC progressionInflammatory environmentPremalignant lesionsSpecific genomic changesOral premalignancyTherapeutic approachesNovel biomarkersMalignant transformationMicroenvironmental changesCancerProgressionGenomic changesMicroenvironmentAlterationsGenetic changesPremalignancyTherapyLesions
2020
Tea Consumption and Risk of Cancer: An Umbrella Review and Meta-Analysis of Observational Studies
Kim T, Jeong G, Yang J, Lee K, Kronbichler A, van der Vliet H, Grosso G, Galvano F, Aune D, Kim J, Veronese N, Stubbs B, Solmi M, Koyanagi A, Hong S, Dragioti E, Cho E, de Rezende L, Giovannucci E, Shin J, Gamerith G. Tea Consumption and Risk of Cancer: An Umbrella Review and Meta-Analysis of Observational Studies. Advances In Nutrition 2020, 11: 1437-1452. PMID: 32667980, PMCID: PMC7666907, DOI: 10.1093/advances/nmaa077.Peer-Reviewed Original ResearchConceptsTea consumptionUmbrella reviewCancer riskReduced risk of oral cancerMeta-analyses of observational studiesObservational studyAssociated with cancer riskMeta-analysis of observational studiesMeta-analysesSmall-study effectsRisk of oral cancerBetween-study heterogeneityOral cancerLevel of evidenceWell-designed prospective studiesSuggestive evidenceEffect sizeReduced riskMeta-analysisGynecologic cancerOrgan cancersBreast cancerConsumed beveragesProspective studyAssociationLoss of p53 drives neuron reprogramming in head and neck cancer
Amit M, Takahashi H, Dragomir MP, Lindemann A, Gleber-Netto FO, Pickering CR, Anfossi S, Osman AA, Cai Y, Wang R, Knutsen E, Shimizu M, Ivan C, Rao X, Wang J, Silverman DA, Tam S, Zhao M, Caulin C, Zinger A, Tasciotti E, Dougherty PM, El-Naggar A, Calin GA, Myers JN. Loss of p53 drives neuron reprogramming in head and neck cancer. Nature 2020, 578: 449-454. PMID: 32051587, PMCID: PMC9723538, DOI: 10.1038/s41586-020-1996-3.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic AntagonistsAdrenergic NeuronsAnimalsCell DivisionCell TransdifferentiationCellular ReprogrammingDisease Models, AnimalDisease ProgressionFemaleHumansMaleMiceMice, Inbred BALB CMicroRNAsMouth NeoplasmsNerve FibersNeuritesReceptors, AdrenergicRetrospective StudiesSensory Receptor CellsTumor MicroenvironmentTumor Suppressor Protein p53Xenograft Model Antitumor AssaysConceptsOral cancerNerve fibersAdrenergic nerve fibersPoor clinical outcomeTrigeminal sensory neuronsLoss of TP53Sensory denervationAdrenergic nervesChemical sympathectomyNerve densitySensory nervesClinical outcomesSolid tumor microenvironmentLoss of p53Neck cancerPharmacological blockadeEndogenous neuronsRetrospective analysisMouse modelSensory neuronsAdrenergic phenotypeAdrenergic receptorsTumor growthTumor progressionTumor microenvironment
2018
Changing prognosis of oral cancer: An analysis of survival and treatment between 1973 and 2014
Cheraghlou S, Schettino A, Zogg CK, Judson BL. Changing prognosis of oral cancer: An analysis of survival and treatment between 1973 and 2014. The Laryngoscope 2018, 128: 2762-2769. PMID: 30194691, DOI: 10.1002/lary.27315.Peer-Reviewed Original ResearchConceptsOral cavity cancerLate-stage diseaseAdjuvant therapyOral cancerEnd Results 9 registriesCox survival regressionHigher nodal yieldsNational Cancer DatabaseEarly-stage diseaseKaplan-Meier analysisRetrospective database analysisAnalysis of survivalAdjuvant chemoradiotherapyNodal yieldAdult patientsNeck dissectionRetrospective studyCancer DatabasePrognosisPatientsCancerDiseaseDatabase analysisSurvival regressionChemoradiotherapy
2017
Replication Stress Leading to Apoptosis within the S-phase Contributes to Synergism between Vorinostat and AZD1775 in HNSCC Harboring High-Risk TP53 Mutation
Tanaka N, Patel AA, Tang L, Silver NL, Lindemann A, Takahashi H, Jaksik R, Rao X, Kalu NN, Chen TC, Wang J, Frederick MJ, Johnson F, Gleber-Netto FO, Fu S, Kimmel M, Wang J, Hittelman WN, Pickering CR, Myers JN, Osman AA. Replication Stress Leading to Apoptosis within the S-phase Contributes to Synergism between Vorinostat and AZD1775 in HNSCC Harboring High-Risk TP53 Mutation. Clinical Cancer Research 2017, 23: 6541-6554. PMID: 28790110, PMCID: PMC5724758, DOI: 10.1158/1078-0432.ccr-17-0947.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCarcinoma, Squamous CellCell Cycle ProteinsCell Line, TumorCell ProliferationDNA DamageDNA ReplicationDrug SynergismFemaleHead and Neck NeoplasmsHistone Deacetylase InhibitorsHumansHydroxamic AcidsMiceMutationNuclear ProteinsPhosphorylationProtein-Tyrosine KinasesPyrazolesPyrimidinesPyrimidinonesRisk FactorsS PhaseSquamous Cell Carcinoma of Head and NeckTumor Suppressor Protein p53VorinostatConceptsOrthotopic mouse modelHNSCC cellsOral cancerMouse modelNeck squamous cell carcinomaSquamous cell carcinomaCombination of vorinostatProlongs animal survivalHNSCC cell linesClin Cancer ResClonogenic survival assaysAdvanced HNSCCAdvanced headStandard therapyCell carcinomaCure rateEffective therapyClinical investigationCell cycleP53 mutationsTumor growthVorinostatAnimal survivalAZD1775Cancer ResCharacteristics and predictors of oral cancer knowledge in a predominantly African American community
Osazuwa-Peters N, Boakye E, Hussaini A, Sujijantarat N, Ganesh R, Snider M, Thompson D, Varvares M. Characteristics and predictors of oral cancer knowledge in a predominantly African American community. PLOS ONE 2017, 12: e0177787. PMID: 28545057, PMCID: PMC5435300, DOI: 10.1371/journal.pone.0177787.Peer-Reviewed Original ResearchConceptsOral cancer knowledgeCancer knowledgeAlcohol useKnowledge scoreAfrican AmericansPrevalence of smokingHigh-risk groupCross-sectional studyEducation statusOral cancerInsurance statusSmoking ratesAfrican American populationLinear regression analysisLower educationEducational interventionMarital statusUnderstanding predictorsSmokingHigh school diplomaRegression analysisPredictorsAfrican American communityRegression modelsStatus
2014
Positive Surgical Margins in Early Stage Oral Cavity Cancer: An Analysis of 20,602 Cases
Luryi AL, Chen MM, Mehra S, Roman SA, Sosa JA, Judson BL. Positive Surgical Margins in Early Stage Oral Cavity Cancer: An Analysis of 20,602 Cases. Otolaryngology 2014, 151: 984-990. PMID: 25257901, DOI: 10.1177/0194599814551718.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnalysis of VarianceCarcinoma, Squamous CellConfidence IntervalsDatabases, FactualDisease-Free SurvivalFemaleHumansMaleMiddle AgedMouth NeoplasmsMultivariate AnalysisNeoplasm InvasivenessNeoplasm Recurrence, LocalNeoplasm StagingOral Surgical ProceduresPrognosisRetrospective StudiesRisk AssessmentSurvival AnalysisTreatment OutcomeConceptsOral cavity cancerEarly oral cavity cancerPositive surgical marginsPositive marginsMargin statusSurgical marginsCase volumeEarly-stage oral cavity cancerOral cavity squamous cell cancerDifficulty of resectionNational Cancer DatabaseStage II diseaseEarly oral cancerHospital case volumeSquamous cell cancerTreatment facility typeFloor of mouthQuality of careUseful quality measureTumor factorsClinical factorsCell cancerCancer CenterOral cancerCancer Database
2013
Awareness of HPV and its vaccine among lesbian, gay, bisexual, transgender, and queer (LGBTQ) populations.
Ong C, Winer J, Margolies L, Dai F, Patridge E, Chagpar A. Awareness of HPV and its vaccine among lesbian, gay, bisexual, transgender, and queer (LGBTQ) populations. Journal Of Clinical Oncology 2013, 31: e17597-e17597. DOI: 10.1200/jco.2013.31.15_suppl.e17597.Peer-Reviewed Original ResearchAwareness of HPVGeneral populationHPV vaccination ratesKnowledge of HPVRisk of HPVNumber of malignanciesPaucity of dataAnonymous electronic surveyHPV vaccineMedian ageOral cancerHPVVaccineCancer supplementRepresentative populationWomenElectronic surveyMalignancyCohortMenNHISLGBTQ populationsVirusPopulationTransgender people
2004
Genome wide instability scanning in chewing-tobacco associated oral cancer using inter simple sequence repeat PCR
Rai R, Kulkarni V, Saranath D. Genome wide instability scanning in chewing-tobacco associated oral cancer using inter simple sequence repeat PCR. Oral Oncology 2004, 40: 1033-1039. PMID: 15509495, DOI: 10.1016/j.oraloncology.2004.05.009.Peer-Reviewed Original ResearchConceptsOral cancerTumor tissueNormal tissuesOral cancer patientsTumor-adjacent normal tissuesOral cancer samplesAdjacent normal tissuesMultiple tumor tissuesCancer patientsNormal tissue DNATumor progressionCancer samplesGenomic instability indexCancerTissue DNAGenomic alterationsTumor heterogeneityGenomic instabilityTissueMolecular cloning, isolation and characterisation of ERK3 gene from chewing-tobacco induced oral squamous cell carcinoma
Rai R, Mahale A, Saranath D. Molecular cloning, isolation and characterisation of ERK3 gene from chewing-tobacco induced oral squamous cell carcinoma. Oral Oncology 2004, 40: 705-712. PMID: 15172640, DOI: 10.1016/j.oraloncology.2004.01.010.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceBlotting, NorthernBlotting, SouthernCarcinoma, Squamous CellCloning, MolecularDNA, ComplementaryDNA, NeoplasmGene ExpressionGene LibraryHumansMitogen-Activated Protein Kinase 6Mitogen-Activated Protein KinasesMolecular Sequence DataMouth NeoplasmsReverse Transcriptase Polymerase Chain ReactionTobacco, SmokelessConceptsOral cancer tissuesOral squamous cell carcinomaSquamous cell carcinomaPeripheral blood cellsNormal healthy individualsCancer tissuesExtracellular signal-regulated protein kinaseCell carcinomaOral cancerHealthy individualsNon-coding regionBlood cellsSerine/threonine kinaseSignal-regulated protein kinaseTobacco habitsC-Jun N-terminal kinaseFetal skeletal muscleMRNA transcript analysisNormal individualsN-terminal kinaseRegulation of mRNAPatient samplesRT-PCR analysisSkeletal muscleERK3 expression
2003
Classification and identification of genes associated with oral cancer based on gene expression profiles. A preliminary study.
Kuo W, Hasina R, Ohno-Machado L, Lingen M. Classification and identification of genes associated with oral cancer based on gene expression profiles. A preliminary study. Dental Journal 2003, 69: 23-6. PMID: 12703240.Peer-Reviewed Original ResearchConceptsGene expression profilesHuman Genome ProjectOral squamous cell carcinomaExpression profilesIdentification of genesGenome ProjectDNA microarraysMolecular networksFive-year survival rateSquamous cell carcinomaCurrent treatment strategiesGenesAggressive malignancyCell carcinomaOral cancerPreliminary studyTreatment strategiesCytologic changesEarly diagnosisSurvival rateCancerMicroarrayStatistical algorithmsCarcinomaMalignancy
2000
Food group intake and the risk of oral epithelial dysplasia in a United States population
Morse D, Pendrys D, Katz R, Holford T, Krutchkoff D, Eisenberg E, Kosis D, Kerpel S, Freedman P, Mayne S. Food group intake and the risk of oral epithelial dysplasia in a United States population. Cancer Causes & Control 2000, 11: 713-720. PMID: 11065008, DOI: 10.1023/a:1008943904085.Peer-Reviewed Original ResearchConceptsOral epithelial dysplasiaFood group intakesGroup intakesEpithelial dysplasiaOdds ratio point estimateDairy food intakeFood frequency questionnaireOral Pathology LaboratoryCase-control studyRole of dietBread/cerealsConsumption of fruitsAspects of dietUnited States populationIncident casesOral cancerOral carcinogenesisHistopathologic diagnosisLate effectsFood intakeAppointment datePotential covariatesLogistic regressionTelephone interviewsPathology laboratory
1996
Smoking and drinking in relation to oral epithelial dysplasia.
Morse D, Katz R, Pendrys D, Holford T, Krutchkoff D, Eisenberg E, Kosis D, Mayne S. Smoking and drinking in relation to oral epithelial dysplasia. Cancer Epidemiology Biomarkers & Prevention 1996, 5: 769-77. PMID: 8896887.Peer-Reviewed Original ResearchConceptsOral epithelial dysplasiaOdds ratioMouthwash useDenture statusRisk factorsEpithelial dysplasiaDrinks/weekAdjusted odds ratioImportant risk factorOral Pathology LaboratoryStandardized telephone interviewCase-control studyPotential risk factorsConditional logistic regressionLevel of smokingCurrent smokingAlcohol intakeIncident casesSmoking cessationOral cancerExcess riskHistopathological diagnosisSmokingAppointment dateLogistic regression
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