2023
TP53 Mutation-driven Stratified Mucin-producing Carcinoma Coexisting With Squamous Cell Carcinoma of the Vulva: A Case Study
Wadia R, McHenry A, Abi-Raad R, Hui P. TP53 Mutation-driven Stratified Mucin-producing Carcinoma Coexisting With Squamous Cell Carcinoma of the Vulva: A Case Study. International Journal Of Gynecological Pathology 2023, 42: 555-560. PMID: 37255422, DOI: 10.1097/pgp.0000000000000961.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaInvasive squamous cell carcinomaVulvar intraepithelial neoplasiaCell carcinomaIntraepithelial neoplasiaLichen sclerosusAssociated with high-risk human papillomavirus infectionHigh-risk human papillomavirus infectionDifferentiated vulvar intraepithelial neoplasiaPresence of lymphovascular invasionInguinal lymph node metastasisHuman papillomavirus infectionVulvar lichen sclerosusMucin-producing carcinomaLymph node metastasisIntraepithelial lesionsLymphovascular invasionTP53 mutationsNode metastasisPapillomavirus infectionNeoplastic componentsCarcinomaUnique caseTP53Sclerosus
2022
Thyroid disorders associated with lichen sclerosus: a case–control study in the All of Us Research Program
Fan R, Leasure AC, Maisha FI, Cohen JM, Little AJ. Thyroid disorders associated with lichen sclerosus: a case–control study in the All of Us Research Program. British Journal Of Dermatology 2022, 187: 797-799. PMID: 35661997, PMCID: PMC9633359, DOI: 10.1111/bjd.21702.Peer-Reviewed Original ResearchLichen Sclerosus and Sexual Dysfunction: A Systematic Review and Meta-Analysis
Pope R, Lee M, Myers A, Song J, Ghayda R, Kim J, Hong S, Lee B, Koyanagi A, Jacob L, Smith L, Shin J. Lichen Sclerosus and Sexual Dysfunction: A Systematic Review and Meta-Analysis. The Journal Of Sexual Medicine 2022, 19: 1616-1624. PMID: 36115787, DOI: 10.1016/j.jsxm.2022.07.011.Peer-Reviewed Original ResearchConceptsVulvar lichen sclerosusLichen sclerosusPrevalence of sexual dysfunctionSexual dysfunctionSexual functionVulvar lichen sclerosus et atrophicusAutoimmune dermatologic conditionsLichen sclerosus et atrophicusMeta-analysisProportion of womenExperience sexual dysfunctionKraurosis vulvaeGeneralized painSclerosusUnder-diagnosedQuality of lifeDysfunctionInclusion criteriaDermatological conditionsLS patientsSystematic reviewWomenSeeking treatmentMedical interventionsPatientsDepression and Anxiety in Patients With Lichen Sclerosus
Fan R, Leasure AC, Maisha FI, Little AJ, Cohen JM. Depression and Anxiety in Patients With Lichen Sclerosus. JAMA Dermatology 2022, 158: 953-954. PMID: 35704313, PMCID: PMC9201736, DOI: 10.1001/jamadermatol.2022.1964.Peer-Reviewed Original ResearchThe SWIFT Model for Lichen Sclerosus Among Premenarchal Girls
Wang M, Wininger M, Vash-Margita A. The SWIFT Model for Lichen Sclerosus Among Premenarchal Girls. Journal Of Lower Genital Tract Disease 2022, 26: 46-52. PMID: 34928252, DOI: 10.1097/lgt.0000000000000634.Peer-Reviewed Original ResearchConceptsPremenarchal girlsLichen sclerosusLog oddsPilot studyAccurate risk stratificationRetrospective chart reviewAdolescent gynecology clinicUseful prognostic toolMajor academic centersPremenarchal patientsChart reviewUrinary incontinenceGynecology clinicRisk stratificationUnique patientsPatient populationSingle institutionVulvovaginal complaintsTimely diagnosisPrognostic toolAcademic centersClitoral hoodClinical diagnosisPatientsDiagnosis
2021
3. SWIFT Accurately Predicts Lichen Sclerosus among Premenarchal Girls
Wang M, Wininger M, Vash-Margita A. 3. SWIFT Accurately Predicts Lichen Sclerosus among Premenarchal Girls. Journal Of Pediatric And Adolescent Gynecology 2021, 34: 240-241. DOI: 10.1016/j.jpag.2021.02.007.Peer-Reviewed Original ResearchLichen sclerosusPremenarchal girlsUrinary incontinenceVulvar complaintsPhysical examRetrospective chart reviewRisk stratification toolAdolescent gynecology clinicInstitutional review boardPremenarchal patientsChart reviewGynecology clinicClinical presentationTertiary hospitalVulvar irritationUnique patientsBackground prevalenceLS diagnosisVulvar biopsyPatient visitsInclusion criteriaEffective treatmentAverage ageDichotomous outcomesPatients
2020
Characteristics Among Premenarchal Girls With Lichen Sclerosus.
Wang M, Arlen AM, Vash-Margita A. Characteristics Among Premenarchal Girls With Lichen Sclerosus. Journal Of Lower Genital Tract Disease 2020, 25: 152-157. PMID: 33284147, DOI: 10.1097/lgt.0000000000000584.Peer-Reviewed Original ResearchConceptsLower urinary tract symptomsResolution/improvementPremenarchal girlsRetrospective chart reviewUrinary tract symptomsChronic inflammatory dermatosisPediatric urology clinicPediatric–adolescent gynecologyPaucity of dataL symptomsLS symptomsLUTS symptomsVulvar LSBowel symptomsPostmenopausal womenTract symptomsVoiding symptomsChart reviewMedian ageLichen sclerosusClinical presentationUrology clinicInflammatory dermatosesLS diagnosisPrepubertal girlsCommon Benign Chronic Vulvar Disorders.
Ringel NE, Iglesia C. Common Benign Chronic Vulvar Disorders. American Family Physician 2020, 102: 550-557. PMID: 33118795.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsTopical steroidsGenitourinary syndromeLichen sclerosusLichen planusVulvar squamous cell carcinomaTopical calcineurin inhibitorsVulvar pain disorderFirst-line treatmentItch-scratch cycleDiagnosis of exclusionInflammatory autoimmune disorderLichen simplex chronicusSquamous cell carcinomaMultimodal treatment approachIntravaginal estrogenVulvar hygieneMenopause resultsPain disordersCalcineurin inhibitorsHypoestrogenic statePersistent itchingVulvar itchingAutoimmune disordersCell carcinomaVulvar skinLichen Sclerosus in Prepubertal Girls: An Uncommon but Treatable Cause of Lower Urinary Tract Symptoms
Arlen AM, Wang M, Vash-Margita A. Lichen Sclerosus in Prepubertal Girls: An Uncommon but Treatable Cause of Lower Urinary Tract Symptoms. Urology 2020, 137: e1-e2. PMID: 31917292, DOI: 10.1016/j.urology.2019.12.029.Peer-Reviewed Original ResearchConceptsLower urinary tract symptomsUrinary tract symptomsTract symptomsPrepubertal girlsChronic inflammatory dermatosisPediatric urology providersPostmenopausal womenTreatable causeAutoimmune conditionsLichen sclerosusTreatment delayInflammatory dermatosesSkin changesAtrophic patchesPerianal regionGenetic predispositionAnogenital regionUrology providersLack of familiaritySymptomsAge distributionGirlsIncontinenceSclerosusDermatoses
2019
Adolescent Vulvar Angiokeratoma Associated with Lichen Sclerosus
Vash-Margita A, Smith Y, Rabah R, Quint EH. Adolescent Vulvar Angiokeratoma Associated with Lichen Sclerosus. Journal Of Pediatric And Adolescent Gynecology 2019, 32: 440-442. PMID: 30974213, DOI: 10.1016/j.jpag.2019.04.004.Peer-Reviewed Original ResearchConceptsLichen sclerosusVulvar angiokeratomaAsymptomatic female patientFemale adolescent populationTopical steroidsSymptomatic adolescentsFemale patientsVulvar lesionsVulvar pruritusExcised lesionsVascular lesionsPapular lesionsRare genetic diseaseSclerosusAngiokeratomaLesionsAdolescent populationPruritusPathologyAdolescentsGenetic diseasesPatientsBiopsySymptomsSteroids
2010
Lesions of the Vulva and Vagina
Chhieng D, Hui P. Lesions of the Vulva and Vagina. Current Clinical Pathology 2010, 15-34. DOI: 10.1007/978-1-60761-164-6_2.Peer-Reviewed Original ResearchSquamous cell carcinomaCell carcinomaPrimary clear cell carcinomaVulvar squamous cell carcinomaLow-risk HPV subtypesIntrauterine DES exposureHigh-risk HPVExtramammary Paget's diseaseMalignant mesenchymal tumorSquamous intraepithelial neoplasiaCommon primary malignancyClear cell carcinomaPreinvasive conditionsVulvar cancerHPV subtypesPrimary malignancyDES exposureLichen sclerosusIntraepithelial neoplasiaPaget's diseaseSquamous carcinomaWidespread metastasesAggressive angiomyxomaCondyloma acuminatumMesenchymal tumors
2005
Lichen sclerosus and eosinophilic fasciitis as manifestations of chronic graft-versus-host disease: Expanding the sclerodermoid spectrum
Schaffer JV, McNiff JM, Seropian S, Cooper DL, Bolognia JL. Lichen sclerosus and eosinophilic fasciitis as manifestations of chronic graft-versus-host disease: Expanding the sclerodermoid spectrum. Journal Of The American Academy Of Dermatology 2005, 53: 591-601. PMID: 16198778, DOI: 10.1016/j.jaad.2005.06.015.Peer-Reviewed Original ResearchConceptsEosinophilic fasciitisLichen sclerosusSclerodermoid GVHDHost diseaseBandlike lymphocytic infiltrateChronic cutaneous graftChronic cutaneous GVHDMajor clinical categoriesPresentations of GVHDClassic histologic featuresChronic graftChronic GVHDCutaneous GVHDSclerodermoid formAcute onsetCutaneous graftFollicular pluggingInitial presentationLymphocytic infiltrateCase seriesEpidermal atrophyHistologic featuresLS lesionsGVHDClinical categories
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