2024
High- versus low-gradient aortic stenosis: Is our evaluation limited by aorto-mitral angle on cardiovascular CT?
See C, Kim Y, Park J, Wang Y, Reinhardt S, Shkolnik E, Faridi K, Lombo B, Bellumkonda L, McNamara R, Sugeng L, Hur D. High- versus low-gradient aortic stenosis: Is our evaluation limited by aorto-mitral angle on cardiovascular CT? International Journal Of Cardiology 2024, 409: 132174. PMID: 38754590, DOI: 10.1016/j.ijcard.2024.132174.Peer-Reviewed Original ResearchNormal-flow low-gradientAortic valve areaTranscatheter AV replacementParadoxical low-flow low-gradientCardiovascular CTTransthoracic echocardiogramCalcium scoreAS patientsDiagnosis of severe ASLow-gradient aortic stenosisHG-AS patientsLG-AS patientsLow-flow low-gradientAorto-mitral angleAortic valve (AV) stenosisLG-ASPLFLG-ASAV replacementSevere ASConsecutive patientsAortic stenosisValve areaAS phenotypeClinical managementEchocardiogram
2023
Machine learning to predict future PSA in patients with prostate cancer managed with active surveillance.
Ayed A, Saillard C, Onofrey J, Moon I, Chang S, Feldman A, Nayan M. Machine learning to predict future PSA in patients with prostate cancer managed with active surveillance. Journal Of Clinical Oncology 2023, 41: e17098-e17098. DOI: 10.1200/jco.2023.41.16_suppl.e17098.Peer-Reviewed Original ResearchActive surveillanceAS patientsProstate cancerPSA valuesClinical featuresDiagnosis of PCaTertiary academic centerElectronic health record dataHealth record dataMean PSAPCa patientsProstate volumePSA measurementsSerial assessmentPSA assessmentPatientsAcademic centersPSARecord dataComplete dataCancerFurther validationDiagnosisSubsequent assessmentRegression models
2022
Disrupted Topological Organization of White Matter Network in Angelman Syndrome
Wei L, Du X, Yang Z, Ding M, Yang B, Wang J, Long S, Qiao Z, Jiang Y, Wang Y, Wang H. Disrupted Topological Organization of White Matter Network in Angelman Syndrome. Journal Of Magnetic Resonance Imaging 2022, 57: 1212-1221. PMID: 35856797, DOI: 10.1002/jmri.28360.Peer-Reviewed Original ResearchOne and Five-Year Mortality Risk Prediction in Patients with Moderate and Severe Aortic Stenosis
Yousef S, Amabile A, Huang H, Agarwal R, Singh S, Ram C, Milewski RK, Assi R, Zhang Y, Krane M, Geirsson A, Vallabhajosyula P. One and Five-Year Mortality Risk Prediction in Patients with Moderate and Severe Aortic Stenosis. Journal Of Clinical Medicine 2022, 11: 2949. PMID: 35629075, PMCID: PMC9146915, DOI: 10.3390/jcm11102949.Peer-Reviewed Original ResearchSevere aortic stenosisAortic stenosisRisk prediction modelPatient characteristicsDegree of ASCox proportional hazards modelModerate aortic stenosisSevere AS patientsUnadjusted overall mortalityLow ejection fractionProportional hazards modelMortality risk predictionCardiac comorbiditiesEchocardiographic evidenceOnly patientsEjection fractionOverall mortalityAS patientsHigh morbidityComplex patientsC-statisticSingle institutionIndividualized riskRisk scoreHazards model
2021
Strong association of glaucoma with atherosclerosis
Song X, Li P, Li Y, Yan X, Yuan L, Zhao C, An Y, Chang X. Strong association of glaucoma with atherosclerosis. Scientific Reports 2021, 11: 8792. PMID: 33888852, PMCID: PMC8062555, DOI: 10.1038/s41598-021-88322-4.Peer-Reviewed Original ResearchConceptsAqueous humor secretionPrimary diagnosisHumor secretionAS prevalencePrimary diagnosis of glaucomaPrimary diagnosis of hypertensionAngle-closure glaucomaHigh intraocular pressureAssociation of glaucomaDiagnosis of glaucomaEffects of methazolamideLow-density lipoprotein (LDLDiagnosis of hypertensionReduce low-density lipoprotein (LDLGlaucoma prevalenceIntraocular pressureLipoprotein (LDLGlaucoma pathogenesisOphthalmic recordsTreat glaucomaAS patientsGlaucomaOphthalmic diseasesMouse modelIncidence of A
2019
Potassium channel dysfunction in human neuronal models of Angelman syndrome
Sun A, Yuan Q, Fukuda M, Yu W, Yan H, Lim G, Nai M, D'Agostino G, Tran H, Itahana Y, Wang D, Lokman H, Itahana K, Lim S, Tang J, Chang Y, Zhang M, Cook S, Rackham O, Lim C, Tan E, Ng H, Lim K, Jiang Y, Je H. Potassium channel dysfunction in human neuronal models of Angelman syndrome. Science 2019, 366: 1486-1492. PMID: 31857479, PMCID: PMC7735558, DOI: 10.1126/science.aav5386.Peer-Reviewed Original ResearchConceptsAngelman syndromePotassium channel dysfunctionAS mouse modelUbiquitin protein ligase E3A (UBE3A) geneHuman neuronal modelNeuronal hyperexcitabilityNetwork hyperactivityAS patientsSeizure susceptibilitySynaptic dysfunctionModel miceIntrinsic excitabilityNeuronal excitabilityMouse modelBig potassium channelsHuman neuronsChannel dysfunctionEpilepsy susceptibilityBK channelopathyMouse neuronsPotassium channelsIndividual neuronsBrain organoidsNeuronsDysfunction
2018
Galectin‐3 exacerbates ox‐LDL‐mediated endothelial injury by inducing inflammation via integrin β1‐RhoA‐JNK signaling activation
Chen X, Lin J, Hu T, Ren Z, Li L, Hameed I, Zhang X, Men C, Guo Y, Xu D, Zhan Y. Galectin‐3 exacerbates ox‐LDL‐mediated endothelial injury by inducing inflammation via integrin β1‐RhoA‐JNK signaling activation. Journal Of Cellular Physiology 2018, 234: 10990-11000. PMID: 30536538, PMCID: PMC6590151, DOI: 10.1002/jcp.27910.Peer-Reviewed Original ResearchMeSH KeywordsAtherosclerosisCell Adhesion MoleculesCell SurvivalEndothelium, Vascularfas ReceptorGalectin 3Gene Expression RegulationHuman Umbilical Vein Endothelial CellsHumansInflammationIntegrin beta1JNK Mitogen-Activated Protein KinasesLipoproteins, LDLMAP Kinase Signaling SystemrhoA GTP-Binding ProteinConceptsHuman umbilical vascular endothelial cellsEndothelial injuryGal-3P-JNKInflammatory factorsGTP-RhoAGalectin-3Plasma galectin-3Systemic inflammatory disorderEndothelial cell injuryPathogenesis of atherosclerosisLow-density lipoproteinNF-κB activationVascular endothelial cellsEndothelial dysfunctionP-IKKβAS patientsInflammatory disordersP-p65P-IKKαCardiovascular diseaseOx-LDLCell injuryCCK8 assayControl group
2015
Parental origin impairment of synaptic functions and behaviors in cytoplasmic FMRP interacting protein 1 (Cyfip1) deficient mice
Chung L, Wang X, Zhu L, Towers AJ, Cao X, Kim IH, Jiang YH. Parental origin impairment of synaptic functions and behaviors in cytoplasmic FMRP interacting protein 1 (Cyfip1) deficient mice. Brain Research 2015, 1629: 340-350. PMID: 26474913, PMCID: PMC4744651, DOI: 10.1016/j.brainres.2015.10.015.Peer-Reviewed Original ResearchConceptsPrader-Willi syndromeClinical presentationClass ISynaptic transmissionExpression of CYFIP1Impaired synaptic transmissionRole of CYFIP1Breakpoint 2Severe clinical presentationLong-term depressionCued fear conditioningPaired-pulse facilitationZero-maze testHuman neuropsychiatric disordersClass II deletionsBreakpoints 1Neurological presentationAS patientsHippocampal CA1Deficient miceTerm depressionMaternal deficiencyPatientsHaploinsufficiency of Cyfip1Synaptic function
2010
Altered Ultrasonic Vocalization and Impaired Learning and Memory in Angelman Syndrome Mouse Model with a Large Maternal Deletion from Ube3a to Gabrb3
Jiang YH, Pan Y, Zhu L, Landa L, Yoo J, Spencer C, Lorenzo I, Brilliant M, Noebels J, Beaudet AL. Altered Ultrasonic Vocalization and Impaired Learning and Memory in Angelman Syndrome Mouse Model with a Large Maternal Deletion from Ube3a to Gabrb3. PLOS ONE 2010, 5: e12278. PMID: 20808828, PMCID: PMC2924885, DOI: 10.1371/journal.pone.0012278.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphatasesAngelman SyndromeAnimalsCerebral CortexChromosome DeletionDarknessDisease Models, AnimalExploratory BehaviorFemaleGene Expression RegulationHomozygoteMaleMembrane Transport ProteinsMemoryMiceMothersMotor ActivityReceptors, GABA-ASeizuresUbiquitin-Protein LigasesUltrasonicsVocalization, AnimalConceptsLarge maternal deletionsDeletion miceMutant miceMouse modelAngelman syndrome mouse modelAngelman syndromeSpontaneous seizure activityMaternal deletionAS mouse modelGABRB3 geneWild-type littermatesSyndrome mouse modelE6-AP ubiquitinLight-dark boxDeletion mutant miceUBE3A mutationsUniparental disomyElectroencephalography (EEG) abnormalitiesAS patientsAbnormal EEGSeizure activityMotor functionPerinatal periodBalance disordersPaternal uniparental disomy
2009
The Management of Spinal Injuries in Patients With Ankylosing Spondylitis or Diffuse Idiopathic Skeletal Hyperostosis
Whang PG, Goldberg G, Lawrence JP, Hong J, Harrop JS, Anderson DG, Albert TJ, Vaccaro AR. The Management of Spinal Injuries in Patients With Ankylosing Spondylitis or Diffuse Idiopathic Skeletal Hyperostosis. Clinical Spine Surgery A Spine Publication 2009, 22: 77-85. PMID: 19342927, DOI: 10.1097/bsd.0b013e3181679bcb.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overComorbidityDisability EvaluationFemaleHumansHyperostosis, Diffuse Idiopathic SkeletalMaleMiddle AgedMortalityNeurosurgical ProceduresOutcome Assessment, Health CarePostoperative ComplicationsRadiographyRetrospective StudiesSpinal Cord CompressionSpinal FracturesSpinal InjuriesSpineSpondylitis, AnkylosingTreatment OutcomeConceptsDiffuse idiopathic skeletal hyperostosisIdiopathic skeletal hyperostosisSpinal injuryDISH patientsNeurologic deficitsClinical outcomesAS patientsSkeletal hyperostosisAmerican Spinal Injury Association Impairment ScaleHalo-vest orthosisOverall complication rateHalo-vest immobilizationAppropriate imaging studiesSpinal cord injurySubaxial cervical spineOdom's criteriaNonoperative treatmentComplication rateNeurologic injuryNeurologic statusASIA ARetrospective reviewOperative managementCord injurySingle institution
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