2020
p62-dependent autophagy in airway smooth muscle cells regulates metabolic reprogramming and promotes airway remodeling
Yu H, Cheng Y, Zhang G, Wang X, Gu W, Guo X. p62-dependent autophagy in airway smooth muscle cells regulates metabolic reprogramming and promotes airway remodeling. Life Sciences 2020, 266: 118884. PMID: 33310038, DOI: 10.1016/j.lfs.2020.118884.Peer-Reviewed Original ResearchConceptsKnockdown of p62Mechanism of p62Bronchial smooth muscle cellsP62-dependent autophagyIncreased p62 expressionP62 expressionAirway remodelingGlucose consumptionAutophagy fluxAutophagic fluxCCK8 assayP62 overexpressionTranswell methodP62Glycolytic genesGlycolytic proteinsLactate productionMetabolic reprogrammingMigration in vitroHuman bronchial smooth muscle cellsBSMC proliferationCell migrationSmooth muscle cellsAirway remodeling processPromote airway remodeling
2018
Galectin‐3 exacerbates ox‐LDL‐mediated endothelial injury by inducing inflammation via integrin β1‐RhoA‐JNK signaling activation
Chen X, Lin J, Hu T, Ren Z, Li L, Hameed I, Zhang X, Men C, Guo Y, Xu D, Zhan Y. Galectin‐3 exacerbates ox‐LDL‐mediated endothelial injury by inducing inflammation via integrin β1‐RhoA‐JNK signaling activation. Journal Of Cellular Physiology 2018, 234: 10990-11000. PMID: 30536538, PMCID: PMC6590151, DOI: 10.1002/jcp.27910.Peer-Reviewed Original ResearchMeSH KeywordsAtherosclerosisCell Adhesion MoleculesCell SurvivalEndothelium, Vascularfas ReceptorGalectin 3Gene Expression RegulationHuman Umbilical Vein Endothelial CellsHumansInflammationIntegrin beta1JNK Mitogen-Activated Protein KinasesLipoproteins, LDLMAP Kinase Signaling SystemrhoA GTP-Binding ProteinConceptsHuman umbilical vascular endothelial cellsEndothelial injuryGal-3P-JNKInflammatory factorsGTP-RhoAGalectin-3Plasma galectin-3Systemic inflammatory disorderEndothelial cell injuryPathogenesis of atherosclerosisLow-density lipoproteinNF-κB activationVascular endothelial cellsEndothelial dysfunctionP-IKKβAS patientsInflammatory disordersP-p65P-IKKαCardiovascular diseaseOx-LDLCell injuryCCK8 assayControl group
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