2023
Genetics of Diffuse Idiopathic Skeletal Hyperostosis and Ossification of the Spinal Ligaments
Kato H, Braddock D, Ito N. Genetics of Diffuse Idiopathic Skeletal Hyperostosis and Ossification of the Spinal Ligaments. Current Osteoporosis Reports 2023, 21: 552-566. PMID: 37530996, PMCID: PMC10543536, DOI: 10.1007/s11914-023-00814-6.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDiffuse idiopathic skeletal hyperostosisAutosomal recessive hypophosphatemic rickets type 2Idiopathic skeletal hyperostosisSkeletal hyperostosisOPLL patientsGenetic factorsPathogenic variantsFibroblast growth factor 23Growth factor 23Posterior longitudinal ligamentSpinal ligament ossificationRecent FindingsRecent studiesStrong genetic factorImportant new biomarkerDisease courseFactor 23Longitudinal ligamentClinical evaluationPlasma biomarkersClinical trialsLigament ossificationPlasma PPiCalcification disordersPatientsEctopic calcification
2020
Identification of ENPP1 Haploinsufficiency in Patients With Diffuse Idiopathic Skeletal Hyperostosis and Early‐Onset Osteoporosis
Kato H, Ansh AJ, Lester ER, Kinoshita Y, Hidaka N, Hoshino Y, Koga M, Taniguchi Y, Uchida T, Yamaguchi H, Niida Y, Nakazato M, Nangaku M, Makita N, Takamura T, Saito T, Braddock DT, Ito N. Identification of ENPP1 Haploinsufficiency in Patients With Diffuse Idiopathic Skeletal Hyperostosis and Early‐Onset Osteoporosis. Journal Of Bone And Mineral Research 2020, 37: 1125-1135. PMID: 35340077, PMCID: PMC9177665, DOI: 10.1002/jbmr.4550.Peer-Reviewed Original ResearchConceptsAutosomal recessive hypophosphatemic rickets type 2Diffuse idiopathic skeletal hyperostosisEarly-onset osteoporosisENPP1 variantsHypophosphatemic ricketsENPP1 mutationsFibroblast growth factor 23Case 1Growth factor 23Serum phosphate levelsIdiopathic skeletal hyperostosisPosterior longitudinal ligamentCase 3Spinal ligament ossificationFactor 23Skeletal hyperostosisArterial calcificationLongitudinal ligamentPresumptive diagnosisLigament ossificationSevere ossificationMutational statusType 2Pathogenic lossGenetic testing
2011
An Unusual cause of Acute Hypercapneic Respiratory Failure
Wang J, Chichra A, Koenig S. An Unusual cause of Acute Hypercapneic Respiratory Failure. Therapeutic Advances In Pulmonary And Critical Care Medicine 2011, 5: ccrpm.s7687. PMID: 22174594, PMCID: PMC3236007, DOI: 10.4137/ccrpm.s7687.Peer-Reviewed Case Reports and Technical NotesHypercapneic respiratory failureRespiratory failureAcute hypercapneic respiratory failureDiffuse idiopathic skeletal hyperostosisUpper airway obstructionIdiopathic skeletal hyperostosisIntrinsic pulmonary diseaseProgressive dyspneaAirway obstructionExtensive workupNeurologic causesPulmonary diseaseRare causeUnusual causeObvious etiologySkeletal hyperostosisCase reportDiagnostic imagingCauseFailureDyspneaChronicEtiologyHyperostosisObstruction
2009
The Management of Spinal Injuries in Patients With Ankylosing Spondylitis or Diffuse Idiopathic Skeletal Hyperostosis
Whang PG, Goldberg G, Lawrence JP, Hong J, Harrop JS, Anderson DG, Albert TJ, Vaccaro AR. The Management of Spinal Injuries in Patients With Ankylosing Spondylitis or Diffuse Idiopathic Skeletal Hyperostosis. Clinical Spine Surgery A Spine Publication 2009, 22: 77-85. PMID: 19342927, DOI: 10.1097/bsd.0b013e3181679bcb.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overComorbidityDisability EvaluationFemaleHumansHyperostosis, Diffuse Idiopathic SkeletalMaleMiddle AgedMortalityNeurosurgical ProceduresOutcome Assessment, Health CarePostoperative ComplicationsRadiographyRetrospective StudiesSpinal Cord CompressionSpinal FracturesSpinal InjuriesSpineSpondylitis, AnkylosingTreatment OutcomeConceptsDiffuse idiopathic skeletal hyperostosisIdiopathic skeletal hyperostosisSpinal injuryDISH patientsNeurologic deficitsClinical outcomesAS patientsSkeletal hyperostosisAmerican Spinal Injury Association Impairment ScaleHalo-vest orthosisOverall complication rateHalo-vest immobilizationAppropriate imaging studiesSpinal cord injurySubaxial cervical spineOdom's criteriaNonoperative treatmentComplication rateNeurologic injuryNeurologic statusASIA ARetrospective reviewOperative managementCord injurySingle institution
2007
P64. The Initial Assessment and Early Management of Spine Fractures in Patients with Ankylosing Spondylitis or Diffuse Idiopathic Skeletal Hyperostosis: A Comparison of Treatment Methods
Whang P, Goldberg G, Brown Z, Sanfilippo J, Anderson G, Albert T, Hilibrand A, Vaccaro A. P64. The Initial Assessment and Early Management of Spine Fractures in Patients with Ankylosing Spondylitis or Diffuse Idiopathic Skeletal Hyperostosis: A Comparison of Treatment Methods. The Spine Journal 2007, 7: 112s. DOI: 10.1016/j.spinee.2007.07.270.Peer-Reviewed Original ResearchDiffuse idiopathic skeletal hyperostosisIdiopathic skeletal hyperostosisSpine fracturesSkeletal hyperostosisEarly managementInitial assessmentTreatment methodsSpondylitisPatientsHyperostosis
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