2022
Sexual dimorphism in a neuronal mechanism of spinal hyperexcitability across rodent and human models of pathological pain
Dedek A, Xu J, Lorenzo LÉ, Godin AG, Kandegedara CM, Glavina G, Landrigan JA, Lombroso PJ, De Koninck Y, Tsai EC, Hildebrand ME. Sexual dimorphism in a neuronal mechanism of spinal hyperexcitability across rodent and human models of pathological pain. Brain 2022, 145: 1124-1138. PMID: 35323848, PMCID: PMC9050559, DOI: 10.1093/brain/awab408.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorSuperficial dorsal horn neuronsDorsal horn neuronsFemale ratsNeurotrophic factorNeuronal mechanismsCentral neuronal mechanismsSpinal nociceptive circuitsSpinal pain processingSuperficial dorsal hornChronic pain syndromeLamina I neuronsPreclinical pain modelsHuman organ donorsSynaptic NMDAR responsesNMDAR potentiationSpinal hyperexcitabilityInflammatory painNociceptive circuitsPain syndromeTactile allodyniaDorsal hornPain modelPathological painLaminae I
2020
Dendritic Spine Dynamics after Peripheral Nerve Injury: An Intravital Structural Study
Benson CA, Fenrich KK, Olson KL, Patwa S, Bangalore L, Waxman SG, Tan AM. Dendritic Spine Dynamics after Peripheral Nerve Injury: An Intravital Structural Study. Journal Of Neuroscience 2020, 40: 4297-4308. PMID: 32371602, PMCID: PMC7252482, DOI: 10.1523/jneurosci.2858-19.2020.Peer-Reviewed Original ResearchConceptsDendritic spine dynamicsInjury-induced painPeripheral nerve injuryNeuropathic painDorsal hornSpine dynamicsNerve injuryPeripheral nerve injury-induced painNerve injury-induced painSuperficial dorsal horn neuronsSpinal cord dorsal hornDorsal horn neuronsSuperficial dorsal hornMechanisms of painDendritic spine dysgenesisContext of injuryPostmortem tissue analysisSame dendritic branchRepeat imagingMale miceMedical conditionsEffective treatmentPainSpine dysgenesisDendritic spines
1999
Development of glomerular synaptic complexes and immunohistochemical differentiation in the superficial dorsal horn of the embryonic primate spinal cord
Knyihar-Csillik E, Rakic P, Csillik B. Development of glomerular synaptic complexes and immunohistochemical differentiation in the superficial dorsal horn of the embryonic primate spinal cord. Brain Structure And Function 1999, 199: 125-148. PMID: 9930620, DOI: 10.1007/s004290050215.Peer-Reviewed Original ResearchConceptsSuperficial dorsal hornGlomerular synaptic complexesPrimate spinal cordDorsal hornDorsal root afferentsDorsal root axonsSubstance PSpinal cordSynaptic contactsPrimate dorsal hornSubstantia gelatinosa cellsPrimary afferent terminalsCB-immunoreactive cellsMacaque spinal cordFinal target cellPost-synaptic specializationsCharacteristic cytological featuresGrowth conesPre-embedding immunohistochemistryLaminae IAfferent terminalsImmunohistochemical differentiationGlomerular synapsesAxon terminalsCalcitonin gene
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply